Abstract: The present disclosure generally relates to auditory nerve stimulation to create the perception of sound in the brain of a subject such as an animal or human being. In one form, a system includes an implantable electrode array including a plurality of spaced apart micro-needles. The system also includes a first electrical lead electrically coupled to and extending from the implantable electrode array, and an auditory signal device configured to produce one or more electrical signals representative of communications received from an external processor. An interposer is configured to electrically couple the implantable electrode array and the auditory signal device in an arrangement where one or more electrical signals produced by the auditory signal device may be transmitted through the first electrical lead to the implantable electrode array. Various novel stimulation strategies can be employed, such as place modulated stimulation signals.

Abstract: In alternative embodiments, provided are methods for treating and ameliorating a cancer, or recurrence of a cancer such as acute myeloid leukemia (AML) comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 (or rebecsinib) and second drug such as an ATP-competitive protein tyrosine kinase inhibitor such as dasatinib. In alternative embodiments, provided are methods for the in vivo inhibition of myeloproliferative neoplasm (MPN) or AML stem cell propagation comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 and second drug. In alternative embodiments, provided are methods for the in vivo inhibition pre-leukemia stem cell (pre-LSC) transformation into leukemia stem cells (LSCs) comprising administration to an individual in need thereof a pharmaceutical composition comprising 17S-FD-895 and second drug.

Abstract: This invention provides a method for updating a document module for use with an application program on a remote computer from a host computer. The method includes the steps of creating a document module and storing the document module at a resource center, associating the document module with a time-dependent unique identifier. The method includes the further steps of comparing the time dependent unique identifier associated with the document module at the remote device to the identifier at the resource center, and transmitting the document module at the resource center when the version on the remote computer is superseded.

Abstract: A portable computer and corresponding docking station, where the portable computer may be inserted into or removed from the docking station without concern relating to the state of either the portable computer or of the docking station. The hot docking sequence is performed by establishing a direct connection to the primary PCI bus without the risk of any possible system damage, file damage, or data loss. This can be accomplished even while the portable computer system is powered on and is actively running. The present invention prevents glitches from occurring in pre-existing pins and adds four new pins to implement this novel hot docking sequence. Furthermore, hot undocking can be readily performed as well by basically reversing the docking sequence.