Patents by Inventor Michael D Leach

Michael D Leach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200009304
    Abstract: Apparatus and methods for processing blood are disclosed in which one variation generally comprises a tube defining a channel and an access tube extending into the channel. An open cell matrix configured to entrap red blood cells may be positioned within at least a portion of the channel. Another variation generally comprises a cylindrical tube and a plunger slidably positioned within the channel. The plunger also has a funnel positioned upon the plunger and is movable therewith. Both the plunger and funnel define a fluid channel through and in communication with the cylindrical tube.
    Type: Application
    Filed: June 24, 2019
    Publication date: January 9, 2020
    Applicant: Hanuman Pelican, Inc.
    Inventors: Randy DORIAN, Michael D. LEACH, Richard W. STORRS, Scott R. KING
  • Publication number: 20200009551
    Abstract: Apparatus and methods for separating blood components are disclosed in which an apparatus for separating blood generally includes a tube defining a channel and configured for receiving a quantity of blood and a float contained within the tube and having a density which is predefined so that the float is maintained at equilibrium between a first layer formed from a first fractional component of the blood and a second layer formed from a second fractional component of the blood. Upon completion of the centrifugation, the first layer may be removed from the tube while the float isolates the second layer from the first layer.
    Type: Application
    Filed: June 27, 2019
    Publication date: January 9, 2020
    Applicant: Hanuman Pelican, Inc.
    Inventors: Randy DORIAN, Michael D. LEACH, Richard W. STORRS, Scott R. KING
  • Patent number: 10232104
    Abstract: Separation of a wash liquid from red blood cells is disclosed using a filter separation and pressure differential system. The filter may include a membrane filter.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: March 19, 2019
    Assignee: Biomet Manufacturing, LLC
    Inventor: Michael D. Leach
  • Patent number: 10208095
    Abstract: Non-centrifugal methods for generating a solution rich in interleukin-1 receptor antagonist from a tissue comprising cytokine-producing cells. The solution rich in IL-1ra can also include at least one of sTNF-RI, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-?1, and sIL-1 RII.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: February 19, 2019
    Assignee: Biomet Manufacturing, LLC
    Inventors: Michael D. Leach, Jennifer E. Woodell-May, Joel C. Higgins, Krista O'Shaughnessey
  • Patent number: 10183042
    Abstract: An apparatus may allow separating and collecting a fraction of a sample. The apparatus, when used with a centrifuge, allows for the creation of at least three fractions in the apparatus. It also provides for a new method of extracting the buffy coat phase from a whole blood sample and mesenchymal stem cells from bone reaming material. A buoy system that may include a first buoy portion and a second buoy member operably interconnected may be used to form at least three fractions from a sample during a substantially single centrifugation process. Therefore, the separation of various fractions may be substantially quick and efficient.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: January 22, 2019
    Assignee: Biomet Manufacturing, LLC
    Inventors: Michael D. Leach, Joel C. Higgins, Matthew Swift, Nathan Gordon
  • Patent number: 10143725
    Abstract: Methods for treating pain using a protein solution comprising two or more of IL1-ra, sTNF-R1, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-?1, and sIL-1RII, Compositions may also contain white blood cells and platelets.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: December 4, 2018
    Inventors: Krista O'Shaughnessey, Jennifer E. Woodell-May, Joel C. Higgins, Michael D. Leach
  • Publication number: 20180243376
    Abstract: Methods for making non-immunogenic anti-inflammatory cytokine compositions, comprising (a) obtaining a liquid comprising cytokine producing cells from a mammalian donor; (b) contacting the liquid with a solid extraction material to generate a composition rich in interleukin-1 receptor antagonist; and performing one or both of (i) removing cells from the composition and (ii) freezing the composition. The compositions comprise two or more of IL1-ra, sTNF-R1, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-?1, and sIL-1RII. Compositions may also contain white blood cells and platelets.
    Type: Application
    Filed: January 31, 2018
    Publication date: August 30, 2018
    Inventors: Jeffrey R. Binder, Joel C. Higgins, Michael D. Leach, Krista Toler, Jennifer E. Woodell-May
  • Patent number: 10036006
    Abstract: A system is disclosed for washing a selected component and removing the selected component from a wash material. The selected component may include red blood cells that are washed to remove a rejuvenating solution. The red blood cells may then be removed with various systems, such as a standing acoustic wave system from the wash solution. Pumps and flow restrictors that provide steady flow from pumps that generate pulsed flow are also disclosed.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: July 31, 2018
    Assignee: Biomet Biologics, LLC
    Inventor: Michael D. Leach
  • Publication number: 20180207349
    Abstract: Disclosed is a device for separating a cellular component from a multicomponent fluid. The device can comprise a body, a first acoustic wave generator, and a second acoustic wave propagating component. The body can define a channel having a first surface and a second surface opposite the first surface. The channel can extend along a longitudinal axis from a first end to a second end. The first acoustic wave generator can be coupled to the first surface. The first acoustic wave generator can be configured to generate an acoustic wave having a wavelength. The second acoustic wave propagating component can be coupled to the second surface. The second surface can be spaced an integer fractional multiple of the wavelength from the first surface and each integer factional multiple equals a number of pressure nodes within the channel.
    Type: Application
    Filed: July 22, 2016
    Publication date: July 26, 2018
    Inventors: Randel E. Dorian, Richard Wood Storrs, Michael D. Leach, Ned M. Hamman, Joel Carne
  • Patent number: 9968870
    Abstract: Separation devices for separating a component from a multicomponent mixture are provided. The separation devices can include a body that defines a separation channel with a cross-sectional geometry that is not circular, rectangular, or square. The separation devices can be positioned relative to a base having an acoustic wave generator. A standing bulk acoustic wave generated by the acoustic wave generator can separate one or more components from the multicomponent mixture. Methods are provided for separating one or more components from a multicomponent mixture using the separation devices.
    Type: Grant
    Filed: December 22, 2015
    Date of Patent: May 15, 2018
    Assignee: Biomet Biologics, LLC
    Inventors: David Abeskaron, Michael D. Leach
  • Patent number: 9963693
    Abstract: A system is disclosed for washing a selected component and removing the selected component from a wash material. The selected component may include red blood cells that are washed to remove a rejuvenating solution. The red blood cells may then be removed with various systems, such as a standing acoustic wave system from the wash solution. Pumps and flow restrictors that provide steady flow from pumps that generate pulsed flow are also disclosed.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: May 8, 2018
    Assignee: Biomet Biologics, LLC
    Inventors: Ned M. Hamman, Michael D. Leach, David Abeskarón, Grant D. Cunningham
  • Patent number: 9950035
    Abstract: Methods for making non-immunogenic anti-inflammatory cytokine compositions, comprising (a) obtaining a liquid comprising cytokine producing cells from a mammalian donor; (b) contacting the liquid with a solid extraction material to generate a composition rich in interleukin-1 receptor antagonist; and performing one or both of (i) removing cells from the composition and (ii) freezing the composition. The compositions comprise two or more of IL1-ra, sTNF-R1, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-?1, and sIL-1RII, Compositions may also contain white blood cells and platelets.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: April 24, 2018
    Assignee: Biomet Biologics, LLC
    Inventors: Jeffrey R. Binder, Joel C. Higgins, Michael D. Leach, Krista O'Shaughnessey, Jennifer E. Woodell-May
  • Patent number: 9937445
    Abstract: A material separation system and method is disclosed. The system may include a buoy having a volume that includes or houses a reacting component. The buoy may be placed in a container to hold the material to be separated during a separation procedure. The separated material may be used to various procedures following separation.
    Type: Grant
    Filed: May 5, 2014
    Date of Patent: April 10, 2018
    Assignee: Biomet Biologics, LLC
    Inventors: William King, Jennifer E. Woodell-May, Joel C. Higgins, Michael D. Leach
  • Patent number: 9920313
    Abstract: A system is disclosed for washing a selected component and removing the selected component from a wash material. The selected component may include red blood cells that are washed to remove a rejuvenating solution. The red blood cells may then be removed with various systems, such as a standing acoustic wave system from the wash solution. Pumps and flow restrictors that provide steady flow from pumps that generate pulsed flow are also disclosed.
    Type: Grant
    Filed: October 21, 2014
    Date of Patent: March 20, 2018
    Assignee: Biomet Biologics, LLC
    Inventors: Ned M. Hamman, Michael D. Leach, David Abeskaron
  • Patent number: 9855382
    Abstract: Devices for washing a composition including cells are provided. The devices include a separation channel, a first wave component and a second wave component. The separation channel is positioned between the first and second wave components. Collectively, the wave components generate a standing bulk acoustic wave that isolates cells from the composition.
    Type: Grant
    Filed: March 31, 2015
    Date of Patent: January 2, 2018
    Assignee: Biomet Biologics, LLC
    Inventors: Michael D. Leach, Ned M. Hamman, David Abeskaron, Grant D. Cunningham, Randel Dorian, Richard W. Storrs, Scott R. King
  • Patent number: 9815038
    Abstract: A clotting serum production device including a main chamber, an inlet housing, and an outlet port. The main chamber is defined by a first end wall, a second end wall opposite to the first end wall, and a side wall extending between the first end wall and the second end wall. The inlet housing extends from the first end wall. The inlet housing includes a first inlet port, a second inlet port, and a first conduit extending between the first inlet port and a second conduit. The second conduit extends between the second inlet port and the main chamber. The inlet housing is configured to provide one-way fluid flow from the first inlet port to the second inlet port and to provide one-way fluid flow from the second inlet port to the main chamber. An outlet port is in fluid communication with the main chamber and provides fluid communication with an exterior of the clotting serum production device.
    Type: Grant
    Filed: November 15, 2013
    Date of Patent: November 14, 2017
    Assignee: Biomet Biologics, LLC
    Inventors: Michael D. Leach, Jennifer E. Woodell-May, Hillary Overholser, Joel C. Higgins, Jason Chavarria, Ned M. Hamman
  • Patent number: 9757721
    Abstract: A method for washing a suspension of cells including a suspension fluid and a plurality of cells is provided. The method includes using centripetal force to generate a layer of wash solution against a cylindrical wall and to generate a cell suspension layer adjacent to the layer of wash solution. The method also includes forcing the cells through the layer of wash solution to generate a layer of clean cells. Devices for performing the method are also provided.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: September 12, 2017
    Assignee: Biomet Biologics, LLC
    Inventors: Michael D. Leach, Randel Dorian, Richard W. Storrs, Scott R. King
  • Patent number: 9758806
    Abstract: Acellular compositions for treating inflammation, comprising two or more of IL1-ra, sTNF-R1, sTNF-RII, IGF-I, EGF, HGF, PDGF-AB, PDGF-BB, VEGF, TGF-?1, and sIL-1RII. Components of the acellular compositions may be derived from biologic materials, such as blood clots and urine. Components may also be obtained from cell cultures.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: September 12, 2017
    Assignee: Biomet Biologics, LLC
    Inventors: Jennifer E. Woodell-May, Joel C. Higgins, Michael D. Leach, Krista O'Shaughnessey
  • Patent number: 9719063
    Abstract: Disclosed is a system to separate, enrich, and/or purify a cellular population from a biological tissue, such as a tissue sample. For example, an adipose tissue sample can be acquired and disrupted. The disrupted tissue sample can then be separated and purified. The separated components can include multipotent, pluripotent, or other cell populations.
    Type: Grant
    Filed: August 11, 2014
    Date of Patent: August 1, 2017
    Assignee: Biomet Biologics, LLC
    Inventors: Randel Dorian, Michael D. Leach, Richard W. Storrs, Jason Chavarria
  • Patent number: 9713327
    Abstract: A device for washing a suspension of cells. The device includes a bowl-shaped basin having a top end and a bottom end and an axis extending from the top end to the bottom end, and an inlet port formed in the basin. The inlet port is positioned at an angle to allow for a wash solution to be injected or delivered into the basin and circulate around the basin about the central axis. A suspension of cells can be washed in the circulating wash solution. The circulating wash solution forces the cells to settle at the bottom of the basin, where they can be extracted.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: July 25, 2017
    Assignee: Biomet Biologics, LLC
    Inventor: Michael D. Leach