Abstract: The present disclosure relates to compounds of Formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions thereof, useful in the treatment of treating viral infections, for example, coronaviridae infections.

Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

Abstract: A sensor network having a first command center and a first access node, comprising a wireless transceiver, coupled to the command center. The sensor network may also include a plurality of nodes individually comprising a wireless transceiver and a directional antenna, wherein each of the plurality of nodes is successively located in a downlink direction relative to the first access node, and is configured to wirelessly communicate via the directional antenna with at least one node of a first neighbor group in a first direction and at least one node of a second neighbor group in a second direction. In addition, a sensor device is individually coupled to at least one of the nodes, and is configured to provide sensor data for the first command center.

Abstract: A sensor network having a first command center and a first access node, comprising a wireless transceiver, coupled to the command center. The sensor network may also include a plurality of nodes individually comprising a wireless transceiver and a directional antenna, wherein each of the plurality of nodes is successively located in a downlink direction relative to the first access node, and is configured to wirelessly communicate via the directional antenna with at least one node of a first neighbor group in a first direction and at least one node of a second neighbor group in a second direction. In addition, a sensor device is individually coupled to at least one of the nodes, and is configured to provide sensor data for the first command center.

Abstract: A laser device which may be used as an oscillator or amplifier comprising a chamber having a volume formed therein and a gain medium within the volume. The gain medium comprises a solid-state element containing active laser ion within the volume. A cooling fluid flows about the solid-state element and a semiconductor laser diode provides optical pump radiation into the volume of the laser chamber such that laser emission from the device passes through the gain medium and the fluid. The laser device provides the advantages of a solid-state gain medium laser (e.g., diode-pumping, high power density, etc), but enables operation at higher average power and beam quality than would be achievable from a pure solid-state medium.

Abstract: A laser device which may be used as an oscillator or amplifier comprising a chamber having a volume formed therein and a gain medium within the volume. The gain medium comprises solid-state elements containing active laser ion distributed within the volume. A cooling fluid flows about the solid-state elements and a semiconductor laser diode provides optical pump radiation into the volume of the laser chamber such that laser emission from the device passes through the gain medium and the fluid. The laser device provides the advantages of a solid-state gain medium laser (e.g., diode-pumping, high power density, etc), but enables operation at higher average power and beam quality than would be achievable from a pure solid-state medium.

Abstract: A laser device which may be used as an oscillator or amplifier comprising a chamber having a volume formed therein and a gain medium within the volume. The gain medium comprises solid-state elements containing active laser ion distributed within the volume. A cooling fluid flows about the solid-state elements and a semiconductor laser diode provides optical pump radiation into the volume of the laser chamber such that laser emission from the device passes through the gain medium and the fluid. The laser device provides the advantages of a solid-state gain medium laser (e.g., diode-pumping, high power density, etc), but enables operation at higher average power and beam quality than would be achievable from a pure solid-state medium.

Abstract: By tapering the diameter of a flanged barrel laser rod over its length, the maximum trapped path length of a barrel mode can be dramatically reduced, thereby reducing the ability of the trapped spontaneous emission to negatively impact laser performance through amplified spontaneous emission (ASE). Laser rods with polished barrels and flanged end caps have found increasing application in diode array end-pumped laser systems. The polished barrel of the rod serves to confine diode array pump light within the rod. In systems utilizing an end-pumping geometry and such polished barrel laser rods, the pump light that is introduced into one or both ends of the laser rod, is ducted down the length of the rod via the total internal reflections (TIRs) that occur when the light strikes the rod's barrel. A disadvantage of using polished barrel laser rods is that such rods are very susceptible to barrel mode paths that can trap spontaneous emission over long path lengths.

Abstract: A solid-state laser device consists of a gain medium in the shape of a polyhedron. A beam enters the gain medium at one surface of the polyhedron and is reflected internally at one or more surfaces with each reflection occurring in approximate the same plane as the plane of incidence of the incident beam. The beam enters and exits the gain medium at different locations. Pump radiation enters the polyhedron through one or more faces. The laser device may be used as the gain medium for a laser oscillator or a laser amplifier. In one variation, the polyhedron contains an internal core section in which there is no gain material. In another variation, the gain medium further includes one or more surfaces oriented to achieve a 90 degree internal reflection of the beam.

Abstract: A method for removing material via a laser so as to reduce the formation of channels comprising the steps of emitting a laser pulse comprising a pulse energy, a pulse duration, and a fluence towards a surface of a drilling material the fluence of a value sufficient to avoid the formation of a channel in the drilling material at the surface to form a hole comprising a side wall and a bottom, shaping a spatial profile of the laser pulse such that the fluence is substantially uniform across the spatial profile; and emitting at least one subsequent laser pulse having a pulse energy, a pulse duration, and a fluence sufficient to avoid the formation of a channel at the bottom of the hole.

Abstract: A diode pumped, high power (at least 20W), short pulse (up to 2 ps), chirped pulse amplified laser using Yb:YAG as the gain material is employed for material processing. Yb:YAG is used as the gain medium for both a regenerative amplifier and a high power 4-pass amplifier. A single common reflective grating optical device is used to both stretch pulses for amplification purposes and to recompress amplified pulses before being directed to a workpiece.

Abstract: A method and apparatus are provided for increasing the energy of chirped laser pulses to an output in the range 0.001 to over 10 millijoules at a repetition rate 0.010 to 100 kHz by using a two stage optical parametric amplifier utilizing a bulk nonlinear crystal wherein the pump and signal beam size can be independently adjusted in each stage.

Abstract: A system for laser machining includes a laser source for propagating a laser beam toward a target location, and a spatial light modulator having individual controllable elements capable of modifying a phase profile of the laser beam to produce a corresponding irradiance pattern on the target location. The system also includes a controller operably connected to the spatial light modulator for controlling the individual controllable elements. By controlling the individual controllable elements, the phase profile of the laser beam may be modified into a desired phase profile so as to produce a corresponding desired irradiance pattern on the target location capable of performing a machining operation on the target location.

Abstract: A method of imaging an object by generating laser pulses with a short-pulse, high-power laser. When the laser pulse strikes a conductive target, bremsstrahlung radiation is generated such that hard ballistic high-energy electrons are formed to penetrate an object. A detector on the opposite side of the object detects these electrons. Since laser pulses are used to form the hard x-rays, multiple pulses can be used to image an object in motion, such as an exploding or compressing object, by using time gated detectors. Furthermore, the laser pulses can be directed down different tubes using mirrors and filters so that each laser pulse will image a different portion of the object.

Abstract: Methods and apparatus for material modification using laser bursts including appropriately timed laser pulses to enhance material modification. In one implementation, a method for material modification comprises the steps of: providing bursts of laser pulses, wherein each burst comprises at least two laser pulses, wherein each laser pulse has a pulse duration within a range of between approximately 10 ps and 100 ns, wherein a time between each laser pulse of each burst is within a range of between approximately 5 ns and 5 &mgr;s; a time between successive bursts is greater than the time between each laser pulse comprising each burst; and directing the bursts upon a workpiece, wherein an intensity of a primary laser pulse of each burst exceeds a damage threshold of the workpiece.

Abstract: A diode pumped, high power (at least 20W), short pulse (up to 2 ps), chirped pulse amplified laser using Yb:YAG as the gain material is employed for material processing. Yb:YAG is used as the gain medium for both a regenerative amplifier and a high power 4-pass amplifier. A single common reflective grating optical device is used to both stretch pulses for amplification purposes and to recompress amplified pulses before being directed to a workpiece.

Abstract: Methods and apparatus for material modification using laser bursts including appropriately timed laser pulses to enhance material modification. In one implementation, a method for material modification comprises the steps of: providing bursts of laser pulses, wherein each burst comprises at least two laser pulses, wherein each laser pulse has a pulse duration within a range of between approximately 10 ps and 100 ns, wherein a time between each laser pulse of each burst is within a range of between approximately 5 ns and 5 &mgr;s; a time between successive bursts is greater than the time between each laser pulse comprising each burst; and directing the bursts upon a workpiece, wherein an intensity of a primary laser pulse of each burst exceeds a damage threshold of the workpiece.

Abstract: The invention consists of a method for high precision machining (cutting, drilling, sculpting) of metals and alloys. By using pulses of a duration in the range of 10 femtoseconds to 100 picoseconds, extremely precise machining can be achieved with essentially no heat or shock affected zone. Because the pulses are so short, there is negligible thermal conduction beyond the region removed resulting in negligible thermal stress or shock to the material beyond approximately 0.1-1 micron (dependent upon the particular material) from the laser machined surface. Due to the short duration, the high intensity (>1012 W/cm2) associated with the interaction converts the material directly from the solid-state into an ionized plasma. Hydrodynamic expansion of the plasma eliminates the need for any ancillary techniques to remove material and produces extremely high quality machined surfaces with negligible redeposition either within the kerf or on the surface.

Abstract: A laser device and methods of lasing, the laser device comprising a chamber containing a volume formed therein and a gain medium within the volume. The gain medium comprises solid-state portions containing active laser ion suspended within a fluid which exhibits a refractive index which is substantially similar to that of the solid-state portions. In a variation, the gain medium is flowed through the volume, cooled externally of the volume and then flowed back through volume. In preferred form, the solid state portions are either naturally suspended within the fluid or are suspended by flow within the fluid. Thus, laser devices are provided in which the laser and the coolant are homogenized into a single gain medium exhibiting thermal properties of a liquid laser but with solid state gain material in order to produce high energy and high average power.

Abstract: A laser device which may be used as an oscillator or amplifier comprising a chamber having a volume formed therein and a gain medium within the volume. The gain medium comprises solid-state elements containing active laser ion distributed within the volume. A cooling fluid flows about the solid-state elements and a semiconductor laser diode provides optical pump radiation into the volume of the laser chamber such that laser emission from the device passes through the gain medium and the fluid. The laser device provides the advantages of a solid-state gain medium laser (e.g., diode-pumping, high power density, etc), but enables operation at higher average power and beam quality than would be achievable from a pure solid-state medium.