Abstract: Disclosed herein are methods, pharmaceutical compositions, and vaccines for modulating an immune response. Also disclosed herein are methods, pharmaceutical compositions, and vaccines for inducing an immune response.

Abstract: A near isothermal machine for compressing or expanding gas having a piston in a main cylinder with a heat absorbing and releasing structure attached thereto. The main cylinder contains a substantially constant volume of liquid maintained at a substantially constant temperature and a variable volume of gas, the gas temperature being controlled to substantially the same temperature as the liquid by the movement with the piston of the heat absorbing and releasing structure. A compensator is provided to compensate for variations in the level of liquid as the piston moves in the main cylinder.

Abstract: Apparatuses, capacitor arrays, and methods for generating therapeutic compressed acoustic waves (e.g., shock waves). In the apparatuses and at least some of the methods, a plurality of electrodes can disposed in a chamber that is defined by a housing and configured to be filled with liquid, and a plurality of capacitors can be electrically connected to the electrodes and can be carried by (e.g., physically coupled to) the housing. Voltage pulses can be applied simultaneously to the plurality of electrodes (e.g., to begin to vaporize and ionize portions of the liquid to provide at least one inter-electrode conductive path between the plurality of electrodes) and to the capacitors to charge the plurality of capacitors). The plurality of capacitors can be configured to, upon reaching a threshold charge, discharge to the plurality of electrodes (e.g.

Abstract: Frequency ranges may be converted by an apparatus including a converter configured to shift an original frequency range of an input data signal to a target frequency range, an input band selective filter bank configured to route the input data signal through a bandpass filter of a selected subrange within the target frequency range, the input selective filter bank including a plurality of bandpass filters, each bandpass filter having a corresponding subrange within the target frequency range.

Abstract: The present invention is a nebulizer, aerosol, filter or inhalant handheld system. The device is composed of a non-invasive respiratory circuit with a medication reservoir that has an inlet that is configured to be connected to a gas source. In some embodiments, they include of one or more valves located downstream of the medication reservoir. Some embodiments include one or more filters, such as a bacterial viral filter located on the end of the exhalation port. The valve functions to prevent backflow of exhaled air and/or potential pathogens into the atmosphere. The filter functions to significantly reduce the dispersion of aerosols exhaled into the atmosphere and prevent further spread of potential pathogens. Some embodiment may include one or more pivotable elements allowing some portions of the nebulizer to pivot relative to other members.

Abstract: A valve apparatus for an aircraft fluid system is disclosed including a valve housing and a valve member. The valve member is configured to move between a first position in which fluid is able to flow along the fluid flow path, and a second position in which the fluid flow path restricted. A valve member drive means is configured to operate the valve member via an actuator external to the housing. The valve apparatus further includes a sensor configured to monitor a feature in the housing to determine the position of the valve member.

Abstract: A method comprising optically detecting optical output states of a plurality of light sources of an optical device over a test interval; for each light source, optically detecting that the output state of the light source has changed from a first optical condition to a second optical condition; for each light source, optically detecting that the output state of the light source has changed from the second optical condition to a third optical condition; for each light source, determining a first time interval representative of the first optical condition; for each light source, determining a second time interval representative of the second optical condition; for each light source, determining a third time interval representative of the third optical condition; determining a test result for the device based on a comparison of the first, second and third time intervals with pre-stored time intervals.

Abstract: A machine for compressing or expanding gas comprises a piston operating downwards in a compression stroke with respect to an inclined or vertical cylinder and upwards with respect to the cylinder in an expansion stroke. The piston has a heat absorbing and releasing structure attached to its bottom face. There is a gap between the piston and the base of the cylinder when the gas volume in the cylinder is at its minimum. The gap contains a hydraulic fluid which absorbs heat from the heat absorbing and releasing structure. A heat transfer surface containing fluid circulating to and from an external source maintains the hydraulic fluid at constant temperature. In one arrangement the heat absorbing and releasing structure comprises thin sheets of aluminium attached orthogonally to the bottom face of the piston.

Abstract: Devices and methods for administering a therapeutic agent, including an implantable delivery device. Exemplary embodiments include a reservoir in fluid communication with a channeled member, and a compound including the therapeutic agent and a solubilizer disposed within the reservoir.

Abstract: A valve apparatus for an aircraft fluid system is disclosed including a valve housing and a valve member. The valve member is configured to move between a first position in which fluid is able to flow along the fluid flow path, and a second position in which the fluid flow path restricted. A valve member drive means is configured to operate the valve member via an actuator external to the housing. The valve apparatus further includes a sensor configured to monitor a feature in the housing to determine the position of the valve member.

Abstract: A machine for compressing or expanding gas comprises a piston operating downwards in a compression stroke with respect to an inclined or vertical cylinder and upwards with respect to the cylinder in an expansion stroke. The piston has a heat absorbing and releasing structure attached to its bottom face. There is a gap between the piston and the base of the cylinder when the gas volume in the cylinder is at its minimum The gap contains a hydraulic fluid which absorbs heat from the heat absorbing and releasing structure. A heat transfer surface containing fluid circulating to and from an external source maintains the hydraulic fluid at constant temperature. In one arrangement the heat absorbing and releasing structure comprises thin sheets of aluminium attached orthogonally to the bottom face of the piston.

Abstract: A method comprising optically detecting optical output states of a plurality of light sources of an optical device over a test interval; for each light source, optically detecting that the output state of the light source has changed from a first optical condition to a second optical condition; for each light source, optically detecting that the output state of the light source has changed from the second optical condition to a third optical condition; for each light source, determining a first time interval representative of the first optical condition; for each light source, determining a second time interval representative of the second optical condition; for each light source, determining a third time interval representative of the third optical condition; determining a test result for the device based on a comparison of the first, second and third time intervals with pre-stored time intervals.

Abstract: A visible LED light scattering apparatus comprising a substantially hollow spherical cavity including a light entry port arranged to receive visible light from an LED mounted outside the cavity, a light exit port located opposite the entry port and through which the LED light exits the cavity for analysis, and a baffle located in a central region of the cavity in a direct optical path between the entry port and the exit port to interrupt the passage of visible LED light between the entry and exit ports.

Abstract: Devices and methods for administering a therapeutic agent, comprising an implantable delivery device. Exemplary embodiments comprise a reservoir in fluid communication with a channeled member, and a compound comprising the therapeutic agent and a solubilizer disposed within the reservoir.

Abstract: An apparatus for testing light emitting diodes (LEDs) comprising a chamber which is configured to heat or cool LEDs inside the chamber by ambient heating or cooling of the LEDs and an optical sensing unit configured to sense light emitted by the LEDs while the LEDs are inside the chamber. A method for testing LEDs is also described.

Abstract: An imaging system (1) comprises a transmitter (3, 6), a receiver (3, 4, 6), an antenna array (2); and a controller (4, 5, 10, 11) for directing the transmitter, the receiver, and the antenna array to scan a volume containing an object. The controller has multiple distributed processors (15) to calculate antenna control pattern data during run-time. The processor (4, 5) assesses misalignment of antennae using a receiver placed in the imaging volume, and monitors level of energy received by the receiver and compares it with a reference energy level. Also, the controller performs on-the-fly modification of antenna control pattern data according to real time conditions such as mechanical misalignment of the transmitter, the receiver, or of one or more antennas. The controller may generate three-dimensional offset vectors to provide a profile of the offset across the scan volume, and the position of an antenna may be moved to compensate for the mechanical misalignment.

Abstract: The invention concerns a co-processed additive for a solid-dose pharmaceutical composition, the additive comprising from about 50% to 99.5% by weight of at least one pharmaceutical compression aid and from about 0.5% to 50% by weight of at least one pharmaceutical lubricant, the melting point of said compression aid(s) being higher than the melting point of said lubricant(s). The co-processed additive may be in the form of a physically bound composite whereby the lubricant is associated with the surface of the compression aid particles.

Abstract: The invention relates to an imaging system having a reflect array for reflection of radiation such as millimeter-wave radiation. It can apply to imaging systems which operate over a wide range of wavelengths.

Abstract: An aircraft refuelling system of an aircraft is provided. The refuelling system comprises a refuelling connector (34) mounted as part of the aircraft and configured to detachably connect to the fuel outlet (2) of a fuel supply apparatus separate from the aircraft, and a fuel pressure regulator (36) having an inlet in communication with a fuel inlet (35) of the refuelling connector (34) and having an outlet in communication with refuelling pipework (39) of the aircraft. The fuel pressure regulator (36), regulates the pressure of fuel in the refuelling pipework (39) when fuel is being passed into the refuelling pipework (39) from the fuel inlet (35) of the refuelling connector.

Abstract: According to at least one embodiment, a system for discovering, configuring and monitoring automatic control devices is provided. The system includes a mobile computing device that implements a control device interface. The control device interface provides a discovery request to at least one automatic control device in data communication with a network, the discovery request being encoded according to a first protocol; provides a request for identification to the at least one automatic control device, the request for identification being encoded according to a second protocol; and identifies the at least one automatic control device as an automatic control device based on the response to the request for identification. In this embodiment, the second protocol is an industrial protocol.