Patents by Inventor Michael D. Harrison
Michael D. Harrison has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11970479Abstract: The present invention is directed to cinnolinyl and quinolinyl pyrazol-4-yl-pyridine compounds which are allosteric modulators of the M4 muscarinic acetylcholine receptor. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which M4 muscarinic acetylcholine receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which M4 muscarinic acetylcholine receptors are involved.Type: GrantFiled: October 24, 2019Date of Patent: April 30, 2024Assignees: Merck Sharp & Dohme LLC, MSD R&D (China) Co. LTD.Inventors: John J. Acton, III, Melissa Egbertson, Xiaolei Gao, Scott T. Harrison, Timothy J. Henderson, Michael Man-Chu Lo, Robert D. Mazzola, Jr., Zhaoyang Meng, James Mulhearn, Vanessa L. Rada, Jeffrey W. Schubert, Oleg B. Selyutin, David M. Tellers, Ling Tong, Fengqi Zhang, Jianming Bao, Chunsing Li
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Publication number: 20210051991Abstract: A low or zero calorie sweetener composition with sweetness synergy, providing a reduction in off-taste and a desirable temporal profile. The sweetener composition is suitable for use as a substitute for high calorie sugars. The sweetener composition is for use in food and beverage products, pharmaceutical products, nutritional product and cosmetic products.Type: ApplicationFiled: November 9, 2020Publication date: February 25, 2021Applicant: Tate & Lyle Ingredients Americas LLCInventors: Ryan D. Woodyer, Jason C. Cohen, John R. Bridges, Michael D. Harrison, Yuqing Zhou
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Publication number: 20200032309Abstract: A food product comprises an oligosaccharide composition that is digestion resistant or slowly digestible. The oligosaccharide composition can be produced by a process that comprises producing an aqueous composition that comprises at least one oligosaccharide and at least one monosaccharide by saccharification of starch, membrane filtering the aqueous composition to form a monosaccharide-rich stream and an oligosaccharide-rich stream, and recovering the oligosaccharide-rich stream. Alternatively, the oligosaccharide composition can be produced by a process that comprises heating an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and that has a solids concentration of at least about 70% by weight, to a temperature of at least about 40° C.Type: ApplicationFiled: July 2, 2019Publication date: January 30, 2020Inventors: Michael D. Harrison, Andrew J. Hoffman
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Patent number: 10344308Abstract: A food product comprises an oligosaccharide composition that is digestion resistant or slowly digestible. The oligosaccharide composition can be produced by a process that comprises producing an aqueous composition that comprises at least one oligosaccharide and at least one monosaccharide by saccharification of starch, membrane filtering the aqueous composition to form a monosaccharide-rich stream and an oligosaccharide-rich stream, and recovering the oligosaccharide-rich stream. Alternatively, the oligosaccharide composition can be produced by a process that comprises heating an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and that has a solids concentration of at least about 70% by weight, to a temperature of at least about 40° C.Type: GrantFiled: March 22, 2018Date of Patent: July 9, 2019Assignee: Tate & Lyle Ingredients Americas LLCInventors: Michael D. Harrison, Andrew J. Hoffman
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Publication number: 20180371514Abstract: A food product comprises an oligosaccharide composition that is digestion resistant or slowly digestible. The oligosaccharide composition can be produced by a process that comprises producing an aqueous composition that comprises at least one oligosaccharide and at least one monosaccharide by saccharification of starch, membrane filtering the aqueous composition to form a monosaccharide-rich stream and an oligosaccharide-rich stream, and recovering the oligosaccharide-rich stream. Alternatively, the oligosaccharide composition can be produced by a process that comprises heating an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and that has a solids concentration of at least about 70% by weight, to a temperature of at least about 40° C.Type: ApplicationFiled: March 22, 2018Publication date: December 27, 2018Inventors: Michael D. Harrison, Andrew J. Hoffman
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Patent number: 9963726Abstract: A food product comprises an oligosaccharide composition that is digestion resistant or slowly digestible. The oligosaccharide composition can be produced by a process that comprises producing an aqueous composition that comprises at least one oligosaccharide and at least one monosaccharide by saccharification of starch, membrane filtering the aqueous composition to form a monosaccharide-rich stream and an oligosaccharide-rich stream, and recovering the oligosaccharide-rich stream. Alternatively, the oligosaccharide composition can be produced by a process that comprises heating an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and that has a solids concentration of at least about 70% by weight, to a temperature of at least about 40° C.Type: GrantFiled: August 31, 2017Date of Patent: May 8, 2018Assignee: Tate & Lyle Ingredients Americas LLCInventors: Michael D. Harrison, Andrew J. Hoffman
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Patent number: 9957537Abstract: A food product comprises an oligosaccharide composition that is digestion resistant or slowly digestible. The oligosaccharide composition can be produced by a process that comprises producing an aqueous composition that comprises at least one oligosaccharide and at least one monosaccharide by saccharification of starch, membrane filtering the aqueous composition to form a monosaccharide-rich stream and an oligosaccharide-rich stream, and recovering the oligosaccharide-rich stream. Alternatively, the oligosaccharide composition can be produced by a process that comprises heating an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and that has a solids concentration of at least about 70% by weight, to a temperature of at least about 40° C.Type: GrantFiled: July 25, 2017Date of Patent: May 1, 2018Assignee: Tate & Lyle Ingredients Americas LLCInventors: Michael D. Harrison, Andrew J. Hoffman
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Publication number: 20180030489Abstract: A food product comprises an oligosaccharide composition that is digestion resistant or slowly digestible. The oligosaccharide composition can be produced by a process that comprises producing an aqueous composition that comprises at least one oligosaccharide and at least one monosaccharide by saccharification of starch, membrane filtering the aqueous composition to form a monosaccharide-rich stream and an oligosaccharide-rich stream, and recovering the oligosaccharide-rich stream. Alternatively, the oligosaccharide composition can be produced by a process that comprises heating an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and that has a solids concentration of at least about 70% by weight, to a temperature of at least about 40° C.Type: ApplicationFiled: August 31, 2017Publication date: February 1, 2018Applicant: Tate & Lyle Ingredients Americas LLCInventors: Michael D. Harrison, Andrew J. Hoffman
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Patent number: 9868969Abstract: A food product comprises an oligosaccharide composition that is digestion resistant or slowly digestible. The oligosaccharide composition can be produced by a process that comprises producing an aqueous composition that comprises at least one oligosaccharide and at least one monosaccharide by saccharification of starch, membrane filtering the aqueous composition to form a monosaccharide-rich stream and an oligosaccharide-rich stream, and recovering the oligosaccharide-rich stream. Alternatively, the oligosaccharide composition can be produced by a process that comprises heating an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and that has a solids concentration of at least about 70% by weight, to a temperature of at least about 40° C.Type: GrantFiled: January 12, 2015Date of Patent: January 16, 2018Assignee: Tate & Lyle Ingredients Americas LLCInventors: Michael D. Harrison, Andrew J. Hoffman
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Publication number: 20170356021Abstract: A food product comprises an oligosaccharide composition that is digestion resistant or slowly digestible. The oligosaccharide composition can be produced by a process that comprises producing an aqueous composition that comprises at least one oligosaccharide and at least one monosaccharide by saccharification of starch, membrane filtering the aqueous composition to form a monosaccharide-rich stream and an oligosaccharide-rich stream, and recovering the oligosaccharide-rich stream. Alternatively, the oligosaccharide composition can be produced by a process that comprises heating an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and that has a solids concentration of at least about 70% by weight, to a temperature of at least about 40° C.Type: ApplicationFiled: July 25, 2017Publication date: December 14, 2017Applicant: Tate & Lyle Ingredients Americas LLCInventors: Michael D. Harrison, Andrew J. Hoffman
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Publication number: 20160302463Abstract: The present invention relates to the use of high levels of allulose in food and beverage products.Type: ApplicationFiled: November 21, 2014Publication date: October 20, 2016Applicant: Tate & Lyle Ingredients Americas LLCInventors: Ryan D. WOODYER, Michael D. HARRISON, Annah LE, Yuqing ZHOU, Adrienne Stucky POHRTE, David HOYDA, Jacob DURBIN, Sanjiv H. AVASHIA, Penny PATTON, Jason C. COHEN, Rachel A. WICKLUND, Valerie VANDAELE, Shondra COOK, Carol RAINFORD, Lisa TOUHY, Rosemary SIKORA
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Publication number: 20160029678Abstract: A low or zero calorie sweetener composition with sweetness synergy, providing a reduction in off-taste and a desirable temporal profile. The sweetener composition is suitable for use as a substitute for high calorie sugars. The sweetener composition is for use in food and beverage products, pharmaceutical products, nutritional product and cosmetic products.Type: ApplicationFiled: March 14, 2014Publication date: February 4, 2016Applicant: Tate & Lyle Ingredients Americas LLCInventors: Ryan D. WOODYER, Jason C. COHEN, John R. BRIDGES, Michael D. HARRISON, Yuqing ZHOU
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Publication number: 20150181918Abstract: A food product comprises an oligosaccharide composition that is digestion resistant or slowly digestible. The oligosaccharide composition can be produced by a process that comprises producing an aqueous composition that comprises at least one oligosaccharide and at least one monosaccharide by saccharification of starch, membrane filtering the aqueous composition to form a monosaccharide-rich stream and an oligosaccharide-rich stream, and recovering the oligosaccharide-rich stream. Alternatively, the oligosaccharide composition can be produced by a process that comprises heating an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and that has a solids concentration of at least about 70% by weight, to a temperature of at least about 40° C.Type: ApplicationFiled: January 12, 2015Publication date: July 2, 2015Applicant: TATE & LYLE INGREDIENTS AMERICAS LLCInventors: Michael D. Harrison, Andrew J. Hoffman
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Patent number: 8993039Abstract: A food product comprising digestion resistant or slowly digestible oligosaccharide composition. The oligosaccharide composition can be produced by a process comprising producing an aqueous composition comprising at least one oligosaccharide and at least one monosaccharide by saccharification of starch, membrane filtering the aqueous composition to form a monosaccharide-rich stream and an oligosaccharide-rich stream, and recovering the oligosaccharide-rich stream. Alternatively, the oligosaccharide composition can be produced by a process comprising heating an aqueous feed composition with a solids concentration of at least about 70% by weight, comprising at least one monosaccharide or linear saccharide oligomer, to a temperature of at least about 40° C.Type: GrantFiled: October 16, 2007Date of Patent: March 31, 2015Assignee: Tate & Lyle Ingredients Americas LLCInventors: Michael D. Harrison, Andrew J. Hoffman
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Patent number: 8137818Abstract: Herein disclosed is a composition containing from about 5 weight parts to about 50 weight parts of a branched polylactic acid; from about 50 weight parts to about 95 weight parts of water; and from about 0.1 weight parts to about 1 weight part of a first surfactant. The composition can be coated onto a substrate containing paper or paperboard and having a first surface and a second surface, to form a paper product having oil, grease, and moisture resistance.Type: GrantFiled: July 21, 2009Date of Patent: March 20, 2012Assignee: Tate & Lyle Ingredients Americas LLCInventors: Michael D. Harrison, Geoffrey A. R. Nobes, Penelope A. Patton, Shiji Shen, Henk Westerhof
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Patent number: 8057840Abstract: A food product comprises an oligosaccharide composition that is digestion resistant or slowly digestible. The oligosaccharide composition can be produced by a process that comprises producing an aqueous composition that comprises at least one oligosaccharide and at least one monosaccharide by saccharification of starch, membrane filtering the aqueous composition to form a monosaccharide-rich stream and an oligosaccharide-rich stream, and recovering the oligosaccharide-rich stream. Alternatively, the oligosaccharide composition can be produced by a process that comprises heating an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and that has a solids concentration of at least about 70% by weight, to a temperature of at least about 40° C.Type: GrantFiled: September 15, 2006Date of Patent: November 15, 2011Assignee: Tate & Lyle Ingredients Americas LLCInventors: Michael D. Harrison, James C. Purdue, Penelope A. Patton, Andrew J. Hoffman, James M. Gaddy, Chi-Li Liu, Robert V. Schanefelt, Richard W. Armentrout, Michelle P. Schwenk, Rachel A. Wicklund, Marianne Claessens, Eric M. Reamer, Shawn E. Sprankle, Sanjiv H. Avashia, Peter M. Gautchier, Robert L. Olsen, Judy L. Turner, Timothy C. Mertz, Michael Bunch, Doris A. Dougherty, Michel Lopez, Lori Napier, Ram Santhanagopalan
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Publication number: 20100068350Abstract: An edible article comprises a food product and a film that encloses the food product. In one embodiment, the film comprises a major amount of pullulan on a dry solids basis, and a minor amount of at least two of glycerol, propylene glycol, sorbitol, and polyethylene glycol. In another embodiment, the film comprises a major amount of pullulan on a dry solids basis, gelatin, and at least two of glycerol, propylene glycol, sorbitol, and polyethylene glycol, and can also comprise salt. In another embodiment, the film comprises a first layer comprising a major amount of at least one food grade wax, a second layer comprising a major amount of pullulan and further comprising at least one plasticizer, and a third layer comprising at least one surfactant that is substantially immiscible with aqueous pullulan compositions but which adheres to pullulan surfaces, wherein the at least one surfactant is at least partially crystalline.Type: ApplicationFiled: June 13, 2007Publication date: March 18, 2010Inventors: Shiji SHEN, Andrew HOFFMAN, Michael D. HARRISON, Susan E. BUTLER, Erin S. CRISWELL, Penelope PATTON
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Publication number: 20100047432Abstract: A process for preparing saccharide oligomers uses an aqueous feed composition that comprises at least one monosaccharide or linear saccharide oligomer, and has a solids concentration of at least about 70% by weight. The feed composition is heated to a temperature of at least about 40° C., and is contacted with at least one catalyst that accelerates the rate of cleavage or formation of glucosyl bonds, such as enzyme or acid, for a time sufficient to cause formation of non-linear saccharide oligomers. A product composition is produced that contains a higher concentration of non-linear saccharide oligomers than linear saccharide oligomers.Type: ApplicationFiled: August 24, 2009Publication date: February 25, 2010Inventors: Michael D. Harrison, James C. Purdue, Penelope A. Patton, Andrew Hoffman, James M. Gaddy, Chi-Li Liu, Robert Schanefelt
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Publication number: 20100021751Abstract: Herein disclosed is a composition containing from about 5 weight parts to about 50 weight parts of a branched polylactic acid; from about 50 weight parts to about 95 weight parts of water; and from about 0.1 weight parts to about 1 weight part of a first surfactant. The composition can be coated onto a substrate containing paper or paperboard and having a first surface and a second surface, to form a paper product having oil, grease, and moisture resistance.Type: ApplicationFiled: July 21, 2009Publication date: January 28, 2010Inventors: Michael D. Harrison, Geoffrey A.R. Nobes, Penelope Patton, Shiji Shen, Henk Westerhof
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Publication number: 20090286907Abstract: We disclose a composition containing a polyester comprising about 1 mole part diol units and from about 0.98 mole parts fumaric acid units to about 1.01 mole parts fumaric acid units. In one embodiment, the diol units are 1,3-propanediol units or 1,2-propanediol units. In one embodiment, the polyester is blended with polylactide. In another embodiment, the composition is in a form selected from the group consisting of a plate, a tray, a bowl, a cup, a bowl lid, a cup lid, a fork, a spoon, a knife, a jewel case, and a packaging article. We also disclose a method of manufacturing the composition. The method includes combining about 1 mole part diol, from about 0.98 mole parts fumaric acid to about 1.01 mole parts fumaric acid, and from about 0.0002 mole parts to about 0.0020 mole parts of a polyesterfication catalyst, to yield a combination of diol and fumaric acid; maintaining the combination of diol and fumaric acid under an inert atmosphere at a temperature from about 130° C. to about 190° C.Type: ApplicationFiled: January 16, 2009Publication date: November 19, 2009Inventors: Mark W. Beltz, Susan Butler, Mark Daniel Cassidy, Timothy Russell Cooper, Erin S. Criswell, Michael D. Harrison, Sarah Massey