Abstract: The present disclosure relates to novel compounds for use in therapeutic treatment of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

Abstract: An implantable tissue marker device is provided to be placed in a soft tissue site through a surgical incision. The device can include a bioabsorbable body in the form of a spiral and defining a spheroid shape for the device, the spiral having a longitudinal axis, and turns of the spiral being spaced apart from each other in a direction along the longitudinal axis. A plurality of markers can be disposed on the body, the markers being visualizable by a radiographic imaging device. The turns of the spiral are sufficiently spaced apart to form gaps that allow soft tissue to infiltrate between the turns and to allow flexibility in the device along the longitudinal axis in the manner of a spring.

Abstract: An adaptive pixel multisampler generates pixel data for display by using sub-pixel areas to more broadly define the space of a pixel. A sub-pixel area is defined as having a "hole" within it that is occupied by a portion of each of the adjacent sub-pixel areas. This means that while the sub-pixel areas interlock, they do not overlap which would be wasteful of memory space. Accordingly, a pixel is newly defined as extending over a larger area than a standard contiguous pixel definition of the prior art allows. The larger pixel thus provides a wider sampler area which is then used as a means for generating a higher quality anti-aliased image on the display.

Abstract: A system and method improves pixel update performance in computer graphics systems. Pixel sample coverage masks and data record memory locations are assigned to each pixel. The data record memory locations store pixel sample data for one or more pixel samples. A coverage mask is associated with each data record and contains mask bits which identify the pixel samples that are assigned the data contained in the data record memory location. In another embodiment, the pixels are also assigned versions which are compared with a current version. In response to the version comparison, predefined alternate pixel data or pixel data stored in a frame buffer is blended with new pixel data. The blended pixel data is written to the frame buffer from which it is retrieved and displayed by a display device. In another embodiment, pixel data memory is dynamically allocated to reduce the dedicated memory requirements while still providing high quality images.

Abstract: An adaptive pixel multisampler generates pixel data for display using an interlocking sub-pixel sampling pattern and a frame buffer organized as a per-polygon, per-pixel heap. The interlocking sampling pattern provides the advantages of a multi-pixel shaped filter without pixel-to-pixel cross communication and without additional sub-pixels. The per-polygon, per-pixel heap allocates frame buffer memory so that each pixel will have one set of data stored in the frame buffer for every polygon that influences that pixel. This memory allocation scheme can significantly reduce frame buffer memory requirements. The polygon data is blended to properly handle processing of transparent polygons and polygon edges without the degradation of image quality found in conventional computer graphics systems.

Abstract: Image data is generated and stored for prioritized image levels of a composite graphics display along with certain control and blending data. To composite data levels for a display, individual picture elements (pixels) are generated in accordance with level priority, control signal indications of enablement, control signal indications of color and alpha control signals (object position and transparency). Accordingly, object data from plural levels is selected or blended on a pixel-by-pixel basis to accomplish a desired composite display.