Abstract: A manual pallet exchange system for exchanging a pallet on a work table of a horizontal machining center with another pallet from a storage rack or an optional set-up station. The system comprises a pallet shuttle cart which travels along a guideway that is positioned adjacent to the storage rack, the set-up station and the horizontal machining center. Receiving devices are provided on the horizontal machining center, the shuttle cart, the set-up station and each pallet storage location on the storage rack for receiving and supporting the pallet. A mechanically activated locking device provides for safely securing the pallet to the receiving devices of the storage rack, the set-up station and the shuttle cart.