Abstract: Compounds that inhibit protein kinases such as Aurora-kinases and the VEGFR and PDGFR families of kinases, with an improved safety profile due to low CYP3A4 inhibition, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.

Abstract: Systems and methods are disclosed for allowing a recipient of an electronic message to verify the authenticity of the electronic message. A code can be included in the electronic message. The code can represent, or be associated with, an attribute of the electronic message. The recipient can navigate independently of the electronic message to a website familiar to the recipient and enter the code. In response, one or more attributes can be displayed to the recipient. The attributes are usable to verify the electronic message.

Abstract: Compounds having the formula: are useful for inhibiting protein kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A1, A2, A3, A4, X and Y are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as aurora and KDR.

Abstract: A steering system for a water vehicle includes a housing having a substantially cylindrical member, at least one case member extending through the substantially cylindrical member, a column shaft extending through the pair of case members, including at least one elongated hole disposed on opposed side of the column shaft, and being arranged to move relative to the pair of case members and the housing in an axial direction of the column shaft, and a telescoping mechanism partially disposed in the column shaft. One of the pair of case members includes a plurality of detents provided on an inner surface thereof. The telescoping mechanism includes at least one elongated hole disposed at one end portion of the telescoping mechanism, a locking pin extending through the at least one elongated hole in the telescoping mechanism and the at least one elongated hole in the column shaft, and a lever disposed at an opposite end portion from the one end portion of the telescoping mechanism.

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract: Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract: A duct structure for a watercraft includes a flexible tube for providing an air intake for the watercraft and a flexible member for being disposed on an inner perimeter of a hole in a hull of the watercraft for holding the flexible tube. A convex portion of the flexible tube engages at least one concave portion of the flexible member around substantially the entire circumference of the flexible member, allowing for easy insertion and removal of the flexible tube from the flexible member.

Abstract: A watercraft includes a lower hull, a deck having an opening provided therein, a storage plate, and a storage space defined by a portion of the lower hull, a portion of the deck, and the storage plate. The storage plate has at least one folding line such that the storage plate can be inserted through the opening in the deck when the storage plate is folded along the at least one folding line, and such that the storage plate can be unfolded and installed inside of the hull to define the storage space.

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract: Compounds having the formula are useful for inhibiting protein tyrosine kinases. The present invention also discloses methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds.

Abstract: Compositions comprising an elastomer and a carbon black are disclosed, which may be used to form articles having higher gloss and/or jetness than articles formed using an industry standard carbon black such as N650. The carbon blacks may be characterized by an I2No. of from about 80 to about 400 mg/g, a DBP value of from about 50 to about 175 cc/100 g, a tint value of from about 100 to about 175% ITRB, a N2SA value of from about 80 to about 450 m2/g, and/or a CTAB value of from about 80 to about 300 m2/g. Also described are articles made from the composition, and processes for making the article.

Abstract: Growth of keratinocytes is provided by subjecting a basal medium, insulin, pituitary compound and keratinocytes to cell growth conditions. Cell growth can be provided in the absence of exogenous epidermal growth factor. A conditioned medium results after the keratinocytes are subjected to cell growth conditions, treated keratinocytes are provided, and the treated keratinocytes are subjected to cell growth conditions in a basal medium. The conditioned medium contains autocrine factor. The conditioned medium then is contacted with further keratinocytes to provide a cell growth mixture. The cell growth mixture is subjected to incubation in order to provide replicative DNA synthesis and hence cell proliferation. Cells so provided can be used for dermatological research, toxicological testing and skin grafts.