Abstract: Compositions and methods for binding to a target sequence of interest are provided. The compositions find use in cleaving or modifying a target sequence of interest, visualization of a target sequence of interest, and modifying the expression of a sequence of interest. Compositions comprise RNA-guided nuclease (RGN) polypeptides, CRISPR RNAs, trans-activating CRISPR RNAs, guide RNAs, and nucleic acid molecules encoding the same. Vectors and host cells comprising the nucleic acid molecules are also provided. Further provided are RGN systems for binding a target sequence of interest, wherein the RGN system comprises an RNA-guided nuclease polypeptide and one or more guide RNAs.

Abstract: Controlled motion capsules and associated systems and methods are described. Controlled motion capsules can decelerate, and stop, without damaging epithelial walls. If any components fail, a controlled motion capsule, without added energy, becomes its most compact shape, passing harmlessly through the GI tract. Controlled motion capsule may include a shape changing material, comprising a reversible soft copolymer, in a container in the capsule, with a nonionizing radiation emitter, and a controller to activate the nonionizing radiation to expand and contract the shape changing material, on detection of certain conditions or instructions. Expansion of the shape changing material, including contact with epithelial walls, decelerates and can stop the controlled motion capsule movement. Motion control allows scientists to study the microbiome, doctors to deliver intestinal drugs at precise locations, and to closely examine signs of precancerous growth.

Abstract: Compositions and methods for binding to a target sequence of interest are provided. The compositions find use in cleaving or modifying a target sequence of interest, visualization of a target sequence of interest, and modifying the expression of a sequence of interest. Compositions comprise RNA-guided nuclease polypeptides, CRISPR RNAs, trans-activating CRISPR RNAs, guide RNAs, and nucleic acid molecules encoding the same. Vectors and host cells comprising the nucleic acid molecules are also provided. Further provided are CRISPR systems for binding a target sequence of interest, wherein the CRISPR system comprises an RNA-guided nuclease polypeptide and one or more guide RNAs. Methods and kits for detecting a target DNA sequence are also provided.

Abstract: The present invention is a helmet system that reduces concussions by damping rotational force transmitted to a helmet user. The helmet has an exterior shell and an internal body that moves independently from the exterior shell. At least one magnetic source on the exterior shell's interior has a dipole directed axially at the internal body. At least one magnetic source on the internal body has a dipole aligned with the same axis, directed at the exterior shell. In a resting state magnetic sources generate a weak magnetic field. When an impact rotates the exterior shell, it moves off the initial alignment and closer to the internal body. The previously aligned magnetic sources torque. The magnetic source on the internal body torques in the opposite direction of the rotation, as do all initially aligned magnetic sources impacted. Angular momentum is displaced, diffused, offset, damping rotational force transmitted to a helmet user.

Abstract: The present invention is a helmet system that reduces concussions by damping rotational force transmitted to a helmet user. The helmet has an exterior shell and an internal body that moves independently from the exterior shell. At least one magnetic source on the exterior shell's interior has a dipole directed axially at the internal body. At least one magnetic source on the internal body has a dipole aligned with the same axis, directed at the exterior shell. In a resting state magnetic sources generate a weak magnetic field. When an impact rotates the exterior shell, it moves off the initial alignment and closer to the internal body. The previously aligned magnetic sources torque. The magnetic source on the internal body torques in the opposite direction of the rotation, as do all initially aligned magnetic sources impacted. Angular momentum is displaced, diffused, offset, damping rotational force transmitted to a helmet user.

Abstract: Compositions and methods for binding to a target sequence of interest are provided. The compositions find use in cleaving or modifying a target sequence of interest, visualization of a target sequence of interest, and modifying the expression of a sequence of interest. Compositions comprise RNA-guided nuclease polypeptides, CRISPR RNAs, trans-activating CRISPR RNAs, guide RNAs, and nucleic acid molecules encoding the same. Vectors and host cells comprising the nucleic acid molecules are also provided. Further provided are CRISPR systems for binding a target sequence of interest, wherein the CRISPR system comprises an RNA-guided nuclease polypeptide and one or more guide RNAs.

Abstract: An acoustic wavefront shaping device for altering the propagation of emergency siren sounds is provided. The device includes an enclosed framework containing sound channels mounted before a siren horn. The sound channels are positioned to partition the spherical wavefronts emitted by the siren and transmit each wavelet from the channel's entrance to exit into free space. The interior space of the sound channels contain acoustic macroscopic metamaterial structures that direct wavelet acoustic energy on meandering paths, which extend the transmission duration. Channels higher up in the framework, and away from the center, have straighter paths that transmit acoustic energy more quickly than other channels. The wavelets exit the channels at different times and reconfigure to form a wavefront that is squat and narrow, compared to spherical wavefronts. This wavefront expands into free space staying closer to the ground and closer to the center of the road than spherical wavefront expansion.

Abstract: A fine cover particularly for use with respirator facemasks comprises one or more components, each defined by a perimeter, holding flexible, breathable material. The components expand to cover part of a respirator facemask and fold smoothly to close exposed surfaces during removal, thereby preventing pathogen shedding. The cInstitute of Medicine, 2006 Reusability of Facemasks During an Influenza Pandemic: Facing the Flu; losed unit is placed in a bag for cleaning, disposal, or testing. Samples taken from fine cover can be tested to detect airborne pathogens, an optimal airborne pathogen monitoring system in medical facilities. In addition, the fine cover may have graphical imagery to directs an observer's gaze in the same patterns followed when looking at an unmasked face, thereby reducing subconscious interaction anxiety.

Abstract: Compositions and methods for binding to a target sequence of interest are provided. The compositions find use in cleaving or modifying a target sequence of interest, visualization of a target sequence of interest, and modifying the expression of a sequence of interest. Compositions comprise RNA-guided nuclease polypeptides, CRISPR RNAs, trans-activating CRISPR RNAs, guide RNAs, and nucleic acid molecules encoding the same. Vectors and host cells comprising the nucleic acid molecules are also provided. Further provided are CRISPR systems for binding a target sequence of interest, wherein the CRISPR system comprises an RNA-guided nuclease polypeptide and one or more guide RNAs.

Abstract: The present disclosure relates to a photodental device that can deliver specific light wavelengths to animal oral cavities, particularly dogs. The device may be provided in a variety of shapes, sizes, and materials, for breeds from under 2 kg (4.4 lbs) to over 115 kg (254 lbs). The device has a container which may protect light sources and may be used to receive light transmission, comprising an illuminating member. The device can further include replaceable housings with photoactivated compounds. The device may be configured for untethered use by an animal. Alternatively, the electro-optical components can be placed in a separate body and transmit light through a tethered connection to a member used by an animal. Sensor components may activate light generation components in predetermined conditions. Alternatively, humans may control activation. The present disclosure also relates to methods of photodentistry using the photodental device as bactericidal treatment and periodontal treatment.

Abstract: A mask-on-a-stick includes a holding part and a mask unit which are connected, in which the mask unit has a curved shape. When a user is holding the mask-on-a-stick, the mask unit fits naturally over their mouth and lower nose, and the mask unit surface prevents the user from spreading microbial particles to the environment. The widest part of the mask unit fits over the user's mouth, and above this area the mask unit extends to cover the lower nose. The mask-on-a-stick can be manufactured from cellulose-based material at reasonable cost, so as to be disposable, or recyclable after sterilizing, and numerous sizes of the mask-on-a-stick may be made available for customers at restaurants and other locations where people remove facemasks to eat or drink, but need to cover their mouth and nose when talking.

Abstract: The present invention relates to methods, systems, and devices that emit light energy in the ruminant rumenoreticulum, to inactivate a quantity of bacteria equivalent to the quantity inactivated by sub-therapeutic doses of antibiotics. The device is a size or shape that will obtain a predetermined position within the rumenoreticulum, and protectively contains long lasting battery power, electric components, and light sources that emit wavelengths that inactivate and destroy bacteria. The device, the system and the method according to the present invention also allow detection of biological parameters of the capsule environment and communication with a receiver outside the animal.

Abstract: An acoustic wavefront shaping device for altering the propagation of emergency siren sounds is provided. The device includes an enclosed framework containing sound channels mounted before a siren horn. The sound channels are positioned to partition the spherical wavefronts emitted by the siren and transmit each subwavelength portion from the channel's entrance to exit into free space. The interior space of the sound channels contain acoustic meta-atoms that direct subwavelength acoustic energy on meandering paths, which extend the transmission duration. Channels higher up in the framework, and away from the center, have straighter paths that transmit acoustic energy more quickly than other channels. The subwavelength segments exit the channels at different times and reconfigure to form a wavefront that is squat and narrow, compared to spherical wavefronts. This wavefront expands into free space staying closer to the ground and closer to the center of the road than spherical wavefront expansion.

Abstract: The disclosed computer-implemented method for displaying search results may include (1) receiving a search query to search a document database that stores a document family containing a parent document and a child document that depends from the parent document, (2) determining that both the parent document and the child document satisfy a degree of relevance to content of the search query, and (3) in response to determining that both the parent document and the child document satisfy the degree of relevance to content of the search query, automatically depicting both the parent document and the child document in a hierarchical structure that shows the relationship between the parent document and the child document within original search results that a user interface of a computing device presents in response to the search query. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: The present invention is a helmet system that reduces concussions by damping rotational forces transmitted to a helmet wearer's head. The helmet has an exterior shell with an internal side that has impact absorption apparatus attached. The helmet also has an internal body worn close to the wearer's head. A gap between the internal body and the impact absorption apparatus close to the shell is maintained with flexible projections. At least one magnet assembly is located with the exterior shell absorption apparatus, with a magnetic pole extending axially inwards, and at least one magnet array is located with the internal body, with the same magnetic pole extending axially outwards. Each internal body magnetic field is axially aligned with a magnetic field of a respective magnet assembly located with the exterior shell absorption apparatus. In a resting state the aligned magnetic fields have little magnetic interaction.

Abstract: Compositions and methods for binding to a target sequence of interest are provided. The compositions find use in cleaving or modifying a target sequence of interest, visualization of a target sequence of interest, and modifying the expression of a sequence of interest. Compositions comprise RNA-guided nuclease polypeptides, CRISPR RNAs, trans-activating CRISPR RNAs, guide RNAs, and nucleic acid molecules encoding the same. Vectors and host cells comprising the nucleic acid molecules are also provided. Further provided are CRISPR systems for binding a target sequence of interest, wherein the CRISPR system comprises an RNA-guided nuclease polypeptide and one or more guide RNAs.

Abstract: The present disclosure relates to a photodental device that can deliver specific light wavelengths to animal oral cavities, particularly dogs. The device may be provided in a variety of shapes, sizes, and materials, for breeds from under 2 kg (4.4 lbs) to over 115 kg (254 lbs). The device has a container which may protect light sources and may be used to receive light transmission, comprising an illuminating member. The device can further include replaceable housings with photoactivated compounds. The device may be configured for untethered use by an animal. Alternatively, the electro-optical components can be placed in a separate body and transmit light through a tethered connection to a member used by an animal. Sensor components may activate light generation components in predetermined conditions. Alternatively, humans may control activation. The present disclosure also relates to methods of photodentistry using the photodental device as bactericidal treatment and periodontal treatment.

Abstract: A solid fuel nozzle tip for issuing a flow of mixed solid fuel and air to a boiler includes a tip body having an inlet and an outlet defining a longitudinal axis therebetween. The tip body includes a slot on an inlet side of the tip body extending in a direction parallel to the longitudinal axis. The slot includes an opening facing the inlet side of the tip body and a recess formed at an angle with respect to the longitudinal axis to at least partially retain a pivot pin. A solid fuel nozzle assembly for issuing a flow of mixed solid fuel and air to a boiler includes a solid fuel nozzle tip with a tip body, as described above, and a locking plate operatively connected to the tip body to assist in retaining a pivot pin within the slot of the tip body.

Abstract: A disclosed computer-implemented method for displaying search results may include (1) receiving a query to search a document database that stores a document family containing a parent document and a child document embedded within the parent document, (2) in response to receiving the search query, identifying (a) an individual relevance score that quantifies the relevance of the parent document to the search query and (b) a family relevance score that quantifies the overall relevance of the entire document family to the search query, and (3) simultaneously depicting both the individual relevance score and the family relevance score in response to the search query. Various other methods, systems, and computer-readable media are also disclosed.

Abstract: A computer-implemented method for expanding search results may include (1) determining that a user is attempting to perform a search, (2) presenting an option to the user to include, within results of the search, a document family associated with a found document, (3) determining that the user has selected to include the document family associated with the document, and (4) including the document family in the search results in response to determining that the user has selected to include the document family associated with the document. Various other methods, systems, and computer-readable media are also disclosed.