Abstract: The present invention provides methods for the diagnosis, prognosis and treatment of HCV-related disease. The method takes advantage of a novel reactive mechanism of the murine monoclonal antibody (mAb) 1F7 against human antibodies specific for different proteins of the Hepatitis C Virus (HCV) and Human immunodeficiency virus (HIV). 1F7 recognizes antibodies against HCV core protein in a majority of HCV-infected individuals and antibodies against HCV non-structural proteins 3 (NS3) and NS4 in some HCV-infected individuals. 1F7 also recognizes antibodies against the putative principle neutralizing determinant (hypervariable and conserved region 1 of the HCV E2 protein) of HCV. The antibody can be used in various methods to detect HCV related disease and formulated with physiologically acceptable carriers in various compositions to treat HCV infection.

Abstract: The present invention provides methods for the diagnosis, prognosis and treatment of HCV-related disease. The method takes advantage of a novel reactive mechanism of the murine monoclonal antibody (mAb) 1F7 against human antibodies specific for different proteins of the Hepatitis C Virus (HCV) and Human immunodeficiency virus (HIV). 1F7 recognizes antibodies against HCV core protein in a majority of HCV-infected individuals and antibodies against HCV non-structural proteins 3 (NS3) and NS4 in some HCV-infected individuals. 1F7 also recognizes antibodies against the putative principle neutralizing determinant (hypervariable and conserved region 1 of the HCV E2 protein) of HCV. The antibody can be used in various methods to detect HCV related disease and formulated with physiologically acceptable carriers in various compositions to treat HCV infection.

Abstract: A natural gas cylinder fitting and solenoid valve includes a solenoid-actuated poppet co-operating with an O-ring clamped to the floor of the valve cavity to selectively prevent or permit the passage of gas between a gas line and a natural gas cylinder. In an internally mounted embodiment, a fitting body adapted to be engaged in the neck of a cylinder isolates a low pressure region containing the electrical components of the solenoid.

Abstract: A sheet of book index tabs has a backing with a release coating and a plurality of index tabs on the backing sheet separated from each other by die-cut lines. Each index tab has a transparent film layer and transparent pressure sensitive adhesive which is temporarily attached to the release coating. Each tab has a centrally located, substantially opaque band of ink extending across the tab. Stripes of dark ink are printed along each edge of the band with each stripe being an equal distance from the adjacent edge of the tab. A score line on the bottom of the backing is centered opposite the center of the band of ink to facilitate creasing of the backing and index tab. The tab takes a permanent set along the crease and separates from the release coating along the set to facilitate peeling from the backing. Upon folding the index tab along the crease, the dark stripes are superimposed for placement along the edge of a document page as an aid to alignment.