Patents by Inventor Michael D. Pluth

Michael D. Pluth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compound embodiments that release H2S by reaction with a reactive compound and methods of making and using the same
    Patent number: 11078157
    Abstract: Disclosed herein are embodiments of a donor compound that releases H2S by reacting with a reactive compound. The donor compound embodiments described herein can be used to deliver H2S to a subject or a sample and further can be used to administer therapeutic agents. The donor compound embodiments also can facilitate bioconjugation. Methods of making and using the donor compound embodiments also are disclosed.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: August 3, 2021
    Assignee: University of Oregon
    Inventors: Michael D. Pluth, Matthew M. Cerda
  • COMPOUNDS FOR THIOL-TRIGGERED COS AND/OR H2S RELEASE AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20210214368
    Abstract: Disclosed herein are embodiments of a compound that is capable of releasing COS and/or H2S upon reaction with a thiol-containing compound. The compound embodiments also can produce a detectable signal (e.g., a fluorescent signal) substantially concomitantly with COS and/or H2S release and/or can release an active agent, such as a therapeutic agent. Methods of making and using the compound embodiments also are disclosed.
    Type: Application
    Filed: January 30, 2019
    Publication date: July 15, 2021
    Applicant: University of Oregon
    Inventors: Michael D. Pluth, Yu Zhao, Matthew M. Cerda
  • Compound embodiments for hydrogen sulfide production and methods of making and using the same
    Patent number: 11040942
    Abstract: Disclosed herein are embodiments of a donor compound that releases COS and/or CS2, which can be converted to H2S. The donor compound embodiments described herein can be used to deliver H2S to a subject or a sample and further can be used to administer therapeutic agents. Methods of making and using the donor compound embodiments also are disclosed.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: June 22, 2021
    Assignee: University of Oregon
    Inventors: Michael D. Pluth, Yu Zhao
  • Compounds for carbonyl sulfide/carbon disulfide/hydrogen sulfide release and methods of making and using the same
    Patent number: 10725055
    Abstract: Disclosed herein are embodiments of donor compounds that can be used to produce H2S from COS or CS2 released from the donor compounds. In some embodiments, the donor compounds can indirectly produce H2S after being exposed to a reactive component in a triggering event. In other embodiments, the donor compounds can indirectly regenerate H2S after reacting with an H2S analyte. The donor compounds disclosed herein can be used for analytical techniques, disease diagnostics, and/or therapeutic applications. Methods of making and using the donor compounds also are provided herein.
    Type: Grant
    Filed: April 10, 2017
    Date of Patent: July 28, 2020
    Assignee: University of Oregon
    Inventors: Michael D. Pluth, Andrea Steiger, Yu Zhao
  • Compounds for determining the presence of hydrogen sulfide and methods of use
    Patent number: 9664696
    Abstract: Disclosed herein are embodiments of H2S-reactive compounds, or compositions thereof, which can be used to determine the presence of H2S, and in some embodiments quantify H2S. Also disclosed herein are methods of using the H2S-reactive compounds. The methods can use colorimetric, chemiluminescent, or bioluminescent testing methods to determine the presence of and/or amount of H2S in a sample.
    Type: Grant
    Filed: May 30, 2014
    Date of Patent: May 30, 2017
    Assignee: University of Oregon
    Inventors: Michael D. Pluth, T. Spencer Bailey, Leticia A. Montoya, Taylor F. Pearce