Patents by Inventor Michael D'Erasmo

Michael D'Erasmo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleoside Prodrugs and Uses Related Thereto
    Publication number: 20240360163
    Abstract: Disclosed are acyclic nucleoside prodrugs with improved metabolic stability and oral bioavailability. In general, the prodrugs are derivatives of acyclic nucleoside phosphonates containing a lipid-like moiety that can increase oral absorption and subsequent stability in the liver and plasma. Preferably, the lipid-like moiety can resist enzyme-mediated ?-oxidation, such as ?-oxidation catalyzed by cytochrome P450 enzymes. Also disclosed are pharmaceutical formulations of the acyclic nucleoside prodrugs. The acyclic nucleoside prodrugs and pharmaceutical formulations thereof can be used to treat viral infections, such as HIV infections, and/or viral-associated cancer, such as HPV-associated cancers.
    Type: Application
    Filed: June 27, 2024
    Publication date: October 31, 2024
    Inventors: Eric Miller, Nicole Pribut, Michael D'Erasmo, Madhuri Dasari, Dennis C. Liotta
  • Nucleoside prodrugs and uses related thereto
    Patent number: 12049474
    Abstract: Disclosed are acyclic nucleoside prodrugs with improved metabolic stability and oral bioavailability. In general, the prodrugs are derivatives of acyclic nucleoside phosphonates containing a lipid-like moiety that can increase oral absorption and subsequent stability in the liver and plasma. Preferably, the lipid-like moiety can resist enzyme-mediated ?-oxidation, such as ?-oxidation catalyzed by cytochrome P450 enzymes. Also disclosed are pharmaceutical formulations of the acyclic nucleoside prodrugs. The acyclic nucleoside prodrugs and pharmaceutical formulations thereof can be used to treat viral infections, such as HIV infections, and/or viral-associated cancer, such as HPV-associated cancers.
    Type: Grant
    Filed: August 24, 2020
    Date of Patent: July 30, 2024
    Assignee: Emory University
    Inventors: Eric Miller, Nicole Pribut, Michael D'Erasmo, Madhuri Dasari, Kyle Giesler, Sabrina Iskandar, Dennis C. Liotta