Patents by Inventor Michael D. Mandler

Michael D. Mandler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aminocoumarin compounds and methods of their use
    Patent number: 11713335
    Abstract: Disclosed are aminocoumarin compounds, pharmaceutical compositions containing aminocoumarin compounds, and methods of their use, e.g., in the treatment of a Gram-negative bacterial infection.
    Type: Grant
    Filed: March 12, 2019
    Date of Patent: August 1, 2023
    Assignee: President and Fellows of Harvard College
    Inventors: Daniel Kahne, Michael D. Mandler
  • METHODS OF TREATMENT FOR BACTERIAL INFECTIONS
    Publication number: 20220202843
    Abstract: This invention features new compositions and methods that are useful in treating a host with a Gram-negative bacterial infection. Combination therapies comprising an aminocoumarin compound and a polymyxin compound are disclosed, including certain combinations that exhibit synergistic effects. Furthermore, aminocoumarin compounds are described having altered inhibition of DNA gyrase in Gram-negative bacteria and/or the ability to target the transport proteins responsible for assembling lipopolysaccharide in the outer membrane of Gram-negative bacteria.
    Type: Application
    Filed: December 2, 2021
    Publication date: June 30, 2022
    Inventors: Daniel E. Kahne, Michael D. Mandler, Vadim Baidin, Natividad Ruiz
  • Methods of treatment for bacterial infections
    Patent number: 11191773
    Abstract: This invention features new compositions and methods that are useful in treating a host with a Gram-negative bacterial infection. Combination therapies comprising an aminocoumarin compound and a polymyxin compound are disclosed, including certain combinations that exhibit synergistic effects. Furthermore, aminocoumarin compounds are described having altered inhibition of DNA gyrase in Gram-negative bacteria and/or the ability to target the transport proteins responsible for assembling lipopolysaccharide in the outer membrane of Gram-negative bacteria.
    Type: Grant
    Filed: July 16, 2018
    Date of Patent: December 7, 2021
    Assignees: President and Fellows of Harvard College, The Ohio State University
    Inventors: Daniel E. Kahne, Michael D. Mandler, Vadim Baidin, Natividad Ruiz
  • AMINOCOUMARIN COMPOUNDS AND METHODS OF THEIR USE
    Publication number: 20210009621
    Abstract: Disclosed are aminocoumarin compounds, pharmaceutical compositions containing aminocoumarin compounds, and methods of their use, e.g., in the treatment of a Gram-negative bacterial infection.
    Type: Application
    Filed: March 12, 2019
    Publication date: January 14, 2021
    Inventors: Daniel Kahne, Michael D. Mandler
  • METHODS OF TREATMENT FOR BACTERIAL INFECTIONS
    Publication number: 20200163985
    Abstract: This invention features new compositions and methods that are useful in treating a host with a Gram-negative bacterial infection. Combination therapies comprising an aminocoumarin compound and a polymyxin compound are disclosed, including certain combinations that exhibit synergistic effects. Furthermore, aminocoumarin compounds are described having altered inhibition of DNA gyrase in Gram-negative bacteria and/or the ability to target the transport proteins responsible for assembling lipopolysaccharide in the outer membrane of Gram-negative bacteria.
    Type: Application
    Filed: July 16, 2018
    Publication date: May 28, 2020
    Inventors: Daniel E. Kahne, Michael D. Mandler, Vadim Baidin, Natividad Ruiz