Abstract: An implantable device includes an adjustable spacer and at least one anchor. The adjustable spacer is configured to be positioned between native heart valve leaflets to reduce regurgitation therebetween. An clastic or stretchable cover is part of or disposed over the adjustable spacer.

Abstract: An implantable device includes an adjustable spacer and at least one anchor. The adjustable spacer is configured to be positioned between native heart valve leaflets to reduce regurgitation therebetween. The adjustable spacer can comprise a first side and a second side opposite the first side. Each side can be adjustable between a first width and a second width. Each side can be independently moved between the first width and the second width. The adjustable spacer can be made from a sponge material.

Abstract: The present disclosure relates to methods and intermediates for the synthesis of certain compounds that inhibit MCL1, for use in the treatment of cancers.

Abstract: Methods, computer program products and systems are described for online-content management. Multiple online content items authored by multiple authors are received at one or more first computers for online publication. For each online content item, a reputation score is determined for the author of the online content item. The reputation score is based at least in part on one or more reviews of the online content item provided by one or more reviewers other than the author. In response to a query for online content received from a second computer, a set of search results is generated that includes an online content item from the multiple online content items. A ranking of the online content item in the set is determined based at least in part on the reputation score of the author.

Abstract: Methods, computer program products and systems are described for online-content management. Multiple online content items authored by multiple authors are received at one or more first computers for online publication. For each online content item, a reputation score is determined for the author of the online content item. The reputation score is based at least in part on one or more reviews of the online content item provided by one or more reviewers other than the author. In response to a query for online content received from a second computer, a set of search results is generated that includes an online content item from the multiple online content items. A ranking of the online content item in the set is determined based at least in part on the reputation score of the author.

Abstract: A composite nozzle strip for hydroentangling of a fibrous mass is provided to lower nozzle erosion potential and increase operational efficiency. The composite nozzle strip comprises a substrate comprising a material of a first hardness having at least one aperture and at least one orifice element comprising a material of a second hardness greater than the first hardness and further defining an aperture of a second diameter less than the first diameter. The at least one orifice element is affixed to the substrate so that the aperture in the orifice element is aligned with the at least one aperture in the substrate for creation of a constricted water jet when subjected to pressurized water.

Abstract: A client system stores messages and sends the messages to a server system. The messages are included in a request formatted according to a protocol that can traverse a firewall. Then the client system waits for a response from the server system. The response will also be formatted according to the protocol that can traverse the firewall. The response will include an indication of which messages the server system received from the client system in the last request. If a certain number of messages accumulate at the client system, or a certain amount of time passes before the response is received, the client system will send a second request. The server system also stores messages and sends the messages to the client system. The server system waits for a first request and a second request from the client system. If the first request has been received and a particular number of messages have accumulated at the server system, then the server system will send a response corresponding to the first request.

Abstract: In a network, a media coordination system provides secure multimedia communication channels in a collaborative network environment. The media coordination system provides automatic encryption, dynamic interconnection of streams of data, and user interface elements that provide users with control over the ultimate destination of their audio and video data. The infrastructure of the system includes a plurality of client workstations that are connected to a central server using point-to-point network connections. The central server maintains a persistent virtual world of network places with objects located therein. Streams of audio and video data are coordinated between client workstations operating in the persistent virtual world by a key manager object using channels, transmitters, and receivers. The client workstations multicast their audio and video data over the network to defined recipients after receiving a multicast address and an encryption key for a specific multicast channel.

Abstract: A method of use of real time machine control software integrating both event based mode and task based components. In particular, a collection of constructs have been created that allow machine control applications to be expressed in event based terms and the event based constructs to be seamlessly integrated with task based constructs. The method includes the use of response time specifications, in particular in conjunction with ReactiveTask and Task constructs. The method also includes the use of Register, ReferenceClock, and SchedulerLock constructs.

Abstract: A partial evaluator, or pre-compiler, for a computer program enables a user to provide, at suitable places within a program, language constructs which cause certain expressions within the program to be evaluated at runtime or at partial evaluation time. These language constructs can be used to shorten runtime, such as by avoiding unnecessary duplication of code at runtime.

Abstract: In a network, a media coordination system provides secure multimedia communication channels in a collaborative network environment. The media coordination system provides automatic encryption, dynamic interconnection of streams of data, and user interface elements that provide users with control over the ultimate destination of their audio and video data. The infrastructure of the system includes a plurality of client workstations that are connected to a central server using point-to-point network connections. The central server maintains a persistent virtual world of network places with objects located therein. Streams of audio and video data are coordinated between client workstations operating in the persistent virtual world by a key manager object using channels, transmitters, and receivers. The client workstations multicast their audio and video data over the network to defined recipients after receiving a multicast address and an encryption key for a specific multicast channel.

Abstract: A method of use of real time machine control software integrating both event based mode and task based components. In particular, a collection of constructs have been created that allow machine control applications to be expressed in event based terms and the event based constructs to be seamlessly integrated with task based constructs. The method includes the use of response time specifications, in particular in conjunction with ReactiveTask and Task constructs. The method also includes the use of Register, ReferenceClock, and SchedulerLock constructs.

Abstract: In a network, a media coordination system provides secure multimedia communication channels in a collaborative network environment. The media coordination system provides automatic encryption, dynamic interconnection of streams of data, and user interface elements that provide users with control over the ultimate destination of their audio and video data. The infrastructure of the system includes a plurality of client workstations that are connected to a central server using point-to-point network connections. The central server maintains a persistent virtual world of network places with objects located therein. Streams of audio and video data are coordinated between client workstations operating in the persistent virtual world by a key manager object using channels, transmitters, and receivers. The client workstations multicast their audio and video data over the network to defined recipients after receiving a multicast address and an encryption key for a specific multicast channel.

Abstract: A method of use of real time machine control software integrating both event based mode and task based components. In particular, a collection of constructs have been created that allow machine control applications to be expressed in event based terms and the event based constructs to be seamlessly integrated with task based constructs. The method includes the use of response time specifications, in particular in conjunction with ReactiveTask and Task constructs. The method also includes the use of Register, ReferenceClock, and SchedulerLock constructs.

Abstract: In a network, a media coordination system provides secure multimedia communication channels in a collaborative network environment. The media coordination system provides automatic encryption, dynamic interconnection of streams of data, and user interface elements that provide users with control over the ultimate destination of their audio and video data. The infrastructure of the system includes a plurality of client workstations that are connected to a central server using point-to-point network connections. The central server maintains a persistent virtual world of network places with objects located therein. Streams of audio and video data are coordinated between client workstations operating in the persistent virtual world by a key manager object using channels, transmitters, and receivers. The client workstations multicast their audio and video data over the network to defined recipients after receiving a multicast address and an encryption key for a specific multicast channel.

Abstract: A collaborative object architecture with one or more of the following technologies: 1) lightweight asynchronous messaging; 2) collaborative objects; 3) optimistic concurrency control; and 4) transparent object serialization. Lightweight asynchronous messaging allows highly responsive interactivity and natural interactions with minimal network loads. Collaborative objects allow ubiquitous sharing and provides each user with the same copy of the shared object. Optimistic concurrency control allows full-duplex group editing and natural interactions. Transparent object serialization provides real world persistence and support for asynchronous changes. Thus, combination of these technologies provides a collaborative object architecture with several advantages over the prior art.

Abstract: A client system stores messages and sends the messages to a server system. The messages are included in a request formatted according to a protocol that can traverse a firewall. Then the client system waits for a response from the server system. The response will also be formatted according to the protocol that can traverse the firewall. The response will include an indication of which messages the server system received from the client system in the last request. If a certain number of messages accumulate at the client system, or a certain amount of time passes before the response is received, the client system will send a second request. The server system also stores messages and sends the messages to the client system. The server system waits for a first request and a second request from the client system. If the first request has been received and a particular number of messages have accumulated at the server system, then the server system will send a response corresponding to the first request.

Abstract: A method of use of real time machine control software integrating both event based mode and task based components. In particular, a collection of constructs have been created that allow machine control applications to be expressed in event based terms and the event based constructs to be seamlessly integrated with task based constructs. The method includes the use of response time specifications, in particular in conjunction with ReactiveTask and Task constructs. The method also includes the use of Register, ReferenceClock, and SchedulerLock constructs.

Abstract: A method of use of real time machine control software integrating both event based mode and task based components. In particular, a collection of constructs have been created that allow machine control applications to be expressed in event based terms and the event based constructs to be seamlessly integrated with task based constructs. The method includes the use of response time specifications, in particular in conjunction with ReactiveTask and Task constructs. The method also includes the use of Register, ReferenceClock, and SchedulerLock constructs.

Abstract: A client system stores messages and sends the messages to a server system. The messages are included in a request formatted according to a protocol that can traverse a firewall. Then the client system waits for a response from the server system. The response will also be formatted according to the protocol that can traverse the firewall. The response will include an indication of which messages the server system received from the client system in the last request. If a certain number of messages accumulate at the client system, or a certain amount of time passes before the response is received, the client system will send a second request. The server system also stores messages and sends the messages to the client system. The server system waits for a first request and a second request from the client system. If the first request has been received and a particular number of messages have accumulated at the server system, then the server system will send a response corresponding to the first request.