Patents by Inventor Michael D. Harrison

Michael D. Harrison has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11970479
    Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: April 30, 2024
    Assignees: Merck Sharp & Dohme LLC, MSD R&D (China) Co. LTD.
    Inventors: John J. Acton, III, Melissa Egbertson, Xiaolei Gao, Scott T. Harrison, Timothy J. Henderson, Michael Man-Chu Lo, Robert D. Mazzola, Jr., Zhaoyang Meng, James Mulhearn, Vanessa L. Rada, Jeffrey W. Schubert, Oleg B. Selyutin, David M. Tellers, Ling Tong, Fengqi Zhang, Jianming Bao, Chunsing Li
  • Publication number: 20210051991
    Abstract: A low or zero calorie sweetener composition with sweetness synergy, providing a reduction in off-taste and a desirable temporal profile. The sweetener composition is suitable for use as a substitute for high calorie sugars. The sweetener composition is for use in food and beverage products, pharmaceutical products, nutritional product and cosmetic products.
    Type: Application
    Filed: November 9, 2020
    Publication date: February 25, 2021
    Applicant: Tate & Lyle Ingredients Americas LLC
    Inventors: Ryan D. Woodyer, Jason C. Cohen, John R. Bridges, Michael D. Harrison, Yuqing Zhou
  • Publication number: 20200032309
    Abstract: A food product comprises an oligosaccharide composition that is digestion resistant or slowly digestible. The oligosaccharide composition can be produced by a process that comprises producing an aqueous composition that comprises at least one oligosaccharide and at least one monosaccharide by saccharification of starch, membrane filtering the aqueous composition to form a monosaccharide-rich stream and an oligosaccharide-rich stream, and recovering the oligosaccharide-rich stream. Alternatively, the oligosaccharide composition can be produced by a process that comprises heating an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and that has a solids concentration of at least about 70% by weight, to a temperature of at least about 40° C.
    Type: Application
    Filed: July 2, 2019
    Publication date: January 30, 2020
    Inventors: Michael D. Harrison, Andrew J. Hoffman
  • Patent number: 10344308
    Abstract: A food product comprises an oligosaccharide composition that is digestion resistant or slowly digestible. The oligosaccharide composition can be produced by a process that comprises producing an aqueous composition that comprises at least one oligosaccharide and at least one monosaccharide by saccharification of starch, membrane filtering the aqueous composition to form a monosaccharide-rich stream and an oligosaccharide-rich stream, and recovering the oligosaccharide-rich stream. Alternatively, the oligosaccharide composition can be produced by a process that comprises heating an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and that has a solids concentration of at least about 70% by weight, to a temperature of at least about 40° C.
    Type: Grant
    Filed: March 22, 2018
    Date of Patent: July 9, 2019
    Assignee: Tate & Lyle Ingredients Americas LLC
    Inventors: Michael D. Harrison, Andrew J. Hoffman
  • Publication number: 20180371514
    Abstract: A food product comprises an oligosaccharide composition that is digestion resistant or slowly digestible. The oligosaccharide composition can be produced by a process that comprises producing an aqueous composition that comprises at least one oligosaccharide and at least one monosaccharide by saccharification of starch, membrane filtering the aqueous composition to form a monosaccharide-rich stream and an oligosaccharide-rich stream, and recovering the oligosaccharide-rich stream. Alternatively, the oligosaccharide composition can be produced by a process that comprises heating an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and that has a solids concentration of at least about 70% by weight, to a temperature of at least about 40° C.
    Type: Application
    Filed: March 22, 2018
    Publication date: December 27, 2018
    Inventors: Michael D. Harrison, Andrew J. Hoffman
  • Patent number: 9963726
    Abstract: A food product comprises an oligosaccharide composition that is digestion resistant or slowly digestible. The oligosaccharide composition can be produced by a process that comprises producing an aqueous composition that comprises at least one oligosaccharide and at least one monosaccharide by saccharification of starch, membrane filtering the aqueous composition to form a monosaccharide-rich stream and an oligosaccharide-rich stream, and recovering the oligosaccharide-rich stream. Alternatively, the oligosaccharide composition can be produced by a process that comprises heating an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and that has a solids concentration of at least about 70% by weight, to a temperature of at least about 40° C.
    Type: Grant
    Filed: August 31, 2017
    Date of Patent: May 8, 2018
    Assignee: Tate & Lyle Ingredients Americas LLC
    Inventors: Michael D. Harrison, Andrew J. Hoffman
  • Patent number: 9957537
    Abstract: A food product comprises an oligosaccharide composition that is digestion resistant or slowly digestible. The oligosaccharide composition can be produced by a process that comprises producing an aqueous composition that comprises at least one oligosaccharide and at least one monosaccharide by saccharification of starch, membrane filtering the aqueous composition to form a monosaccharide-rich stream and an oligosaccharide-rich stream, and recovering the oligosaccharide-rich stream. Alternatively, the oligosaccharide composition can be produced by a process that comprises heating an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and that has a solids concentration of at least about 70% by weight, to a temperature of at least about 40° C.
    Type: Grant
    Filed: July 25, 2017
    Date of Patent: May 1, 2018
    Assignee: Tate & Lyle Ingredients Americas LLC
    Inventors: Michael D. Harrison, Andrew J. Hoffman
  • Publication number: 20180030489
    Abstract: A food product comprises an oligosaccharide composition that is digestion resistant or slowly digestible. The oligosaccharide composition can be produced by a process that comprises producing an aqueous composition that comprises at least one oligosaccharide and at least one monosaccharide by saccharification of starch, membrane filtering the aqueous composition to form a monosaccharide-rich stream and an oligosaccharide-rich stream, and recovering the oligosaccharide-rich stream. Alternatively, the oligosaccharide composition can be produced by a process that comprises heating an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and that has a solids concentration of at least about 70% by weight, to a temperature of at least about 40° C.
    Type: Application
    Filed: August 31, 2017
    Publication date: February 1, 2018
    Applicant: Tate & Lyle Ingredients Americas LLC
    Inventors: Michael D. Harrison, Andrew J. Hoffman
  • Patent number: 9868969
    Abstract: A food product comprises an oligosaccharide composition that is digestion resistant or slowly digestible. The oligosaccharide composition can be produced by a process that comprises producing an aqueous composition that comprises at least one oligosaccharide and at least one monosaccharide by saccharification of starch, membrane filtering the aqueous composition to form a monosaccharide-rich stream and an oligosaccharide-rich stream, and recovering the oligosaccharide-rich stream. Alternatively, the oligosaccharide composition can be produced by a process that comprises heating an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and that has a solids concentration of at least about 70% by weight, to a temperature of at least about 40° C.
    Type: Grant
    Filed: January 12, 2015
    Date of Patent: January 16, 2018
    Assignee: Tate & Lyle Ingredients Americas LLC
    Inventors: Michael D. Harrison, Andrew J. Hoffman
  • Publication number: 20170356021
    Abstract: A food product comprises an oligosaccharide composition that is digestion resistant or slowly digestible. The oligosaccharide composition can be produced by a process that comprises producing an aqueous composition that comprises at least one oligosaccharide and at least one monosaccharide by saccharification of starch, membrane filtering the aqueous composition to form a monosaccharide-rich stream and an oligosaccharide-rich stream, and recovering the oligosaccharide-rich stream. Alternatively, the oligosaccharide composition can be produced by a process that comprises heating an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and that has a solids concentration of at least about 70% by weight, to a temperature of at least about 40° C.
    Type: Application
    Filed: July 25, 2017
    Publication date: December 14, 2017
    Applicant: Tate & Lyle Ingredients Americas LLC
    Inventors: Michael D. Harrison, Andrew J. Hoffman
  • Publication number: 20160302463
    Abstract: The present invention relates to the use of high levels of allulose in food and beverage products.
    Type: Application
    Filed: November 21, 2014
    Publication date: October 20, 2016
    Applicant: Tate & Lyle Ingredients Americas LLC
    Inventors: Ryan D. WOODYER, Michael D. HARRISON, Annah LE, Yuqing ZHOU, Adrienne Stucky POHRTE, David HOYDA, Jacob DURBIN, Sanjiv H. AVASHIA, Penny PATTON, Jason C. COHEN, Rachel A. WICKLUND, Valerie VANDAELE, Shondra COOK, Carol RAINFORD, Lisa TOUHY, Rosemary SIKORA
  • Publication number: 20160029678
    Abstract: A low or zero calorie sweetener composition with sweetness synergy, providing a reduction in off-taste and a desirable temporal profile. The sweetener composition is suitable for use as a substitute for high calorie sugars. The sweetener composition is for use in food and beverage products, pharmaceutical products, nutritional product and cosmetic products.
    Type: Application
    Filed: March 14, 2014
    Publication date: February 4, 2016
    Applicant: Tate & Lyle Ingredients Americas LLC
    Inventors: Ryan D. WOODYER, Jason C. COHEN, John R. BRIDGES, Michael D. HARRISON, Yuqing ZHOU
  • Publication number: 20150181918
    Abstract: A food product comprises an oligosaccharide composition that is digestion resistant or slowly digestible. The oligosaccharide composition can be produced by a process that comprises producing an aqueous composition that comprises at least one oligosaccharide and at least one monosaccharide by saccharification of starch, membrane filtering the aqueous composition to form a monosaccharide-rich stream and an oligosaccharide-rich stream, and recovering the oligosaccharide-rich stream. Alternatively, the oligosaccharide composition can be produced by a process that comprises heating an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and that has a solids concentration of at least about 70% by weight, to a temperature of at least about 40° C.
    Type: Application
    Filed: January 12, 2015
    Publication date: July 2, 2015
    Applicant: TATE & LYLE INGREDIENTS AMERICAS LLC
    Inventors: Michael D. Harrison, Andrew J. Hoffman
  • Patent number: 8993039
    Abstract: A food product comprising digestion resistant or slowly digestible oligosaccharide composition. The oligosaccharide composition can be produced by a process comprising producing an aqueous composition comprising at least one oligosaccharide and at least one monosaccharide by saccharification of starch, membrane filtering the aqueous composition to form a monosaccharide-rich stream and an oligosaccharide-rich stream, and recovering the oligosaccharide-rich stream. Alternatively, the oligosaccharide composition can be produced by a process comprising heating an aqueous feed composition with a solids concentration of at least about 70% by weight, comprising at least one monosaccharide or linear saccharide oligomer, to a temperature of at least about 40° C.
    Type: Grant
    Filed: October 16, 2007
    Date of Patent: March 31, 2015
    Assignee: Tate & Lyle Ingredients Americas LLC
    Inventors: Michael D. Harrison, Andrew J. Hoffman
  • Patent number: 8137818
    Abstract: Herein disclosed is a composition containing from about 5 weight parts to about 50 weight parts of a branched polylactic acid; from about 50 weight parts to about 95 weight parts of water; and from about 0.1 weight parts to about 1 weight part of a first surfactant. The composition can be coated onto a substrate containing paper or paperboard and having a first surface and a second surface, to form a paper product having oil, grease, and moisture resistance.
    Type: Grant
    Filed: July 21, 2009
    Date of Patent: March 20, 2012
    Assignee: Tate & Lyle Ingredients Americas LLC
    Inventors: Michael D. Harrison, Geoffrey A. R. Nobes, Penelope A. Patton, Shiji Shen, Henk Westerhof
  • Patent number: 8057840
    Abstract: A food product comprises an oligosaccharide composition that is digestion resistant or slowly digestible. The oligosaccharide composition can be produced by a process that comprises producing an aqueous composition that comprises at least one oligosaccharide and at least one monosaccharide by saccharification of starch, membrane filtering the aqueous composition to form a monosaccharide-rich stream and an oligosaccharide-rich stream, and recovering the oligosaccharide-rich stream. Alternatively, the oligosaccharide composition can be produced by a process that comprises heating an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and that has a solids concentration of at least about 70% by weight, to a temperature of at least about 40° C.
    Type: Grant
    Filed: September 15, 2006
    Date of Patent: November 15, 2011
    Assignee: Tate & Lyle Ingredients Americas LLC
    Inventors: Michael D. Harrison, James C. Purdue, Penelope A. Patton, Andrew J. Hoffman, James M. Gaddy, Chi-Li Liu, Robert V. Schanefelt, Richard W. Armentrout, Michelle P. Schwenk, Rachel A. Wicklund, Marianne Claessens, Eric M. Reamer, Shawn E. Sprankle, Sanjiv H. Avashia, Peter M. Gautchier, Robert L. Olsen, Judy L. Turner, Timothy C. Mertz, Michael Bunch, Doris A. Dougherty, Michel Lopez, Lori Napier, Ram Santhanagopalan
  • Publication number: 20100068350
    Abstract: An edible article comprises a food product and a film that encloses the food product. In one embodiment, the film comprises a major amount of pullulan on a dry solids basis, and a minor amount of at least two of glycerol, propylene glycol, sorbitol, and polyethylene glycol. In another embodiment, the film comprises a major amount of pullulan on a dry solids basis, gelatin, and at least two of glycerol, propylene glycol, sorbitol, and polyethylene glycol, and can also comprise salt. In another embodiment, the film comprises a first layer comprising a major amount of at least one food grade wax, a second layer comprising a major amount of pullulan and further comprising at least one plasticizer, and a third layer comprising at least one surfactant that is substantially immiscible with aqueous pullulan compositions but which adheres to pullulan surfaces, wherein the at least one surfactant is at least partially crystalline.
    Type: Application
    Filed: June 13, 2007
    Publication date: March 18, 2010
    Inventors: Shiji SHEN, Andrew HOFFMAN, Michael D. HARRISON, Susan E. BUTLER, Erin S. CRISWELL, Penelope PATTON
  • Publication number: 20100047432
    Abstract: A process for preparing saccharide oligomers uses an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and has a solids concentration of at least about 70% by weight. The feed composition is heated to a temperature of at least about 40° C., and is contacted with at least one catalyst that accelerates the rate of cleavage or formation of glucosyl bonds, such as enzyme or acid, for a time sufficient to cause formation of non-linear saccharide oligomers. A product composition is produced that contains a higher concentration of non-linear saccharide oligomers than linear saccharide oligomers.
    Type: Application
    Filed: August 24, 2009
    Publication date: February 25, 2010
    Inventors: Michael D. Harrison, James C. Purdue, Penelope A. Patton, Andrew Hoffman, James M. Gaddy, Chi-Li Liu, Robert Schanefelt
  • Publication number: 20100021751
    Abstract: Herein disclosed is a composition containing from about 5 weight parts to about 50 weight parts of a branched polylactic acid; from about 50 weight parts to about 95 weight parts of water; and from about 0.1 weight parts to about 1 weight part of a first surfactant. The composition can be coated onto a substrate containing paper or paperboard and having a first surface and a second surface, to form a paper product having oil, grease, and moisture resistance.
    Type: Application
    Filed: July 21, 2009
    Publication date: January 28, 2010
    Inventors: Michael D. Harrison, Geoffrey A.R. Nobes, Penelope Patton, Shiji Shen, Henk Westerhof
  • Publication number: 20090286907
    Abstract: We disclose a composition containing a polyester comprising about 1 mole part diol units and from about 0.98 mole parts fumaric acid units to about 1.01 mole parts fumaric acid units. In one embodiment, the diol units are 1,3-propanediol units or 1,2-propanediol units. In one embodiment, the polyester is blended with polylactide. In another embodiment, the composition is in a form selected from the group consisting of a plate, a tray, a bowl, a cup, a bowl lid, a cup lid, a fork, a spoon, a knife, a jewel case, and a packaging article. We also disclose a method of manufacturing the composition. The method includes combining about 1 mole part diol, from about 0.98 mole parts fumaric acid to about 1.01 mole parts fumaric acid, and from about 0.0002 mole parts to about 0.0020 mole parts of a polyesterfication catalyst, to yield a combination of diol and fumaric acid; maintaining the combination of diol and fumaric acid under an inert atmosphere at a temperature from about 130° C. to about 190° C.
    Type: Application
    Filed: January 16, 2009
    Publication date: November 19, 2009
    Inventors: Mark W. Beltz, Susan Butler, Mark Daniel Cassidy, Timothy Russell Cooper, Erin S. Criswell, Michael D. Harrison, Sarah Massey