Abstract: A method, for enhancing uptake, into a disease site, of therapeutic agent administered to the bloodstream, includes sealing a partial enclosure to the patient at the disease site, administering the therapeutic agent to the bloodstream at a first time, and evacuating air from the partial enclosure to produce a partial vacuum in the partial enclosure at a second time that is after the first time by a first delay. A system, for enhancing uptake, into a disease site, of therapeutic agent administered to the bloodstream, includes a first partial enclosure configured to seal to an exposed surface overlying the disease site, a pump configured to produce a partial vacuum in the first partial enclosure to enhance the uptake of the therapeutic agent, and a control module for controlling delay between delivery of the therapeutic agent to the bloodstream and production of the partial vacuum.

Abstract: A method for enhancing uptake of a therapeutic agent from the bloodstream of a patient into a disease site of the patient includes applying negative pressure to the disease site to form a pressure differential favorable for transport of the therapeutic agent from the bloodstream into the disease site. A system for enhancing uptake of therapeutic agent from the bloodstream of a patient into a disease site of the patient includes (a) a partial enclosure with edge configured to interface with an exposed surface, of the patient and overlying the disease site, to seal the partial enclosure to the exposed surface, and (b) a pump for evacuating air from the partial enclosure to produce a partial vacuum in the partial enclosure, to apply a negative pressure to the disease site so as to enhance uptake of the therapeutic agent into the disease site.

Abstract: A method for enhancing uptake of a therapeutic agent from the bloodstream of a patient into a disease site of the patient includes applying negative pressure to the disease site to form a pressure differential favorable for transport of the therapeutic agent from the bloodstream into the disease site. A system for enhancing uptake of therapeutic agent from the bloodstream of a patient into a disease site of the patient includes (a) a partial enclosure with edge configured to interface with an exposed surface, of the patient and overlying the disease site, to seal the partial enclosure to the exposed surface, and (b) a pump for evacuating air from the partial enclosure to produce a partial vacuum in the partial enclosure, to apply a negative pressure to the disease site so as to enhance uptake of the therapeutic agent into the disease site.