Abstract: The present application is directed to compositions and methods for establishing organoid cultures from cryogenically preserved tissue (e.g., human biopsy tissue), and related methods of use with such established organoid cultures.

Abstract: The invention relates to a tube for a surgical microscope. The tube has a base part, an intermediate part, which is pivotable about a rotational axis on the base part, and an ocular part which is pivotable about a rotational axis on the intermediate part. The imaging beam path is guided through the base part, the intermediate part and the pivotable ocular part. The tube has a tube lens system which transfers a parallel imaging beam paths into an intermediate image. The parallel imaging beam path enters via an opening in a connecting piece of the base part. The tube has a first displaceable mirror element which can be moved about the rotational axis on the base part. The tube lens system is a telesystem which has a lens unit having positive refractive power and a lens unit having negative refractive power.

Abstract: A tube of a surgical microscope has a base part, intermediate part pivotable about a rotational axis on the base part, and an ocular part pivotable about a rotational axis on the intermediate part. An imaging beam path passes through the base part, intermediate part and ocular part. The tube has a tube lens system which transfers a parallel imaging beam path into an intermediate image. The parallel imaging beam path enters via an opening in a connecting piece of the base part. The tube has a first mirror movable about the rotational axis on the base part and a further mirror movable on the intermediate part about the rotational axis. The first mirror directs the imaging beam path to the further mirror. The first mirror and further mirror are mounted in the imaging beam path between a lens unit having positive refractive power and a lens unit having negative refractive power.

Abstract: A tube of a surgical microscope has a base part, intermediate part pivotable about a rotational axis on the base part, and an ocular part pivotable about a rotational axis on the intermediate part. The imaging beam path is guided through the base part, intermediate part and pivotable ocular part. The tube has a tube lens system which transfers a parallel imaging beam path into an intermediate image. The parallel imaging beam path enters via an opening in a connecting piece of the base part. The tube has a first displaceable mirror element movable about the rotational axis on the base part. The tube has a further displaceable mirror element movable on the intermediate part about the rotational axis. The first mirror element directs the imaging beam path to the further mirror element. The first mirror element and further mirror element are mounted in the imaging beam path between a lens unit having positive refractive power and a lens unit having negative refractive power.

Abstract: A tube of a surgical microscope has a base part, intermediate part, pivotable about a rotational axis on the base part, and an ocular part pivotable about a rotational axis on the intermediate part. The imaging beam path is guided through the base part, intermediate part and pivotable ocular part. The tube has a tube lens system which transfers a parallel imaging beam path into an intermediate image. The parallel imaging beam path enters via an opening in a connecting piece of the base part. The tube has a first displaceable mirror element movable about the rotational axis on the base part. The tube has a further displaceable mirror element movable on the intermediate part about the rotational axis. The first mirror element directs the imaging beam path to the further mirror element. The first mirror element and further mirror element are mounted in the imaging beam path between a lens unit having positive refractive power and a lens unit having negative refractive power.