Abstract: In its many embodiments, the present invention provides a novel class of pyrimidine analogs of formula (V) as targeted mechanism-based modulators of cell cycle checkpoints. Cancers and/or malignancies can be treated by administration of a cell cycle checkpoint modulator of the invention. Also discussed are suitable combinations of the cell cycle checkpoint modulator with a checkpoint kinase inhibitor to produce synergistic apoptosis in cancer cells. The invention includes methods of treating cancers by administering the combination of the cell cycle checkpoint modulator and the checkpoint kinase inhibitor, pharmaceutical compositions comprising the activator as well as the combination and pharmaceutical kits.

Abstract: A disposal system is provided. In an embodiment, by way of example, the disposal system can include a first tank adapted to be at least partially filled with waste fluid. The disposal system can also include a waste processing device adapted to receive waste fluid and adjust one or more properties of the waste fluid. Additionally, the waste disposal system can include a jet engine comprising a first chamber adapted to contain a fluid undergoing compression. The jet engine can be in fluid communication with the waste processing device to receive the waste fluid from the waste processing device.

Abstract: Provided are methods, systems and devices for providing a synthetic window system for vehicles with limited visibility for passengers. Various embodiments include demountably affixing video display devices within one or more interior bulkheads such that all marginal edge portions of a viewing screen of the video display device are flushly surrounded by the first interior bulkhead. A video capture device provides a video signal to the video display device, the video capture device capturing a view from a vantage point located outside of the vehicle and in proximity to the video display device for viewing on the viewing screen of the video display device via the video signal.

Abstract: Systems and methods for indicating status of a piston engine magneto (MAG). An example system includes a MAG sensing circuit that senses a signal from the MAG and an indication device that output an indication of the operational status of the MAG based on the sensed signal. The MAG sensing circuit samples a signal from a P-lead of the MAG. The indication device determines if the sampled signal is below a predefined threshold value. The indication device includes a field effect transistor (FET) that receives the sampled signal at its gate. The FET is placed in an on state if the sampled signal is above the predefined threshold value, and the FET is placed in an off state if the sampled signal is below the predefined threshold value. A light is activated when the FET is in the on state and deactivated when the FET is in the off state.

Abstract: An improved heating system air pressure sensing port. An example aircraft pitot tube heater uses Positive Temperature Coefficient (PTC) switching thermistors arranged to automatically sense the outside air temperature and heat to a design set point temperature. When a high outside air temperature is experienced, the pitot tube will not turn on. The pitot tube heater only turns on below the design set point and will consumes less current than the standard aircraft pitot tube heaters when operating at very cold temperatures. Virtually no current is drawn when the pitot tube increases past the set point, thus reducing the power drain on the aircraft system. The use of multiple thermistors gives the example pitot tube a level of failure redundancy that is not available in current pitot tube heaters.

Abstract: A disposal system is provided. In an embodiment, by way of example, the disposal system can include a first tank adapted to be at least partially filled with waste fluid. The disposal system can also include a waste processing device adapted to receive waste fluid and adjust one or more properties of the waste fluid. Additionally, the waste disposal system can include a jet engine comprising a first chamber adapted to contain a fluid undergoing compression. The jet engine can be in fluid communication with the waste processing device to receive the waste fluid from the waste processing device.

Abstract: Systems and methods for monitoring the stability of a construction machine are provided. A gyroscope is configured to detect an angle of inclination of the construction machine relative to a vertical axis and generate an inclination signal representative thereof. A processor in operable communication with the gyroscope is configured to receive the inclination angle and generate a warning signal when the angle of inclination exceeds a predetermined threshold. An alarm device in operable communication with the processor is configured to generate an alarm to indicate to a user of the construction machine when the angle of inclination has exceeded the predetermined threshold.

Abstract: An apparatus for measuring a volume of liquid within a vessel is described. The apparatus includes a plurality of devices each having electrical properties that are dependent on a temperature of the device, a constant current source coupled to the plurality of devices, and a unit configured to output a signal based on an amount of voltage at by the plurality of devices. The amount of voltage is based on a number of the plurality of devices immersed in the liquid, and a number of the plurality of devices not immersed in the liquid.

Abstract: A sensor unit to detect a stillness event, the sensor unit including a gyroscope attached to a monitored person, a micro-controller communicatively coupled to the gyroscope, and a memory communicatively coupled to receive and to store the angular velocity data with a correlated time. The gyroscope senses an angular velocity of the monitored person and outputs angular velocity data based on the sensed angular velocity. The micro-controller receives the angular velocity data and recognizes a quiescence-pattern data in the angular velocity data.

Abstract: Systems and methods for recording information in a vehicle data recorder device. The vehicle data recorder device includes an inertial measurement unit (IMU), a crash survivable unit having memory, and a microcontroller in data communication with the IMU and the memory. The microcontroller receives angular rate information and acceleration information from the IMU and stores the received angular rate information and acceleration information in the memory. The IMU includes two or more MEMS gyroscopes or ring laser gyroscopes. In one example, the microcontroller stores angular rate information and acceleration information in the memory until a threshold event has occurred. The threshold event includes at least one of the angular rate information or acceleration information indicating zero with respect to a rotating earth coordinate frame for a predetermined period of time.

Abstract: A method for monitoring a container is disclosed. The method involves recording a plurality of forces experienced by the container with an electronic detection device and storing each recorded experience from the electronic detection device as tracking data, the tracking data comprising a corresponding date and time of occurrence. Based on the tracking data, the method determines when the container is exposed to a predetermined amount of excessive force.

Abstract: An apparatus for measuring a volume of liquid within a vessel is described. The apparatus includes a plurality of devices each having electrical properties that are dependent on a temperature of the device, a constant current source coupled to the plurality of devices, and a unit configured to output a signal based on an amount of voltage at by the plurality of devices. The amount of voltage is based on a number of the plurality of devices immersed in the liquid, and a number of the plurality of devices not immersed in the liquid.

Abstract: A sensor unit to detect a falling event that includes a gyroscope attached to a monitored person, a micro-controller communicatively coupled to the gyroscope, and a memory communicatively coupled to receive and to store angular velocity data with a correlated time. The gyroscope senses an angular velocity of the monitored person and outputs the angular velocity data based on the sensed angular velocity. The micro-controller receives the angular velocity data and recognizes falling-pattern data in the angular velocity data.

Abstract: A sensor unit to detect a stillness event, the sensor unit including a gyroscope attached to a monitored person, a micro-controller communicatively coupled to the gyroscope, and a memory communicatively coupled to receive and to store the angular velocity data with a correlated time. The gyroscope senses an angular velocity of the monitored person and outputs angular velocity data based on the sensed angular velocity. The micro-controller receives the angular velocity data and recognizes a quiescence-pattern data in the angular velocity data.

Abstract: An electronic sensor is disclosed. The electronic sensor includes a processor, a processor memory coupled to the processor, and at least one input/output block in communication with the processor and with at least one external component monitor. The sensor further includes one or more accelerometers in communication with the processor and coupled directly to at least one component, the one or more accelerometers sensing one or more mechanical vibrations from the at least one component, and the one or more mechanical vibrations oscillating below 1 MHz. The processor compares the one or more mechanical vibrations with a plurality of vibration samples programmed into the processor memory, each vibration sample specific to at least one sensor application.

Abstract: A method for testing a unit is described where the unit includes one or more of electrical, electronic, mechanical, and electromechanical components. The described method includes applying at least one stimulus to the unit, receiving sound emissions from the unit, converting the sound emissions into one or more acoustic signatures, comparing the acoustic signatures based on the received emissions to stored acoustic signatures expected as a result of the at least one stimulus, and determining a status for the unit based on the comparisons.