Abstract: Described herein are compounds of Formula (I) that are inhibitors of mTORC1, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.

Abstract: The disclosure relates to compounds of formula (I) and pharmaceutically acceptable salts, and compositions thereof, wherein the substituents are as defined herein. Also provided are methods of making compounds of formula (I), and methods involving the compounds or compositions for treating disorders and diseases described herein.

Abstract: The disclosure provides 32-deoxo-rapamycin derivatives of Formula (I), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions and pharmaceutical combinations comprising a compound of Formula (I), and methods of making same. Also provided herein are methods of using a compound of Formula (I) or a pharmaceutically acceptable salt thereof for treating the diseases and disorders described herein.

Abstract: The disclosure relates to compounds of formula (I) and pharmaceutically acceptable salts, and compositions thereof, wherein the substituents are as defined herein. Also provided are methods of making compounds of formula (I), and methods involving the compounds or compositions for treating disorders and diseases described herein.

Abstract: A bed linen combination for use on a mattress. The combination includes a bottom fitted sheet having a first side, an opposing second side, a top edge and a foot-end which is sized and shaped to fit over the mattress. The combination also includes a top flat sheet attached to the bottom fitted sheet at the foot-end and a portion of the first and second sides of the bottom fitted sheet at first and second side attachment segments. Tags may also be affixed at the ends of the side attachment segments to the top flat sheet and bottom fitted sheet. In another embodiment of the present invention, a blanket may be magnetically held in place at the foot-end of the top flat sheet and bottom fitted sheet.

Abstract: A monitoring device provided for monitoring the delivery of fluids through a drip chamber. The device includes an electromagnetic radiation (EMR) source and an EMR detector. The device includes a tubing set mount for receiving a flange or other portion of a tubing set, such that fluid falling through the drip chamber of the tubing set is detected by the detector. The device is operable to determine one or more rolling averages based on intervals of drops or time.

Abstract: The disclosure relates to compounds of formula (I) and pharmaceutically acceptable salts, and compositions thereof, wherein the substituents are as defined herein. Also provided are methods of making compounds of formula (I), and methods involving the compounds or compositions for treating disorders and diseases described herein.

Abstract: Described herein are compounds of Formula (I) that are inhibitors of mTORC1, pharmaceutical compositions including such compounds, and methods of using such compounds and compositions.

Abstract: The disclosure provides 32-deoxo-rapamycin derivatives of Formula (I), or a pharmaceutically acceptable salt thereof, pharmaceutical compositions and pharmaceutical combinations comprising a compound of Formula (I), and methods of making same. Also provided herein are methods of using a compound of Formula (I) or a pharmaceutically acceptable salt thereof for treating the diseases and disorders described herein.

Abstract: The disclosure relates to compounds of formula (I) and pharmaceutically acceptable salts, and compositions thereof, wherein the substituents are as defined herein. Also provided are methods of making compounds of formula (I), and methods involving the compounds or compositions for treating disorders and diseases described herein.

Abstract: A monitoring device provided for monitoring the delivery of fluids through a drip chamber. The device includes an electromagnetic radiation source and a radiation detector. A weight detector is positioned to determine the weight of a fluid reservoir over time, and the detector is positioned with respect to the drip chamber to detect drops falling through the drip chamber. A processor is coupled to the radiation detector and the weight detector to determine flow rate, and is further coupled to a flow restrictor to selectively increase or decrease flow based on the determined flow rate.

Abstract: The disclosure relates to compounds of formula (I) and pharmaceutically acceptable salts, and compositions thereof, wherein the substituents are as defined herein. Also provided are methods of making compounds of formula (I), and methods involving the compounds or compositions for treating disorders and diseases described herein.

Abstract: A monitoring device provided for monitoring the delivery of fluids through a drip chamber. The device includes an electromagnetic radiation (EMR) source and an EMR detector. The device includes a tubing set mount for receiving a flange or other portion of a tubing set, such that fluid falling through the drip chamber of the tubing set is detected by the detector. The device is operable to determine one or more rolling averages based on intervals of drops or time.

Abstract: A monitoring device provided for monitoring the delivery of fluids through a drip chamber. The device includes an electromagnetic radiation (EMR) source and an EMR detector. The device includes a tubing set mount for receiving a flange or other portion of a tubing set, such that fluid falling through the drip chamber of the tubing set is detected by the detector.

Abstract: A monitoring device provided for monitoring the delivery of fluids through a drip chamber. The device includes an electromagnetic radiation (EMR) source and an EMR detector. The device includes a tubing set mount for receiving a flange or other portion of a tubing set, such that fluid falling through the drip chamber of the tubing set is detected by the detector.

Abstract: A device provided for monitoring the delivery of fluids through a drip chamber. The device includes an electromagnetic radiation (EMR) source and an EMR detector. A device body is employed to position the source and detector about the drip chamber so that the source and detector define an optical path across the drip chamber. A processor device is employed to detect fluid drops from differences between detector signal values separated by a lag time. The device connects to a monitor which may continuously monitor the detected drips.

Abstract: The disclosure relates to compounds of formula (I) and pharmaceutically acceptable salts, and compositions thereof, wherein the substituents are as defined herein. Also provided are methods of making compounds of formula (I), and methods involving the compounds or compositions for treating disorders and diseases described herein.

Abstract: Systems and methods that provide for a virtual reality entertainment system that supplies immersive entertainment and creates a sensation for a user similar to having guests in a remote location to be physically present as virtual guests. Such virtual reality entertainment system can supply a graphic and/or audio; wherein interconnected computers, video and audio processing devices, supply a live interaction between a user and a guest(s). Although guests are only present virtually (e.g., electronically present with other objects/user within the environment) such virtual invitation enables a user and guests to concurrently experience the entertainment together (e.g., a live sporting event, spectator game). In a related aspect, the subject innovation can implement holographic avatars, and a plurality of communication interfaces, to imitate (and/or transform) a relationship between the user and the virtual guests/surrounding environment.

Abstract: A device provided for monitoring the delivery of fluids through a drip chamber. The device includes an electromagnetic radiation (EMR) source and an EMR detector. A device body is employed to position the source and detector about the drip chamber so that the source and detector define an optical path across the drip chamber. A processor device is employed to detect fluid drops from differences between detector signal values separated by a lag time. The device connects to a monitor which may continuously monitor the detected drips.