Abstract: The present disclosure provides aseptic vial piercing and sterilization systems, and methods of assembling, using and sterilizing same. The systems and methods utilize a pre-sterilized primary container including a first end, a first cavity, a second end with an opening in communication with the first cavity, a septum at least partially sealing the opening, and a product within the first cavity. The systems and methods include an injection assembly including a first end portion of a hollow flowpath forming member. The injection assembly and the primary container may be assembled in a non-sterile environment to form a second cavity extending about the first end portion of the flowpath forming member and to the primary container. The second cavity may then be selectively sterilized in a non-deleterious manner to the product to allow the first end portion to aseptically pierce the septum to extend into the first cavity.

Abstract: The present disclosure provides aseptic vial piercing and sterilization systems, and methods of assembling, using and sterilizing same. The systems and methods utilize a pre-sterilized primary container including a first end, a first cavity, a second end with an opening in communication with the first cavity, a septum at least partially sealing the opening, and a product within the first cavity. The systems and methods include an injection assembly including a first end portion of a hollow flowpath forming member. The injection assembly and the primary container may be assembled in a non-sterile environment to form a second cavity extending about the first end portion of the flowpath forming member and to the primary container. The second cavity may then be selectively sterilized in a non-deleterious manner to the product to allow the first end portion to aseptically pierce the septum to extend into the first cavity.

Abstract: A syringe system, piston seal systems, stopper systems, and methods for assembling and using the syringe systems. The piston seal system including a piston seal member and a piston head member. The injection system including a container, a piston seal system positioned within the container, and a stopper system coupled to an end of the container. The method of assembling an injection system, the method includes obtaining a container, a piston seal system, and a stopper system. The method also includes inserting the piston seal system into a cavity within the container. The method further includes securing the stopper system at an end of the container in an opening of the cavity. Methods of using the syringe system, piston seal systems, and stopper systems are also disclosed.

Abstract: The present disclosure provides aseptic vial piercing and sterilization systems, and methods of assembling, using and sterilizing same. The systems and methods utilize a pre-sterilized primary container including a first end, a first cavity, a second end with an opening in communication with the first cavity, a septum at least partially sealing the opening, and a product within the first cavity. The systems and methods include an injection assembly including a first end portion of a hollow flowpath forming member. The injection assembly and the primary container may be assembled in a non-sterile environment to form a second cavity extending about the first end portion of the flowpath forming member and to the primary container. The second cavity may then be selectively sterilized in a non-deleterious manner to the product to allow the first end portion to aseptically pierce the septum to extend into the first cavity.

Abstract: The present disclosure provides aseptic vial piercing and sterilization systems, and methods of assembling, using and sterilizing same. The systems and methods utilize a pre-sterilized primary container including a first end, a first cavity, a second end with an opening in communication with the first cavity, a septum at least partially sealing the opening, and a product within the first cavity. The systems and methods include an injection assembly including a first end portion of a hollow flowpath forming member. The injection assembly and the primary container may be assembled in a non-sterile environment to form a second cavity extending about the first end portion of the flowpath forming member and to the primary container. The second cavity may then be selectively sterilized in a non-deleterious manner to the product to allow the first end portion to aseptically pierce the septum to extend into the first cavity.

Abstract: The present disclosure provides plunger rods including a shaft, an injection member and a contact member. The shaft has a first end and a second end, and the injection member is coupled to the shaft at the first end. The contact member is coupled to the shaft at the second end. The present disclosure also provides injection systems including a container, a piston and a plunger. The container has with a first end and a second end. The piston is positioned within the container, and the plunger rod is positioned within the container adjacent to the piston. The present disclosure also provides methods of assembling an injection system. The methods include obtaining a container, a piston, and a plunger rod. The methods further include inserting the piston into an opening in a second end of the container, and inserting the plunger rod into the opening in the second end of the container and positioning the plunger rod adjacent to the piston.

Abstract: The present disclosure provides aseptic vial piercing and sterilization systems, and methods of assembling, using and sterilizing same. The systems and methods utilize a pre-sterilized primary container including a first end, a first cavity, a second end with an opening in communication with the first cavity, a septum at least partially sealing the opening, and a product within the first cavity. The systems and methods include an injection assembly including a first end portion of a hollow flowpath forming member. The injection assembly and the primary container may be assembled in a non-sterile environment to form a second cavity extending about the first end portion of the flowpath forming member and to the primary container. The second cavity may then be selectively sterilized in a non-deleterious manner to the product to allow the first end portion to aseptically pierce the septum to extend into the first cavity.

Abstract: A syringe system, piston seal systems, stopper systems, and methods for assembling and using the syringe systems. The piston seal system including a piston seal member and a piston head member. The injection system including a container, a piston seal system positioned within the container, and a stopper system coupled to an end of the container. The method of assembling an injection system, the method includes obtaining a container, a piston seal system, and a stopper system. The method also includes inserting the piston seal system into a cavity within the container. The method further includes securing the stopper system at an end of the container in an opening of the cavity. Methods of using the syringe system, piston seal systems, and stopper systems are also disclosed.

Abstract: Drug delivery systems, vibratory drive mechanisms, and methods of using the systems and mechanisms are disclosed. The drug delivery system including an activation module, a vibrating mechanism electrically coupled to the activation module, a pumping mechanism connected to the activation module, a reservoir, and an injection mechanism coupled to the reservoir by at least one fluid pathway. The at least one fluid pathway extends through the pumping mechanism. The vibratory drive mechanism including an activation module, a vibrating mechanism electrically coupled to the activation module, and an actuation mechanism coupled to the vibrating mechanism. Methods of using a remotely activated drug delivery system are also disclosed.

Abstract: Aseptic drug delivery systems, drug delivery systems, drug delivery modules, and methods of manufacturing, assembling and using the systems are disclosed. The drug delivery system including a housing, a motion plate coupled to the housing, and a module moveably coupled to the motion plate. The drug delivery module including a plate with a first end and a second end, a cartridge positioned on the plate, and a cover positioned over the cartridge. Methods of manufacturing, assembling and using the aseptic drug delivery system and a method of manufacturing a drug delivery cartridge are also disclosed.

Abstract: A flat-folding mask includes a filter layer forming a rim. The filter layer has first and second side panels extending from the rim. A substantially centrally located front panel bridges the first and second side panels, the front panel being substantially flat. The filter layer further includes a fused portion that is seamless and spaced from the rim. Triangular pleats may add support to the side walls and increase the effective filtration area of the mask.

Abstract: A flat-folding mask includes a filter layer forming a rim. The filter layer has first and second side panels extending from the rim. A substantially centrally located front panel bridges the first and second side panels, the front panel being substantially flat. The filter layer further includes a fused portion that is seamless and spaced from the rim. Triangular pleats may add support to the side walls and increase the effective filtration area of the mask.

Abstract: A flat-folding mask includes a filter layer forming a rim. The filter layer has first and second side panels extending from the rim. A substantially centrally located front panel bridges the first and second side panels, the front panel being substantially flat. The filter layer further includes a fused portion that is seamless and spaced from the rim. Triangular pleats may add support to the side walls and increase the effective filtration area of the mask.

Abstract: A one-way fluid valve may include a valve base having a central portion with a post and an outer portion having a seat, a diaphragm having a central portion with an opening for receiving the post of the valve base, the diaphragm having a diameter of at least about 1.375 inches, and a cover having a retainer for securing the diaphragm to the valve base at the central portion of the valve base.

Abstract: A flat-folding mask includes a filter layer forming a rim. The filter layer has first and second side panels extending from the rim. A substantially centrally located front panel bridges the first and second side panels, the front panel being substantially flat. The filter layer further includes a fused portion that is seamless and spaced from the rim. Triangular pleats may add support to the side walls and increase the effective filtration area of the mask.