Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.

Abstract: A method and apparatus for assessing performance in operating an aircraft. Information for assessing a performance of a group of operations performed by a number of crew members of the aircraft is displayed on a display system during operation of the aircraft by the number of crew members for which the group of operations is assessed. User input assessing the performance of the group of operations by the number of crew members is received through an input system. The user input is stored. A report on the performance of the group of operations performed by the number of crew members using the user input is generated.

Abstract: Sample processing methods that utilize a graphitised carbon matrix are useful for determining the relative amounts polyhalogenated biphenyls (PHBs), polyhalogenated dibenzofurans (PHDFs), and polyhalogenated dibenzo-p-dioxins (PHDDs) in a mixture of polyhalogenated diaromatic hydrocarbons (PHDHs). The methods are particularly useful when used in conjunction with cell-based assays for determining the toxicity of PHDH compounds.

Abstract: Sample processing methods that utilize a graphitised carbon matrix are useful for determining the relative amounts polyhalogenated biphenyis (PHBs), polyhalogenated dibenzofurans (PHDFs), and polyhalogenated dibenzo-p-dioxins (PHDDs) in a mixture of polyhalogenated diaromatic hydrocarbons (PHDHs). The methods are particularly useful when used in conjunction with cell-based assays for determining the toxicity of PHDH compounds.

Abstract: A process for the extraction and purification of TCDD (2,3,7,8-Tetrachlorodibenzo-p-dioxin) from a sample matrix. The process of the present invention overcomes a problem of prior art processes for extracting TCDD, by providing for chemical destruction of potentially interfering components in a sample matrix making the steam distillation of TCDD possible. A typical sample matrix comprises blood serum.