Abstract: Disclosed is an important therapeutic strategy of targeting MNK to block eIF4E phosphorylation for the treatment of persistent inflammatory pain in later life. In one embodiment, a therapeutic drug that targets MNK and inhibits MNK is selected in order to block eIF4E phosphorylation and the therapeutic drug is administered to the subject with sufficient dosage to block eIF4E phosphorylation. The treatment is suitable for aged subjects experiencing inflammatory pain such as age-associated inflammation, age-associated low-grade inflammation, CFA-induced acute inflammation, spontaneous pain, mechanical hypersensitivity or thermal hypersensitivity.

Abstract: A dual mode visible and infrared lighthead (100) for use as a landing light or searchlight. The dual mode lighthead incorporates a modular design wherein at least one visible light source (200) and at least one infrared diode (302) are mounted into the rear sector (128) of a housing (102). Visible or infrared light is emitted out of the front sector (122) of the housing (102). Lenses (308) are installed onto the front sector (122) of housing (102) and sealed to protect the interior of the lighthead (100) from the elements.

Abstract: A dual mode visible and infrared lighthead (100) for use as a landing light or searchlight. The dual mode lighthead incorporates a modular design wherein at least one visible light source (200) and at least one infrared diode (302) are mounted into the rear sector (128) of a housing (102). Visible or infrared light is emitted out of the front sector (122) of the housing (102). Lenses (308) are installed onto the front sector (122) of housing (102) and sealed to protect the interior of the lighthead (100) from the elements.