Abstract: Provided herein are methods and systems for characterizing a nucleic acid molecule from a single cell. A method for characterizing a nucleic acid molecule from a single cell may comprise providing a partition (e.g., droplets or wells) comprising a single cell and a single bead. The single bead may comprise a nucleic acid barcode molecule. A nucleic acid molecule from the single cell and the nucleic acid barcode molecule may be used to generate a barcoded nucleic acid molecule for sequencing, which may be used to determine an epigenetic state or characteristic of the nucleic acid molecule as being associated with the single cell.

Abstract: Methods and compositions for enhancing the therapeutic activity of agents at low doses as a result of improved targeted drug delivery, namely precision delivery, are described. The methods and compositions can be used to decrease the effective administered amounts of active therapeutic agents via precision delivery to targets capable of mediating active transport across the biological barrier formed by the vasculature that lines blood vessels. Antibodies (and other targeting agent species) to precisely deliver an active ingredient (i.e., a therapeutic agent) to cells expressing, for example, a target protein on their cell membranes, are also described, as are methods of treating disease.

Abstract: Systems and methods for providing haptic effects are disclosed. One disclosed system comprises an actuator, a non-volatile memory configured to store a haptic effect profile, and a processor in communication with the actuator and the non-volatile memory. The processor may be configured to receive a sensor signal indicating a movement of a manipulandum, to identify an effect parameter associated with the sensor signal in the haptic effect profile, and to generate an output signal based, at least in part, on the effect parameter. The generated output signal may be configured to cause the actuator to output a haptic effect associated with the effect parameter.

Abstract: Systems and methods for providing haptic effects are disclosed. One disclosed system comprises an actuator, a non-volatile memory configured to store a haptic effect profile, and a processor in communication with the actuator and the non-volatile memory. The processor may be configured to receive a sensor signal indicating a movement of a manipulandum, to identify an effect parameter associated with the sensor signal in the haptic effect profile, and to generate an output signal based, at least in part, on the effect parameter. The generated output signal may be configured to cause the actuator to output a haptic effect associated with the effect parameter.

Abstract: Systems and methods for virtual detents through vibrotactile feedback are described. One described method includes receiving an input signal comprising information associated with the manipulation of an input device and generating a signal configured to cause an actuator to provide a vibrotactile effect to the input device, the vibrotactile effect comprising a virtual detent.

Abstract: Systems and methods for providing haptic effects are disclosed. One disclosed system comprises an actuator, a non-volatile memory configured to store a haptic effect profile, and a processor in communication with the actuator and the non-volatile memory. The processor may be configured to receive a sensor signal indicating a movement of a manipulandum, to identify an effect parameter associated with the sensor signal in the haptic effect profile, and to generate an output signal based, at least in part, on the effect parameter. The generated output signal may be configured to cause the actuator to output a haptic effect associated with the effect parameter.

Abstract: Described herein are one or more techniques related to a touchsurface with level and planar translational travel responsiveness. One or more of the described implementations include an input device having a rigid body including a touchsurface configured to travel along a depression path in response to being depressed by a user. The input device also includes a leveling mechanism that operates in manner to keep the touchsurface substantially level as the touchsurface travels along the depression path in response to being depressed by the user. Furthermore, the input device has a planar-translation-effecting mechanism that defines a planar translation component of the depression path, such that the touchsurface exhibits planar translation as the touchsurface travels along the depression path.

Abstract: Systems and methods for virtual detents through vibrotactile feedback are described. One described method includes receiving an input signal comprising information associated with the manipulation of an input device and generating a signal configured to cause an actuator to provide a vibrotactile effect to the input device, the vibrotactile effect comprising a virtual detent.

Abstract: Disclosed are epidithiodiketopiperazine compounds, pharmaceutical compositions based thereon and methods of treating, reducing or inhibiting transcription and translation of hypoxia-inducible genes.

Abstract: Disclosed are epidithiodiketopiperazine compounds, pharmaceutical compositions based thereon and methods of treating, reducing or inhibiting transcription and translation of hypoxia-inducible genes.

Abstract: Described herein are one or more techniques related to a touchsurface with level and planar translational travel responsiveness. One or more of the described implementations include an input device having a rigid body including a touchsurface configured to travel along a depression path in response to being depressed by a user. The input device also includes a leveling mechanism that operates in manner to keep the touchsurface substantially level as the touchsurface travels along the depression path in response to being depressed by the user. Furthermore, the input device has a planar-translation-effecting mechanism that defines a planar translation component of the depression path, such that the touchsurface exhibits planar translation as the touchsurface travels along the depression path.

Abstract: Described herein are one or more techniques related to a touchsurface with level and planar translational travel responsiveness. One or more of the described implementations include an input device having a rigid body including a touchsurface configured to travel along a depression path in response to being depressed by a user. The input device also includes a leveling mechanism that operates in manner to keep the touchsurface substantially level as the touchsurface travels along the depression path in response to being depressed by the user. Furthermore, the input device has a planar-translation-effecting mechanism that defines a planar translation component of the depression path, such that the touchsurface exhibits planar translation as the touchsurface travels along the depression path.

Abstract: Described herein are techniques related to a leveled touchsurface with planar translational responsiveness to vertical travel. Examples of a touchsurface include a key of a keyboard, touchpad of a laptop, or a touchscreen of a smartphone or tablet computer. With the techniques described herein, the touchsurface is constrained to remain in a level orientation while a user presses the touchsurface like a button or key. Also, with the techniques described herein, a planar-translation-effecting mechanism imparts a planar translation to the touchsurface while it travels vertically (e.g., downward) as the user presses the touchsurface. This Abstract is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

Abstract: The present invention provides an apparatus and system for providing haptic feedback in a user interface. In one embodiment, the apparatus includes a manipulandum, a resistive actuator, and a biasing element disposed between the manipulandum and the resistive actuator. Further, the biasing element is coupled to one of the manipulandum or the resistive actuator and releasably coupled to the housing, the manipulandum or the resistive actuator.

Abstract: Described herein are one or more techniques related to a touchsurface with level and planar translational travel responsiveness. One or more of the described implementations include an input device having a rigid body including a touchsurface configured to travel along a depression path in response to being depressed by a user. The input device also includes a leveling mechanism that operates in manner to keep the touchsurface substantially level as the touchsurface travels along the depression path in response to being depressed by the user. Furthermore, the input device has a planar-translation-effecting mechanism that defines a planar translation component of the depression path, such that the touchsurface exhibits planar translation as the touchsurface travels along the depression path.

Abstract: Described herein are techniques related to a leveled touchsurface with planar translational responsiveness to vertical travel. Examples of a touchsurface include a key of a keyboard, touchpad of a laptop, or a touchscreen of a smartphone or tablet computer. With the techniques described herein, the touchsurface is constrained to remain in a level orientation during planar translational movement between depressed and unpressed positions along a diagonal line with respect to a vertical axis. Also, with the techniques described herein, a planar-translation-effecting mechanism imparts a planar translation to the touchsurface while it travels vertically (e.g., downward) as the user presses the touchsurface. This Abstract is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

Abstract: Described herein are techniques related to a leveled touchsurface with planar translational responsiveness to vertical travel. Examples of a touchsurface include a key of a keyboard, touchpad of a laptop, or a touchscreen of a smartphone or tablet computer. With the techniques described herein, the touchsurface is constrained to remain in a level orientation during planar translational movement between depressed and unpressed positions along a diagonal line with respect to a vertical axis. Also, with the techniques described herein, a planar-translation-effecting mechanism imparts a planar translation to the touchsurface while it travels vertically (e.g., downward) as the user presses the touchsurface. This Abstract is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims.

Abstract: The present invention provides a control knob on a device that allows a user to control functions of the device. In one embodiment, the knob is rotatable in a rotary degree of freedom and moveable in at least one transverse direction approximately perpendicular to the axis. An actuator is coupled to the knob to output a force in the rotary degree of freedom about the axis, thus providing force feedback. In a different embodiment, the knob is provided with force feedback in a rotary degree of freedom about an axis and is also moveable in a linear degree of freedom approximately parallel to the axis, allowing the knob to be pushed and/or pulled by the user. The device controlled by the knob can be a variety of types of devices, such as an audio device, video device, etc. The device can also include a display providing an image updated in response to manipulation of the knob.

Abstract: An apparatus includes a characterization module configured to receive data associated with operational characteristics of a mechanical device, the operational characteristics being associated with a perceptual experience of the mechanical device. A conversion module is coupled to the characterization module. The conversion module is configured to automatically produce, substantially without user intervention, a parametric data set associated with the mechanical device based on the data. In another embodiment, a method includes receiving data associated with operational characteristics of a mechanical device. The operational characteristics are associated with a perceptual experience of the mechanical device. A parametric data set associated with the mechanical device is produced automatically, without user intervention. The parametric data set is associated with the mechanical device based on the data.

Abstract: A haptic control device for use in control-by-wire systems in vehicles. The haptic shift device includes a manipulandum manipulatable by a user. At least one sensor detects a position of the manipulandum. At least one electrically-controlled actuator outputs a force on the shift lever. In some embodiments, the manipulandum is moveable within a pattern and is blocked from areas outside the boundaries of the pattern. The actuator(s) can be active or passive, and/or a variable mechanical gate can be used to implement the pattern. Provided modes can include automatic, manual, and/or sequential modes.