Abstract: In various examples, a virtually animated and interactive agent may be rendered for visual and audible communication with one or more users with an application. For example, a conversational artificial intelligence (AI) assistant may be rendered and displayed for visual communication in addition to audible communication with end-users. As such, the AI assistant may leverage the visual domain—in addition to the audible domain—to more clearly communicate with users, including interacting with a virtual environment in which the AI assistant is rendered. Similarly, the AI assistant may leverage audio, video, and/or text inputs from a user to determine a request, mood, gesture, and/or posture of a user for more accurately responding to and interacting with the user.

Abstract: In various examples, a virtually animated and interactive agent may be rendered for visual and audible communication with one or more users with an application. For example, a conversational artificial intelligence (AI) assistant may be rendered and displayed for visual communication in addition to audible communication with end-users. As such, the AI assistant may leverage the visual domain—in addition to the audible domain—to more clearly communicate with users, including interacting with a virtual environment in which the AI assistant is rendered. Similarly, the AI assistant may leverage audio, video, and/or text inputs from a user to determine a request, mood, gesture, and/or posture of a user for more accurately responding to and interacting with the user.

Abstract: Provided are substituted 8-methylquinazolin-4(3H)-one compounds useful as PARP inhibitors for the treatment of cancer and asthma, as well as pharmaceutical compositions comprising them and methods for their synthesis.

Abstract: This invention provides systems and methods for determining and capturing desired perspective views of objects of interest (OOIs) including locating each OOI and determining an orientation of each OOI, or simultaneously detecting and tracking multiple objects of interest while assigning a position in space for each OOI and further securely transmitting the captured information to a remote location.

Abstract: Systems and techniques are described related to providing dynamic, configurable, runtime model alignment—in the form of guardrails, in embodiments—for language models (such as LLMs) using a formal modeling language. In at least one embodiment, a dialog flow is determined based on a user input and executed using a language model to generate an output. The dialog flow is specified in a formal modeling programming language and controls output of the language model.

Abstract: The present invention concerns phthalazinone-based compounds of that inhibit the PARP-1 protein, the compounds having Formula (I):

Abstract: An improved catheter apparatus is disclosed for use with a hemostasis valve having a compression seal for temporarily creating a reduced inner diameter within a valve lumen of the valve. In at least one embodiment, the apparatus provides an elongate catheter having at least one protrusion radially extending outwardly from an outer surface of the catheter, the at least one protrusion having an outer diameter that is less than a neutral inner diameter of the valve lumen but greater than the reduced inner diameter of the valve lumen. During use of the apparatus, with the catheter positioned a distance within the valve lumen and the compression seal subsequently creating the reduced inner diameter within the valve lumen, the at least one protrusion contacts the compression seal and prevents the catheter from sliding out of the valve.

Abstract: Provided are substituted 8-methylquinazolin-4(3H)-one compounds useful as PARP inhibitors for the treatment of cancer and asthma, as well as pharmaceutical compositions comprising them and methods for their synthesis.

Abstract: This invention provides, in some aspects, for devices and methods for protecting a sensitive structure against large explosive warhead containing weaponry, whereby a protective apparatus is positioned to be facing an anticipated impact direction at a spacing from said sensitive structure, wherein said apparatus detonates the weapon while absorbing the impact of the explosive warhead containing weaponry.

Abstract: This invention provides mechanical valve device and ring systems for cardiac valve replacement, wherein the mechanical valve devices comprises two or more leaflets, each leaflet comprising at least a first material which reduces electrostatic forces between blood and device components, reduces adhesion between blood and device components or a combination thereof; and optionally further comprises at least a first magnet incorporated within at least one of the leaflets; and a valve constraining ring, comprising at least a first material which reduces electrostatic forces between blood and device components, reduces adhesion between blood and device components or a combination thereof; and internally located attachment regions for the leaflets; and optionally at least a second magnet of matched polarity to said first magnet, incorporated within the valve constraining ring at regions proximal to said first magnet within said leaflet such that repulsive forces are present when said first magnet and said second mag

Abstract: Aspects of the disclosures allow for a touchless or hands-free closing, opening, and holding (in a closed state) of a door system, including, but not limited to doors for stalls in public restrooms. Embodiments of the door opening system may include touchless mechanisms and methods that utilize various mechanical, electromechanical, and/or electronic systems and components. Aspects of the disclosures also allow for occupancy indication for a door system, including, but not limited to doors for stalls in public restrooms. Embodiments of the occupancy indication system may include an occupancy indicator that may be pushed away from a door panel to indicate whether the bathroom stall is occupied or not occupied.

Abstract: The present invention concerns novel compounds, pharmaceutical compositions, and methods for promoting nerve regeneration, particularly including sympathetic nerve regeneration in the heart following a myocardial infarction and damage to the central nervous system, such as after a cerebrovascular accident, through inhibitory extracellular matrix that includes chondroitin sulfate roteoglycans (CSPG).

Abstract: A method for fusion of radar and visual information, the method comprises: obtaining visual information and radar information about a three dimensional (3D) space located within a field of view of a camera that acquired the visual information and within a field of view of a radar that acquired the radar information; finding, based on the visual information, estimated visual-detection-based (VDB) objects and estimated VDB locations of the estimated VDB objects within the 3D space; wherein the estimated VDB locations exhibit a distance ambiguity; determining hybrid-detection-based (HDB) objects and HDB locations of the HDB objects, based on (i) the radar information, (ii) the estimated VDB objects, and (iii) the estimated VDB locations of the VDB objects.

Abstract: Provided herein are novel compounds, compositions, that can used as clickable, photo-affinity labeling (PAL) probes methods for use in screening NAD+ binding proteins.

Abstract: A portable air processing system that takes air from the ambient or other component, heats the air to a sufficient temperature so as to deactivate at least one type of pathogen or allergen, then cools the air to a comfortable breathing temperature, and then feeds this processed air under positive pressure to a controlled environment or mask covering the nose and mouth of a wearer, thus enabling one to breath cleaner air from a controlled source while mobile or stationary.

Abstract: A computer-implemented method comprising: receiving, by a computing device, prescription information for an individual identifying a medication and a condition; identifying, by the computing device, job roles impacted by the condition; identifying, by the computing device, job roles impacted by side effects of the medication; determining, by the computing device, that a working capacity of the individual is diminished by the condition or the side effects of the medication based on job roles of the individual; generating, by the computing device, mitigation instructions in response to the determining; and executing, by the computing device, the mitigation instructions.

Abstract: Mutant mono ADP-ribose-polymerases (mono-PARP) proteins and small molecule compound substrates specific for the mutant mono-PARP proteins as well as methods of using these compositions to identify protein targets of the mono-PARPs and to screen for antagonists of the mono-PARPs are described.

Abstract: Systems and method are provided for securing physical-location transfers that include receiving object information associated with a particular physical location; receiving user information associated with a user that owns the physical location; generating a protected object associated with the physical location, wherein the protected object is generated based on the object information and the user information; generating a user key associated with the physical location, wherein generating the user key is based on the object information and the user information; storing the user key and a physical-location identifier associated with the physical location in a database; receiving a transfer request associated with the physical location, the transfer request including the user key; transmitting an authorization request for the transfer associated with the physical location; and receiving one of an authorization for the transfer associated with the physical location and a cancellation for the transfer associated

Abstract: The present invention provides compounds useful as mitochondrial permeability transition pore (mtPTP) inhibitors, the compounds being of Formula (I), or a pharmaceutically acceptable salt thereof wherein R1 is selected from the group of H, halogen, and C1-C3 alkyl; and R2 is selected from the group of H, CF3, and halogen; with the proviso that at least one of R1 and R2 is halogen or CF3.