Abstract: Provided herein are RET kinase inhibitors according to the formula: pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, and methods for their use in the treatment of diseases that can be treated with a RET kinase inhibitor, including RET-associated diseases and disorders. A, R1, n, X1, X2, X3, X4, and R2 have the meanings given in the specification.

Abstract: This disclosure addresses the problem of preventing sediment laden water (“sediment slurry”) resulting from hydraulic collection of nodules from the seabed from entering the riser and lift system that carries the nodules to the surface as a slurry. An example includes collecting nodules from the seabed by hydraulic suction, separating the nodules utilizing an inverse hydrocyclone.

Abstract: A method for producing a perovskite material photovoltaic device, the method comprising: depositing a layer comprising a fullerene or fullerene derivative on a perovskite material; depositing a cross-linking agent on the perovskite material or the layer comprising the fullerene or fullerene derivative, wherein the cross-linking agent comprises a silane, wherein the silane is a halosilyalkane; and depositing one or more polymers on the perovskite material or the layer comprising the fullerene or fullerene derivative.

Abstract: Systems and methods for calibrating an adaptive illumination system of an imager are presented. An example method includes causing the system to enter a calibration mode and providing a calibration illumination level from an illumination source to an environment. An imager captures one or more images of the environment. A processor determines, from the one or more images, a first illumination intensity to provide during an object detect mode operation of the system. The first illumination intensity has an illumination sufficient for detecting a presence of an object in the environment during the object detect mode. The processor stores the first illumination intensity in a memory, and configures the illumination source to provide illumination at the first illumination intensity while the adaptive illumination system is in the object detect mode, and (ii) provide illumination at a second illumination intensity while the adaptive illumination system is in a scanning mode.

Abstract: A protective clothing equipment is provided that is comfortable, stabilizing, and compatible with varying types of surfaces. One embodiment of the protective clothing equipment includes a shell, padding disposed in front of the knee of the wearer, the padding including a non-uniform stiffness.

Abstract: A light controlled semiconductor switch (LCSS), method of making, and method of using are provided. In embodiments, a vertical LCSS includes: a semiconductor body including a photoactive layer of gallium nitride (GaN) doped with carbon; a first electrode in contact with a first surface of the semiconductor body, the first electrode defining an area through which light energy from at least one light source can impinge on the first surface; and a second electrode in contact with a second surface of the semiconductor body opposed to the first surface, wherein the vertical LCSS is configured to switch from a non-conductive off-state to a conductive on-state when the light energy impinging on the semiconductor body is sufficient to raise electrons within the photoactive layer into a conduction band of the photoactive layer.

Abstract: A digital dispense system and methods for preparing samples for analysis. The digital dispense system includes a fluid droplet ejection system housed in a housing unit. The fluid droplet ejection system contains a fluid droplet ejection head and fluid cartridge containing one or more fluids to be dispensed. A cartridge translation mechanism is provided for moving the fluid droplet ejection head and fluid cartridge back and forth over a sample holder in an x direction. A sample tray translation mechanism moves a sample tray back and forth beneath the fluid droplet ejection head and fluid cartridge in a y direction orthogonal to the x direction.

Abstract: A pharmaceutical drug delivery device and method of preventing drying out and drooling of an ejection head for the drug delivery device. The device includes a drug delivery device body; a fluid outlet nozzle attached to the drug delivery device body; and a fluid jet ejection cartridge containing a liquid pharmaceutical drug disposed in the drug delivery device body. A fluid ejection head is attached to the fluid jet ejection cartridge and the fluid ejection head is in fluid flow communication with the fluid outlet nozzle. An elongate, serpentine air flow path is provided between and outer surface of the fluid jet ejection cartridge and an inner surface of the fluid outlet nozzle. The elongate, serpentine air flow path provides a reduced pressure differential adjacent to a surface of the fluid ejection head upon use of the drug delivery device and provides a humidification zone.

Abstract: A system for controlling a plurality of actuators is disclosed. The system includes at least one device for operating the plurality of actuators, at least one processor in communication with the device, and a memory coupled the processor. The memory stores data comprising program code that, when executed by the at least one processor, causes the system to receive as input a profile number indicating a specific test being performed by the system and a profile row indicating a load exerted by the plurality of actuators. The system is further caused to select a predetermined gain output based on the profile number and the profile row from a gain array. The gain array is a matrix containing a plurality of gain values, and the predetermined gain output is selected based on the profile number and the profile row. The system is further caused to determine a control value.

Abstract: A system for analyzing one or more operations associated with a component of a machine is disclosed. The system includes a data warehouse for storing data associated with the machine. The system includes a data extraction module, which extracts the data from the data warehouse and receives a customer input. The data extraction module generates an input parameter based on the data from the data warehouse and the customer input. The system includes a failure injection module for storing information of the one or more failures associated with the component of the machine. The system also includes a machine model, which is in communication with the data extraction module and the failure injection module. The machine model derives an output parameter associated with the one or more operations of the component of the machine, based on the input parameter and the information of the one or more failures.

Abstract: In order to reduce drivetrain component wear and tear, a machine monitors for an impending downshift and automatically slows the machine to a speed that keeps engine rpm below a target engine rpm before the downshift is completed. A controller in the machine determines the current speed of the machine and then slows the machine to a new speed associated with the target rpm in the new gear. The controller may simply apply the brakes to slow the machine to the new speed independently of the process of changing gears or may actively delay the gear change until the new speed is achieved.

Abstract: A system for controlling a plurality of actuators is disclosed. The system includes at least one device for operating the plurality of actuators, at least one processor in communication with the device, and a memory coupled the processor. The memory stores data comprising program code that, when executed by the at least one processor, causes the system to receive as input a profile number indicating a specific test being performed by the system and a profile row indicating a load exerted by the plurality of actuators. The system is further caused to select a predetermined gain output based on the profile number and the profile row from a gain array. The gain array is a matrix containing a plurality of gain values, and the predetermined gain output is selected based on the profile number and the profile row. The system is further caused to determine a control value.

Abstract: A system for analyzing one or more operations associated with a component of a machine is disclosed. The system includes a data warehouse for storing data associated with the machine. The system includes a data extraction module, which extracts the data from the data warehouse and receives a customer input. The data extraction module generates an input parameter based on the data from the data warehouse and the customer input. The system includes a failure injection module for storing information of the one or more failures associated with the component of the machine. The system also includes a machine model, which is in communication with the data extraction module and the failure injection module. The machine model derives an output parameter associated with the one or more operations of the component of the machine, based on the input parameter and the information of the one or more failures.

Abstract: An approach is provided for identifying, from a moving vehicle, an object proximate to a direction of the moving vehicle. The identified object is illuminated with a colored laser light with the colored laser light emanating from a laser included in the vehicle.

Abstract: In order to reduce drivetrain component wear and tear, a machine monitors for an impending downshift and automatically slows the machine to a speed that keeps engine rpm below a target engine rpm before the downshift is completed. A controller in the machine determines the current speed of the machine and then slows the machine to a new speed associated with the target rpm in the new gear. The controller may simply apply the brakes to slow the machine to the new speed independently of the process of changing gears or may actively delay the gear change until the new speed is achieved.

Abstract: A flowmeter includes a process sensor assembly providing a sensor signal and a filter stage comprising a low pass filter and a high pass filter and providing a filtered signal from the sensor signal. A processor determines that a filtered signal is indicative of a low flow condition for a first fluid, alters at least one parameter of the low pass filter and at least one parameter of the high pass filter in response to the low flow condition such that the filter stage provides a new filtered signal, determines that the new filtered signal is not indicative of a low flow condition for a second fluid and generates an alarm in response to the new filtered signal not being indicative of a low flow condition for the second fluid.

Abstract: A flowmeter includes a process sensor assembly providing a sensor signal and a filter stage comprising a low pass filter and a high pass filter and providing a filtered signal from the sensor signal. A processor determines that a filtered signal is indicative of a low flow condition for a first fluid, alters at least one parameter of the low pass filter and at least one parameter of the high pass filter in response to the low flow condition such that the filter stage provides a new filtered signal, determines that the new filtered signal is not indicative of a low flow condition for a second fluid and generates an alarm in response to the new filtered signal not being indicative of a low flow condition for the second fluid.

Abstract: A portable light includes: a cylindrical housing having a longitudinal axis and receiving a bezel and a lamp for projecting a light radially away from the longitudinal axis; and a cradle assembly including a clamp for receiving the cylindrical housing, wherein the clamp includes a plurality of features for engaging selected ones of corresponding features on the cylindrical housing to secure the cylindrical housing at a selected rotational position about its longitudinal axis with regard to the cradle assembly.

Abstract: A flexible cargo bed tie-down system allows the user to easily change, adjust, customize, and adapt his or her vehicle to specific needs at any given moment, and interfaces with the rest of the vehicle in an optimum manner from a functional, structural, and aesthetic standpoint. One embodiment of the invention provides a vehicle having a side wall construction enclosing a cargo bed at a side of the cargo bed. The side wall construction includes an outer portion which runs generally vertically at an outer portion of the vehicle, and a top portion which runs generally horizontally from the outer portion toward a longitudinal center of the vehicle. A tie-down rail is mounted adjacent to the top portion such that a part of the top portion overhangs at least a portion of the tie-down rail. The tie-down rail is configured to accept a tie-down fitting and includes a slotted opening generally aligned with an interior edge of the top portion.

Abstract: A self-contained material handler for lifting and manually moving a load includes a deck portion configured to be positioned beneath a load and a plurality of air casters secured on a bottom surface of the deck portion. An air source is secured to the deck portion, and the air source is in selective fluid communication with the plurality of air casters. A power source is secured to the deck portion for supplying power to the air source.