Patents by Inventor Michael D. Helman

Michael D. Helman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for enhancing transdermal penetration and compositions useful therein
    Patent number: 5164406
    Abstract: The present invention provides for a composition containing a pharmacologically active agent and a selected imidazole or an imidazole derivative, such composition exhibiting enhanced penetration of the pharmacologically active agent component when a composition containing the aforementioned components is applied to skin.A method of enhancing dermal penetration of compositions containing a pharmacologically active agent is also provided.
    Type: Grant
    Filed: May 22, 1989
    Date of Patent: November 17, 1992
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Michael D. Helman, Alison B. Lukacsko, Thomas A. Re, F. Christopher Zusi
  • Antiperspirant process and imdazole containing compositions utilizable therein
    Patent number: 5028418
    Abstract: Perspiration is decreased in an area of the skin subject to perspiration by applying to such area an antiperspirant amount of an imidazole derivative of the formula I ##STR1## wherein X is O or S and Y is Cl or H, or a dermatologically acceptable salt thereof, preferably in a dermatologically acceptable compatible vehicle.
    Type: Grant
    Filed: March 19, 1990
    Date of Patent: July 2, 1991
    Assignee: Bristol-Myers Squibb Company
    Inventors: Michael D. Helman, Thomas A. Re
  • Antiperspirant compositions, containing certain antihistamines and certain antihistamine enhancers
    Patent number: 4762704
    Abstract: A topical antiperspirant composition containing an antihistamine selected from the group consisting of antazoline, pyrilamine, tripelennamine, diphenhydramine, phenindamine and their corresponding pharmaceutically acceptable salts and an enhancer for said antihistamine selected from the group consisting of sodium sulfate, glutamic acid; octyl palmitate and propylene glycol methyl ether.
    Type: Grant
    Filed: April 28, 1986
    Date of Patent: August 9, 1988
    Assignee: Bristol-Myers Company
    Inventors: Ronald R. Rafft, Michael D. Helman, Leonard Mackles
  • Alpha adrenergic amine of substantial alpha.sub.2 adrenergic amine activity as an antiperspirant
    Patent number: 4737361
    Abstract: An antiperspirant process and composition wherein the active antiperspirant ingredient is an alpha adrenergic amine that has at least a substantial alpha.sub.2 adrenergic amine activity component.
    Type: Grant
    Filed: June 6, 1986
    Date of Patent: April 12, 1988
    Assignee: Bristol-Myers Company
    Inventors: Ronald R. Rafft, Michael D. Helman