Abstract: A nuclear reactor must be designed and constructed to withstand seismic events. A modular integrated reactor support structure includes seismic isolators that rely on viscous dampers and elastic support assemblies to provide three-dimensional seismic isolation to the reactor head, reactor vessel and reactor internal components. The gravitational load of the reactor head, reactor vessel, and reactor internals is supported through the reactor head, which transfers the load to a plurality of seismic isolators, which in turn, transfer the load to the basemat of the reactor building. A plurality of reactor support assembly blocks couple the reactor head to the seismic isolators while permitting thermal expansion and contraction of the reactor head while limiting rotational motion.

Abstract: This invention provides, in some embodiments, an impact- and blast-resistance improved aircraft pilot chair, which is able to provide improved protection to a pilot, from exposure to significant G forces and/or exposure to projectiles including projectiles penetrating the aircraft and/or effects of pilot chair ejection and/or effects of aircraft crash

Abstract: Provided herein are novel compounds, compositions, that can used as clickable, photo-affinity labeling (PAL) probes methods for use in screening NAD+ binding proteins.

Abstract: Provided are substituted 8-methylquinazolin-4(3H)-one compounds useful as PARP inhibitors for the treatment of cancer and asthma, as well as pharmaceutical compositions comprising them and methods for their synthesis.

Abstract: The present invention provides compounds useful as mitochondrial permeability transition pore (mtPTP) inhibitors, the compounds being of Formula (I), or a pharmaceutically acceptable salt thereof wherein R1 is selected from the group of H, halogen, and C1-C3 alkyl; and R2 is selected from the group of H, CF3, and halogen; with the proviso that at least one of R1 and R2 is halogen or CF3.

Abstract: Provided are substituted 8-methylquinazolin-4(3H)-one compounds useful as PARP inhibitors for the treatment of cancer and asthma, as well as pharmaceutical compositions comprising them and methods for their synthesis.

Abstract: This invention provides systems and methods for determining and capturing desired perspective views of objects of interest (OOIs) including locating each OOI and determining an orientation of each OOI, or simultaneously detecting and tracking multiple objects of interest while assigning a position in space for each OOI and further securely transmitting the captured information to a remote location.

Abstract: The present invention concerns phthalazinone-based compounds of that inhibit the PARP-1 protein, the compounds having Formula (I):

Abstract: Provided are substituted 8-methylquinazolin-4(3H)-one compounds useful as PARP inhibitors for the treatment of cancer and asthma, as well as pharmaceutical compositions comprising them and methods for their synthesis.

Abstract: This invention provides, in some aspects, for devices and methods for protecting a sensitive structure against large explosive warhead containing weaponry, whereby a protective apparatus is positioned to be facing an anticipated impact direction at a spacing from said sensitive structure, wherein said apparatus detonates the weapon while absorbing the impact of the explosive warhead containing weaponry.

Abstract: This invention provides mechanical valve device and ring systems for cardiac valve replacement, wherein the mechanical valve devices comprises two or more leaflets, each leaflet comprising at least a first material which reduces electrostatic forces between blood and device components, reduces adhesion between blood and device components or a combination thereof; and optionally further comprises at least a first magnet incorporated within at least one of the leaflets; and a valve constraining ring, comprising at least a first material which reduces electrostatic forces between blood and device components, reduces adhesion between blood and device components or a combination thereof; and internally located attachment regions for the leaflets; and optionally at least a second magnet of matched polarity to said first magnet, incorporated within the valve constraining ring at regions proximal to said first magnet within said leaflet such that repulsive forces are present when said first magnet and said second mag

Abstract: Aspects of the disclosures allow for a touchless or hands-free closing, opening, and holding (in a closed state) of a door system, including, but not limited to doors for stalls in public restrooms. Embodiments of the door opening system may include touchless mechanisms and methods that utilize various mechanical, electromechanical, and/or electronic systems and components. Aspects of the disclosures also allow for occupancy indication for a door system, including, but not limited to doors for stalls in public restrooms. Embodiments of the occupancy indication system may include an occupancy indicator that may be pushed away from a door panel to indicate whether the bathroom stall is occupied or not occupied.

Abstract: The present invention concerns novel compounds, pharmaceutical compositions, and methods for promoting nerve regeneration, particularly including sympathetic nerve regeneration in the heart following a myocardial infarction and damage to the central nervous system, such as after a cerebrovascular accident, through inhibitory extracellular matrix that includes chondroitin sulfate roteoglycans (CSPG).

Abstract: A method for fusion of radar and visual information, the method comprises: obtaining visual information and radar information about a three dimensional (3D) space located within a field of view of a camera that acquired the visual information and within a field of view of a radar that acquired the radar information; finding, based on the visual information, estimated visual-detection-based (VDB) objects and estimated VDB locations of the estimated VDB objects within the 3D space; wherein the estimated VDB locations exhibit a distance ambiguity; determining hybrid-detection-based (HDB) objects and HDB locations of the HDB objects, based on (i) the radar information, (ii) the estimated VDB objects, and (iii) the estimated VDB locations of the VDB objects.

Abstract: Provided herein are novel compounds, compositions, that can used as clickable, photo-affinity labeling (PAL) probes methods for use in screening NAD+ binding proteins.

Abstract: Mutant mono ADP-ribose-polymerases (mono-PARP) proteins and small molecule compound substrates specific for the mutant mono-PARP proteins as well as methods of using these compositions to identify protein targets of the mono-PARPs and to screen for antagonists of the mono-PARPs are described.

Abstract: The present invention provides compounds useful as mitochondrial permeability transition pore (mtPTP) inhibitors, the compounds being of Formula (I), or a pharmaceutically acceptable salt thereof wherein R1 is selected from the group of H, halogen, and C1-C3 alkyl; and R2 is selected from the group of H, CF3, and halogen; with the proviso that at least one of R1 and R2 is halogen or CF3.

Abstract: A tamper-resistant nozzle assembly for preventing the unwanted or unintentional dispensing of a material from a container. The nozzle assembly may comprise a base adapted to fit on top of a container holding the material, a mechanism located within the base and configured to provide tamper-resistant properties for the nozzle assembly, a nozzle connected to the base and having a pair of diametrically opposed tabs extending downwardly therefrom into the base, the tabs being capable of travelling radially inward when squeezed by a user, whereby, in a locked state, the mechanism limits the travel of the tabs such that (1) the nozzle cannot rotate relative to the base, and (2) the nozzle cannot be depressed to release the material from the container. When a user squeezes the tabs, the mechanism is in an unlocked state and permits the rotation of the nozzle relative to the base, to thereby enable the nozzle to be depressed relative to the base to allow it to dispense the material from the container.

Abstract: A tamper-resistant nozzle assembly for preventing the unwanted or unintentional dispensing of a material from a container. The nozzle assembly may comprise a base adapted to fit on top of a container holding the material, a mechanism located within the base and configured to provide tamper-resistant properties for the nozzle assembly, a nozzle connected to the base and having a pair of diametrically opposed tabs extending downwardly therefrom into the base, the tabs being capable of travelling radially inward when squeezed by a user, whereby, in a locked state, the mechanism limits the travel of the tabs such that (1) the nozzle cannot rotate relative to the base, and (2) the nozzle cannot be depressed to release the material from the container. When a user squeezes the tabs, the mechanism is in an unlocked state and permits the rotation of the nozzle relative to the base, to thereby enable the nozzle to be depressed relative to the base to allow it to dispense the material from the container.