Patents by Inventor Michael D. Culler

Michael D. Culler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Somatostatin-dopamine chimeric analogs
    Patent number: 8324386
    Abstract: Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is: 6-n-propyl-8?-ergolinglmethylthioacetyl-D-Phe-c(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH2.
    Type: Grant
    Filed: October 7, 2009
    Date of Patent: December 4, 2012
    Assignee: IPSEN Pharma S.A.S.
    Inventors: Michael D. Culler, Zheng Xin Dong, Sun H. Kim, Jacques-Pierre Moreau
  • Somatostatin-dopamine chimeric analogs
    Patent number: 8178651
    Abstract: Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is: 6-n-propyl-8?-ergolinglmethylthioacetyl-D-Phe-c(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH2.
    Type: Grant
    Filed: June 22, 2009
    Date of Patent: May 15, 2012
    Assignee: IPSEN Pharma, S.A.S.
    Inventors: Michael D. Culler, Zheng Xin Dong, Sun H. Kim, Jacques-Pierre Moreau
  • Somatostatin-Dopamine Chimeric analogs
    Publication number: 20100179304
    Abstract: Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo.
    Type: Application
    Filed: October 7, 2009
    Publication date: July 15, 2010
    Inventors: Michael D. Culler, Zheng Xin Dong, Sun H. Kim, Jacques-Pierre Moreau
  • Somatostatin-dopamine chimeric analogs
    Publication number: 20090275501
    Abstract: Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo.
    Type: Application
    Filed: June 22, 2009
    Publication date: November 5, 2009
    Inventors: Michael D. Culler, Zheng Xin Dong, Sun H. Kim, Jacques-Pierre Moreau
  • Somatostatin-dopamine chimeric analogs
    Patent number: 7579435
    Abstract: Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo. An example is: 6-n-propyl-8?-ergolinglmethylthioacetyl-D-Phe-c-(Cys-Tyr-D-Trp-Lys-Abu-Cys)-Thr-NH2.
    Type: Grant
    Filed: June 7, 2002
    Date of Patent: August 25, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Michael D. Culler, Zheng Xin Dong, Sun H. Kim, Jacques-Pierre Moreau
  • Somatostatin-dopamine chimeric analogs
    Patent number: 7572883
    Abstract: Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo.
    Type: Grant
    Filed: May 15, 2006
    Date of Patent: August 11, 2009
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Michael D. Culler, Zheng Xin Dong, Sun H. Kim, Jacques-Pierre Moreau
  • Method of inhibiting fibrosis with a somatostatin agonist
    Patent number: 7238666
    Abstract: The present invention relates to a method of inhibiting fibrosis in a patient. The method comprises administering a therapeutically effective amount of a somatostatin, a somatostatin agonist or apharmaceutically acceptable salt thereof to said patent.
    Type: Grant
    Filed: September 7, 2004
    Date of Patent: July 3, 2007
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S
    Inventors: Michael D. Culler, Philip G. Kasprzyk
  • Somatostatin analog and uses thereof
    Patent number: 7094753
    Abstract: Claimed is a somatostatin agonist according to formula (I), D-Phe-c(Cys-Tyr(I)-D-Trp-Lys-Val-Cys)-Thr-NH2, ??(I) or a pharmaceutically acceptable salt thereof, and uses thereof.
    Type: Grant
    Filed: November 21, 2002
    Date of Patent: August 22, 2006
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, SAS
    Inventors: Thomas D. Gordon, Barry A. Morgan, Michael D. Culler
  • Somatostatin-dopamine chimeric analogs
    Publication number: 20040209798
    Abstract: Disclosed is a series of somatostatin-dopamine chimeric analogs which retain both somatostatin and dopamine activity in vivo.
    Type: Application
    Filed: May 17, 2004
    Publication date: October 21, 2004
    Inventors: Michael D Culler, Zheng Xin Dong, Sun H Kim, Jacques-Pierre Moreau
  • Method of inhibiting fibrosis with a somatostatin agonist
    Patent number: 6787521
    Abstract: The present invention relates to a method of inhibiting fibrosis in a patient. The method comprises administering a therapeutically effective amount of a somatostatin, a somatostatin agonist or a pharmaceutically acceptable salt thereof to said patent.
    Type: Grant
    Filed: January 16, 2001
    Date of Patent: September 7, 2004
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, S.A.S.
    Inventors: Michael D. Culler, Philip G. Kasprzyk
  • Somatostatin analog and uses thereof
    Publication number: 20030153494
    Abstract: Claimed is a somatostatin agonist according to formula (I),
    Type: Application
    Filed: November 21, 2002
    Publication date: August 14, 2003
    Inventors: Thomas D. Gordon, Barry A. Morgan, Michael D. Culler
  • Prolonging survival of transplanted pancreatic cells
    Patent number: 6342479
    Abstract: A method of prolonging the survival of pancreatic cells transplanted in a patient. The method includes the step of administering a therapeutically effective amount of somatostatin or a somatostatin agonist to the patient.
    Type: Grant
    Filed: March 1, 1999
    Date of Patent: January 29, 2002
    Assignee: Societe de Counseils de Recherches et d'Applications Scientifiques, SAS
    Inventor: Michael D. Culler
  • Method of inhibiting fibrosis with a somatostatin agonist
    Publication number: 20010011072
    Abstract: The present invention relates to a method of inhibiting fibrosis in a patient. The method comprises administering a therapeutically effective amount of a somatostatin, a somatostatin agonist or a pharmaceutically acceptable salt thereof to said patent.
    Type: Application
    Filed: January 16, 2001
    Publication date: August 2, 2001
    Applicant: Biomeasure, Incorporated
    Inventors: Michael D. Culler, Philip G. Kasprzyk
  • Method of inhibiting fibrosis with a somatostatin agonist
    Patent number: 6268342
    Abstract: The present invention relates to a method of inhibiting fibrosis in a patient. The method comprises administering a therapeutically effective amount of a somatostatin, a somatostatin agonist or apharmaceutically acceptable salt thereof to said patient.
    Type: Grant
    Filed: May 10, 1999
    Date of Patent: July 31, 2001
    Assignee: Biomeasure Incorporated
    Inventors: Michael D. Culler, Philip G. Kasprzyk
  • Method of treating hyperprolactinemia and prolactinomas
    Patent number: 5972893
    Abstract: A method of treating hyperprolactinemia in an animal, including a human, administers one or more somatostatin type-5 receptor agonist(s) to, for example, lower abnormally high levels of prolactin in the blood of the animal. A method of treating a subject, including a human, afflicted by a prolactinoma, administers one or more type-5 receptor selective agonist(s) to, for example, lower prolactin secretion and/or decrease tumor size in the subject.
    Type: Grant
    Filed: May 6, 1997
    Date of Patent: October 26, 1999
    Assignee: Cedars-Sinai Medical Center
    Inventors: Shlomo Melmed, Ilan Shimon, Michael D. Culler
  • Prolonging survival of transplanted pancreatic cells
    Patent number: 5686418
    Abstract: A method of prolonging the survival of pancreatic cells transplanted in a patient. The method includes the step of administering a therapeutically effective amount of a somatostatin or a somatostatin agonist to the patient.
    Type: Grant
    Filed: April 8, 1996
    Date of Patent: November 11, 1997
    Assignee: Biomeasure Incorporated
    Inventor: Michael D. Culler
  • Method of measuring thymopoietin proteins in plasma and serum including acidification of the plasma and serum
    Patent number: 5593842
    Abstract: Method for accurately measuring thymopoietin (TP) in human serum or plasma by dissociating TP from protein complexes, releasing bound TP in a unbound form, extracting TP, preparing it for assay, and measuring TP levels in a suitable assay.
    Type: Grant
    Filed: September 20, 1994
    Date of Patent: January 14, 1997
    Assignee: Gideon Goldstein
    Inventors: Gideon Goldstein, Michael D. Culler
  • Method for the diagnosis of depression based on monitoring blood levels of arginine vasopressin and/or thymopoietin
    Patent number: 5591588
    Abstract: The invention provides a novel means of diagnosing, or confirming a diagnosis of, affective disorders, such as depression, based on the blood levels of arginine vasopressin and thymopoietin, either alone or in combination.
    Type: Grant
    Filed: September 20, 1994
    Date of Patent: January 7, 1997
    Assignee: Gideon Goldstein
    Inventors: Gideon Goldstein, Michael D. Culler
  • Recombinant human thymopoietin proteins and uses therefor
    Patent number: 5472856
    Abstract: The present invention provides novel nucleotide and amino acid sequences for human thymopoietin .alpha., .beta., and .gamma., methods of recombinantly expressing same, and diagnostic and therapeutic uses thereof.
    Type: Grant
    Filed: December 21, 1993
    Date of Patent: December 5, 1995
    Assignee: Immunobiology Research Institute, Inc.
    Inventors: Crafford A. Harris, Gideon Goldstein, John J. Siekierka, Mary A. Talle, Ponniah Shenbagamurthi, Michael D. Culler, Diane R. Setcavage
  • Synthetic peptides
    Patent number: 4562175
    Abstract: A synthetic peptide growth hormone releasing factor having substantially the following amino acid sequence: ##STR1## methods of inducing growth in an animal and growth inducing pharmaceutical compositions, including animal feed compositions, are disclosed.
    Type: Grant
    Filed: February 3, 1984
    Date of Patent: December 31, 1985
    Inventors: Ding Chang, Akira Arimura, Michael D. Culler, Jaw-Kang Chang