Abstract: Methods and systems for the detection, identification, analysis of cybersecurity events in order to support prevention of the persistence of threats, malware or other harmful events are provided. The methods and systems of the present invention enable a user to find similar anomalous network traffic within a single network or across multiple networks. The methods and systems identify and correlate activity in order to analyze potential threats within a network by providing broader contextual information about how those threats relate to other activity within the network or across a sector or country.

Abstract: Methods and systems for the detection, identification, analysis of cybersecurity events in order to support prevention of the persistence of threats, malware or other harmful events are provided. The methods and systems of the present invention enable a user to find similar anomalous network traffic within a single network or across multiple networks. The methods and systems identify and correlate activity in order to analyze potential threats within a network by providing broader contextual information about how those threats relate to other activity within the network or across a sector or country.

Abstract: Systems and methods providing for determining physical location of a device of a user of an augmented reality environment corresponding to a physical space. The systems and methods involve requesting and receiving a list of participating users having a GPS location within a predetermined radius of a first device; sending advertising and scanning beacons, via a first wireless network, to generate a second list of devices present in the physical space; performing simultaneous localization and mapping (SLAM) using the participating devices of the second list; generating a third list based at least partly on a Bluetooth connection between the one or more participating devices of the second list; and identifying the participating devices of the third list.

Abstract: Systems and methods providing for determining physical location of a device of a user of an augmented reality environment corresponding to a physical space. The systems and methods involve requesting and receiving a list of participating users having a GPS location within a predetermined radius of a first device; sending advertising and scanning beacons, via a first wireless network, to generate a second list of devices present in the physical space; performing simultaneous localization and mapping (SLAM) using the participating devices of the second list; generating a third list based at least partly on a Bluetooth connection between the one or more participating devices of the second list; and identifying the participating devices of the third list.

Abstract: Systems and methods providing for determining physical location of a device of a user of an augmented reality environment corresponding to a physical space. The systems and methods involve requesting and receiving a list of participating users having a GPS location within a predetermined radius of a first device; sending advertising and scanning beacons, via a first wireless network, to generate a second list of devices present in the physical space; performing simultaneous localization and mapping (SLAM) using the participating devices of the second list; generating a third list based at least partly on a Bluetooth connection between the one or more participating devices of the second list; and identifying the participating devices of the third list.

Abstract: Methods and systems for the detection, identification, analysis of cybersecurity events in order to support prevention of the persistence of threats, malware or other harmful events are provided. The methods and systems of the present invention enable a user to find similar anomalous network traffic within a single network or across multiple networks. The methods and systems identify and correlate activity in order to analyze potential threats within a network by providing broader contextual information about how those threats relate to other activity within the network or across a sector or country.

Abstract: Systems and methods providing for determining physical location of a device of a user of an augmented reality environment corresponding to a physical space. The systems and methods involve requesting and receiving a list of participating users having a GPS location within a predetermined radius of a first device; sending advertising and scanning beacons, via a first wireless network, to generate a second list of devices present in the physical space; performing simultaneous localization and mapping (SLAM) using the participating devices of the second list; generating a third list based at least partly on a Bluetooth connection between the one or more participating devices of the second list; and identifying the participating devices of the third list.

Abstract: The present invention includes a high throughput screen for an active agent for the treatment of comprising: plating cells at least one pathophysiologically relevant mislocated mutant form of a peroxisomal enzyme; adding a control and compound to each plate from a library of compounds; fixing the cells; contacting the cells with an agent that detects the mislocated mutant form of a peroxisomal enzyme; and imaging the cells in the wells.

Abstract: A remote jettison system is provided to disconnect a mine roller from a tactical vehicle. The system enables personnel conducting mine roller operations to disengage the vehicle from the mine roller without leaving the vehicle. The remote jettison system has two assemblies: A mine roller assembly and a tactical vehicle assembly. The mine roller assembly, which is connected to the mine roller, can be remotely disconnected from the tactical vehicle assembly, which is mounted on the vehicle. The system utilizes one mechanized latch to release the mine roller assembly from the tactical vehicle assembly, allowing the force of gravity to cause them to separate.

Abstract: This application relates to methods of identifying pharmacoperone agents that can restore function to a misfolded protein, such as a misfolded protein that causes disease. Also disclosed are methods of using such pharmacoperone agents to treat a disease or disorder that results from the misfolded protein.

Abstract: This application relates to methods of identifying pharmacoperone agents that can restore function to a misfolded protein, such as a misfolded protein that causes disease. Also disclosed are methods of using such pharmacoperone agents to treat a disease or disorder that results from the misfolded protein.

Abstract: Herein disclosed is a method of rescuing gonadotropin-releasing hormone receptor (GnRHR) mutants with IN3 or a mimetic thereof. IN3 significantly rescues 11 missense mutations as assessed by radioligand binding and by IP production. Such rescue occurred despite widely disparate loci along the receptor. In addition, many altered GnRH receptors (terminally truncated, internal deletions, or lacking the ability to form bridges to form tertiary structure) were rescued with IN3.

Abstract: Herein disclosed is a method of rescuing gonadotropin-releasing hormone receptor (GnRHR) mutants with IN3 or a mimetic thereof. IN3 significantly rescues 11 missense mutations as assessed by radioligand binding and by IP production. Such rescue occurred despite widely disparate loci along the receptor. In addition, many altered GnRH receptors (terminally truncated, internal deletions, or lacking the ability to form bridges to form tertiary structure) were rescued with IN3.

Abstract: A method of detecting computer security threats. A first step involves providing a reference database of selected parameters to be monitored relating to one of human behaviour when operating a computer or software behaviour during operation of a computer. A second step involves monitoring one of human behaviour or software behaviour originating from a selected computer over a time interval. A third step involves comparing the monitored behaviours to the selected parameters in the reference database and determining the presence or absence of a potential security threat from such comparison.

Abstract: The present invention relates to a method for screening and identifying test compounds that bind to a preselected target ribonucleic acid (“RNA”). Direct, non-competitive binding assays are advantageously used to screen bead-based libraries of compounds for those that selectively bind to a preselected target RNA. Binding of target RNA molecules to a particular test compound is detected using any physical method that measures the altered physical property of the target RNA bound to a test compound. The structure of the test compound attached to the labeled RNA is also determined. The methods used will depend, in part, on the nature of the library screened. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads.

Abstract: The present invention relates to a method for screening and identifying test compounds that bind to a preselected target ribonucleic acid (“RNA”). Direct, non-competitive binding assays are advantageously used to screen bead-based libraries of compounds for those that selectively bind to a preselected target RNA. Binding of target RNA molecules to a particular test compound is detected using any physical method that measures the altered physical property of the target RNA bound to a test compound. The structure of the test compound attached to the labeled RNA is also determined. The methods used will depend, in part, on the nature of the library screened. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads.

Abstract: Herein disclosed is a method of rescuing gonadotropin-releasing hormone receptor (GnRHR) mutants with IN3 or a mimetic thereof. IN3 significantly rescues 11 missense mutations as assessed by radioligand binding and by IP production. Such rescue occurred despite widely disparate loci along the receptor. In addition, many altered GnRH receptors (terminally truncated, internal deletions, or lacking the ability to form bridges to form tertiary structure) were rescued with IN3.

Abstract: A synthetic hormone complex comprising means for binding to the surface of a cell and means for altering second messenger mobilization by the cell. One form of the synthetic hormone complex functions as an antagonist with specific binding affinity for a cell receptor, said hormone in combination with a calcium ion channel inhibitor. Another synthetic hormone complex functioning as an Agonist comprising two or more molecules of a hormone having specific binding affinity for a cell receptor wherein a spacer binding the hormones is 10 to 300 angstroms in length. A method of regulating hormones or other regulatory factors comprising contacting a synthetic hormone complex with a cell surface or internal receptor thereby altering the incorporation of second messenger molecules thereby regulating the physiological function of the cell.