Patents by Inventor Michael Colin Lawrence

Michael Colin Lawrence has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • INSULIN ANALOGS
    Publication number: 20220340636
    Abstract: The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.
    Type: Application
    Filed: January 4, 2022
    Publication date: October 27, 2022
    Inventors: John Gerbrandt Tasman MENTING, Brian SMITH, Danny Hung-Chieh CHOU, Helena SAFAVI-HEMAMI, Michael Colin LAWRENCE, Baldomero M. OLIVERA
  • Insulin analogs
    Patent number: 11248034
    Abstract: The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.
    Type: Grant
    Filed: July 21, 2017
    Date of Patent: February 15, 2022
    Assignees: University of Utah Research Foundation, The Walter and Eliza Hall Institute of Medical Research
    Inventors: John Gerbrandt Tasman Menting, Brian Smith, Danny Hung-Chieh Chou, Helena Safavi-Hemami, Michael Colin Lawrence, Baldomero M. Olivera
  • INSULIN ANALOGS
    Publication number: 20190241640
    Abstract: The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.
    Type: Application
    Filed: July 21, 2017
    Publication date: August 8, 2019
    Inventors: John Gerbrandt Tasman MENTING, Brian SMITH, Danny Hung-Chieh CHOU, Helena SAFAVI-HEMAMI, Michael Colin LAWRENCE, Olivera M. BALDOMERO
  • STRUCTURE OF INSULIN IN COMPLEX WITH N- AND C-TERMINAL REGIONS OF THE INSULIN RECEPTOR ALPHA-CHAIN
    Publication number: 20150198619
    Abstract: The present invention relates to the crystal structure of the insulin receptor ectodomain in complex with human insulin and to methods of using the crystal and related structural information to identify, design and screen for compounds that interact with or modulate the insulin receptor and insulin receptor signalling.
    Type: Application
    Filed: September 18, 2013
    Publication date: July 16, 2015
    Inventors: Michael Colin Lawrence, John Gerbrandt Tasman Menting, Brian John Smith
  • Structure of the C-terminal region of the insulin receptor ?-chain and of the insulin-like growth factor receptor ?-chain
    Patent number: 8666718
    Abstract: The present invention relates generally to structural studies of the insulin binding site of the insulin receptor (IR) and the insulin-like growth factor 1 receptor (IGF-1R). More particularly, the present invention relates to the crystal structure of the low affinity insulin binding site of the IR ectodomain comprising the C-terminal region of the IR ?-chain, as well as the corresponding region of IGF-1R, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the function of IR and/or IGF-1R.
    Type: Grant
    Filed: March 9, 2010
    Date of Patent: March 4, 2014
    Assignee: The Walter and Eliza Hall Institute of Medical Research
    Inventors: Michael Colin Lawrence, Brian John Smith, John Gerbrandt Tasman Menting, Colin Wesley Ward
  • Structure of the insulin receptor ectodomain
    Patent number: 8301398
    Abstract: The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the closely-related insulin-like growth factor receptors or variants thereof.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: October 30, 2012
    Assignee: Walter and Eliza Hall Institute of Medical Research
    Inventors: Thomas P. J. Garrett, Timothy Edward Adams, George Lovrecz, Neil Moreton McKern, Michael Colin Lawrence, Lindsay Gale Sparrow, Colin Wesley Ward, Meizhen Lou, Victor Strelstov
  • STRUCTURE OF THE C-TERMINAL REGION OF THE INSULIN RECEPTOR a-CHAIN AND OF THE INSULIN-LIKE GROWTH FACTOR RECEPTOR a-CHAIN
    Publication number: 20120122771
    Abstract: The present invention relates generally to structural studies of the insulin binding site of the insulin receptor (IR) and the insulin-like growth factor 1 receptor (IGF-1R). More particularly, the present invention relates to the crystal structure of the low affinity insulin binding site of the IR ectodomain comprising the C-terminal region of the IR ?-chain, as well as the corresponding region of IGF-1R, and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the function of IR and/or IGF-1R.
    Type: Application
    Filed: March 9, 2010
    Publication date: May 17, 2012
    Inventors: Michael Colin Lawrence, Brian John Smith, John Gerbrandt Tasman Menting, Colin Wesley Ward
  • Structure of the Insulin Receptor Ectodomain
    Publication number: 20100267927
    Abstract: The present invention relates to the crystal structure of the insulin receptor ectodomain, to the nature of its N-linked glycans and to methods of using the crystal and related structural information to screen for and design compounds that interact with or modulate the insulin receptor and/or the closely-related insulin-like growth factor receptors or variants thereof.
    Type: Application
    Filed: June 22, 2007
    Publication date: October 21, 2010
    Inventors: Thomas P.J. Garrett, Timothy Edward Admas, George Lovrecz, Neil Moreton McKern, Michael Colin Lawrence, Lindsay Gale Sparrow, Colin Wesley Ward, Meizhen Lou, Victor Strelstov