Abstract: The disclosure relates to barcoded polymer nanoparticles for in vivo screening and for in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticles, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, associated with polynucleotide barcodes, for therapeutic delivery, and for high throughput in vivo screening of drug delivery nanoparticles.

Abstract: The invention relates to barcoded nucleic acid nanostructure delivery compositions for in vivo screening for subsequent use in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to nucleic acid nanostructure delivery compositions, such as DNA origami structures, associated with barcodes for high throughput in vivo screening of the nucleic acid nanostructure delivery compositions for subsequent use in drug delivery, and methods therefor.

Abstract: In order to provide unbalanced ringing when an exchange line card provides a balanced ringing output the interface provides a ringing detector in circuit with a customer pair. On detecting balanced ringing signals from the line card, the interface takes over the customer line pair and provides unbalanced ringing signals to the customer and monitors for customer answer. By inserting the interface in circuit at the main distribution frame of an exchange, legacy customer premises equipment which is unable to respond to balanced signalling can be provided with an appropriate ringing signal without the necessity to provide differing line cards at the exchange.

Abstract: In order to provide unbalanced ringing when an exchange line card provides a balanced ringing output the interface provides a ringing detector in circuit with a customer pair. On detecting balanced ringing signals from the line card, the interface takes over the customer line pair and provides unbalanced ringing signals to the customer and monitors for customer answer. By inserting the interface in circuit at the main distribution frame of an exchange, legacy customer premises equipment which is unable to respond to balanced signalling can be provided with an appropriate ringing signal without the necessity to provide differing line cards at the exchange.

Abstract: A telecommunications network includes a management system for analyzing call detail records (CDR's) from terminating switches. The management system recovers CDR's by polling through switch managers which poll dependent exchanges. CDR's indicating a call clear occurring within a short predetermined time after a call answer are stored and used to indicate potentially faulty access network lines.

Abstract: A telecommunications network includes a management system for analysing call detail records (CDR's) from terminating switches. The management system recovers CDR's by polling through switch managers which poll dependent exchanges. CDR's indicating a call clear occurring within a short predetermined time after a call answer are stored and used to indicate potentially faulty access network lines.

Abstract: A telecommunications network includes digital main switching units and local exchanges. The local exchange is arranged to permit alternative alert signals to consumer premises by way of the local loop. The alternative signals may be cadenced to provide information to apparatus connected in a consumer's premises without causing activation of traditional telephone, facsimile or answering machines. Such information may be supplemented by the presence or absence of a line polarity reversal before the activation signal is sent and by modulated signals, such as FSK signalling.

Abstract: Testing of pre-ringing signalling in a telecommunications network at customer's premises, for example, signalling to activate a caller display unit may be effected remotely. By establishing a test call through the network by way of a dial-back loop to a test telephone number, establishing a second call through the network to the required telephone and simulating pre-termination conditions at network termination, actual signalling tones at the network edge are monitored by corresponding apparatus to that present at customer premises.

Abstract: In a telecommunications network of the kind which handles non-time-critical calls (NTCC) in addition to normal telephony, a congestion indication is transmitted to NTCC transmitting platforms if volume and/or rate limit for a particular communications route or switch is exceeded. Transmitting platforms (9,10,11) establish a transmission rate based on a gapping ration (GR). On receipt of a congestion signal the platforms calculate and Inter call delay based on a random number multiplied by a weighting factor determined from the current value of GR. This provides a period during which calls are not attempted after which GR is adjusted using a common ratio to provide a higher value of GR thus transmission rate (or the rate at which calls are offered) to the congestion route is less onerous. Consecutive call failures result in a rapid increase in the value of GR leading to longer ICDs (to allow the congested route/switch to recover) and a lower traffic loading on recovery.

Abstract: A telecommunications network including a number of digital main switching units connected to local switching units which provide telephony service to consumer premises via local connections provide telemetry services for utilities by way of a telemetry platform. A network management system is responsive to customer service information to cause local switching units to provide customer facilities such as call barring. The local exchange is responsive to signals indicative of a call from the telemetry platform to override any class of service which would normally prevent the telemetry call from being connected. The local exchange and telemetry platform co-operate with customer premises interface equipment to ensure that any conflict between telephony requirement and telemetry requirement is resolved in favor of the telephony customer.