Abstract: A coupling assembly for a turbine engine. The coupling assembly includes a cold side component, a hot side component, and a fastening mechanism. The cold side component and the hot side component together at least partially form a combustion chamber. The fastening mechanism couples the hot side component to the cold side component. The fastening mechanism includes a stud disposed through the cold side component and a cap positioned on the stud. The cap defines a hollow interior and includes one or more first cap cooling holes. The one or more first cap cooling holes operably direct cooling air into the hollow interior such that the hollow interior provides a cushion of air between the combustion chamber and the stud.

Abstract: A building structure comprising a first film and a second film. The first film and the second film are each impregnated with L-Dopa. The building structure further includes regolith bulk material between the first film and the second film.

Abstract: This disclosure relates to JAK1 pathway inhibitors and their use in treating vitiligo.

Abstract: An aerosol delivery device having a detachable power source is provided. A control body may be coupleable with a cartridge to form an aerosol delivery device. The cartridge may contain an aerosol precursor composition and be equipped with a heating element configured to activate and vaporize components of the aerosol precursor composition. The control body may comprise a housing and a power source detachably coupled to an outer surface of the housing. A control component may be contained within the housing and configured to operate in an active mode in which the control body is coupled with the cartridge. The control component in the active mode may be configured to direct power from the power source to the heating element to activate and vaporize components of the aerosol precursor composition.

Abstract: Pump assemblies and systems are provided. For example, a pump assembly comprises a pump head, a bezel surrounding an outer perimeter of the pump head, a motor, and tubing. The bezel comprises a bezel upper side, a bezel lower side opposite the bezel upper side, a bezel inlet side extending from the bezel upper side to the bezel lower side, and a bezel outlet side opposite the bezel inlet side and extending from the bezel upper side to the bezel lower side. The bezel defines an inlet channel on the bezel inlet side and an outlet channel on the bezel outlet side, each of the inlet channel and the outlet channel guiding the tubing into the pump head. An exemplary pump system comprises a plurality of pump assemblies that each supply a fluid to a cooling circuit and a base for supporting the plurality of pump assemblies.

Abstract: Pump heads for peristaltic pump assemblies are provided. For example, a pump head for a peristaltic pump comprises an occlusion bed, a rotor guide, a rotor assembly positioned between the occlusion bed and the rotor guide, and a pathway for tubing. The pathway comprises an inlet portion, an outlet portion, and a connecting portion that connects the inlet and outlet portions. The inlet portion is defined between the occlusion bed and the rotor guide, the outlet portion is defined between the occlusion bed and the rotor guide, and the connecting portion is defined between the occlusion bed and the rotor assembly. Further, the occlusion bed is movable with respect to the rotor guide and the rotor assembly. In exemplary embodiments, the pump head urges fluid flow through the tubing to supply a cooling fluid to a medical probe assembly for delivering energy to a patient's body.

Abstract: A pump system for pumping a coolant fluid for cooled radiofrequency ablation treatment includes a housing having a front, a back, a right side, a left side, a top surface, and a bottom surface, and a plurality of peristaltic pump assemblies. The top surface of the housing includes a central channel between at least two of the peristaltic pump assemblies configured to drain fluid away from the front of the housing. A cooled radiofrequency ablation system additionally includes a pump system and a generator having mating surfaces such that the pump system can sit stably on top of the generator.

Abstract: A building structure comprising a first film and a second film. The first film and the second film are each impregnated with L-Dopa. The building structure further includes regolith bulk material between the first film and the second film.

Abstract: Pump assemblies and systems are provided. For example, a pump assembly comprises a pump head, a bezel surrounding an outer perimeter of the pump head, a motor, and tubing. The bezel comprises a bezel upper side, a bezel lower side opposite the bezel upper side, a bezel inlet side extending from the bezel upper side to the bezel lower side, and a bezel outlet side opposite the bezel inlet side and extending from the bezel upper side to the bezel lower side. The bezel defines an inlet channel on the bezel inlet side and an outlet channel on the bezel outlet side, each of the inlet channel and the outlet channel guiding the tubing into the pump head. An exemplary pump system comprises a plurality of pump assemblies that each supply a fluid to a cooling circuit and a base for supporting the plurality of pump assemblies.

Abstract: Pump heads for peristaltic pump assemblies are provided. For example, a pump head for a peristaltic pump comprises an occlusion bed, a rotor guide, a rotor assembly positioned between the occlusion bed and the rotor guide, and a pathway for tubing. The pathway comprises an inlet portion, an outlet portion, and a connecting portion that connects the inlet and outlet portions. The inlet portion is defined between the occlusion bed and the rotor guide, the outlet portion is defined between the occlusion bed and the rotor guide, and the connecting portion is defined between the occlusion bed and the rotor assembly. Further, the occlusion bed is movable with respect to the rotor guide and the rotor assembly. In exemplary embodiments, the pump head urges fluid flow through the tubing to supply a cooling fluid to a medical probe assembly for delivering energy to a patient's body.

Abstract: A pump system for pumping a coolant fluid for cooled radiofrequency ablation treatment includes a housing having a front, a back, a right side, a left side, a top surface, and a bottom surface, and a plurality of peristaltic pump assemblies. The top surface of the housing includes a central channel between at least two of the peristaltic pump assemblies configured to drain fluid away from the front of the housing. A cooled radiofrequency ablation system additionally includes a pump system and a generator having mating surfaces such that the pump system can sit stably on top of the generator.

Abstract: A hydrocarbon line sampler connected to a pipeline containing hydrocarbon fluid, the sampler including a draw mechanism and a sampling can. The sampler includes a detector for testing a quality attribute of the fluid. The detector passes a signal to a controller, the controller being preprogrammed with a set threshold of one or more quality thresholds. When a quality threshold is met, the controller can modify the sampling regimen for later storage or further on-site testing. The invention includes a method of drawing a sample, testing the sample, determining the quality of the sample, and modifying the sampling regimen as need, or otherwise setting an alarm, or taking action on the pipeline system.

Abstract: The present invention provides an enzymatic means for the biosynthetic production of caffeine. The present invention provides biosynthetic methods for production of caffeine comprising: providing guanine, a guanine deaminase, at least one methyl transferase, and a methyl donor; contacting the guanine with the gtheuanine deaminase to produce xanthine; contacting the xanthine with the methyl transferase and a methyl donor, under conditions wherein the xanthine is methylated, to produce a monomethylxanthine; contacting the monomethylxanthine with the methyl transferase and a methyl donor, under conditions wherein the monomethylxanthine is methylated, to produce a dimethylxanthine; and contacting the dimethylxanthine with the methyl transferase and a methyl donor, under conditions wherein the dimethylxanthine is methylated, to produce caffeine (i.e., 1,3,7-trimethylxanthine).

Abstract: A flow control regulator assembly having a regulator body with an inflow channel that couples an inlet of the regulator body to a flow rate port and an exit flow channel which couples the flow rate port to an outlet port of the regulator body. The minimal cross-sectional area of the exit flow channel is larger than the maximum cross-sectional area of the inflow channel.

Abstract: Provided herein are cell lines and assays that can be utilized to identify taste receptor modulators.

Abstract: Apparatus for flow prover precisely measures the volume and the flow rate of a fluid through a cylinder. The prover includes a piston within a cylinder supporting a shaft extending longitudinally through the cylinder, which cylinder receives and discharges the fluid by translation of the piston from the fluid receiving end to the fluid discharging end. Motive means draws the shaft and piston toward the fluid receiving end of the cylinder. Travel of the piston in the direction from the fluid receiving end to the fluid discharging end of the cylinder is sensed at discrete locations to provide an indication of the volume of fluid therebetween and the related flow rate. Each of a plurality of emitter/detector modules provides piston position sensing signals reflective of the volume and rate of fluid flowing through the cylinder. A switch bar rigidly and permanently fixes the position of the emitter/detector modules with respect to the piston and with respect to one another.

Abstract: It is an object of the present invention to provide a novel illumination system and methods that can be used on the outside of an automobile. The illumination system may preferably be displayed on the outside of a door panel of an automobile, but may also be displayed on any other exterior surface of an automobile. The illuminated design may employ fiber optic cables to illuminate the preferred design.

Abstract: Apparatus for flow prover precisely measures the volume and the flow rate of a fluid through a cylinder. The prover includes a piston within a cylinder supporting a shaft extending longitudinally through the cylinder, which cylinder receives and discharges the fluid by translation of the piston from the fluid receiving end to the fluid discharging end. Motive means draws the shaft and piston toward the fluid receiving end of the cylinder. Travel of the piston in the direction from the fluid receiving end to the fluid discharging end of the cylinder is sensed at discrete locations to provide an indication of the volume of fluid therebetween and the related flow rate. Each of a plurality of emitter/detector modules provides piston position sensing signals reflective of the volume and rate of fluid flowing through the cylinder. A switch bar rigidly and permanently fixes the position of the emitter/detector modules with respect to the piston and with respect to one another.

Abstract: The present invention provides methods for identifying compounds that selectively and specifically modulate RGS21 gene expression, RGS21 protein expression, and/or the interaction of RGS21 with G proteins in taste signal transduction. In particular, the present invention provides methods for identifying modulators of RGS21 activity for enhancing sweet taste, or other taste perception. Compositions comprising modulators of RGS21 activity for modulating taste signaling transduction are also provided.

Abstract: A GNSS-based contour guidance path selection system for guiding a piece of equipment through an operation, such as navigating a guide path, includes a processor programmed for locking onto a particular aspect of the operation, such as deviating from a pre-planned or original guidance pattern and locking the guidance system onto a new route guide path, while ignoring other guidance paths. The system gives a vehicle operator control over a guidance route without the need to re-plan a pre-planned route. The device corrects conflicting signal issues arising when new swaths result in the guidance system receiving conflicting directions of guidance where the new swaths cross predefined swaths. An operator can either manually, or with an autosteer subsystem automatically, maintain a new contour guidance pattern, even while crossing predefined guidance paths that would otherwise divert the vehicle.