Abstract: The present disclosure relates to aerosol delivery devices, methods of producing such devices, and elements of such devices. In some embodiments, the present disclosure provides devices configured for vaporization of an aerosol precursor composition that is contained in a reservoir and transported to a heating element by a liquid transport element. The liquid transport element may include a porous monolith.

Abstract: A building structure comprising a first film and a second film. The first film and the second film are each impregnated with L-Dopa. The building structure further includes regolith bulk material between the first film and the second film.

Abstract: The present disclosure provides systems and methods for assessing a mental state of a subject in a single session or over multiple different sessions, using for example an automated module to present and/or formulate at least one query based in part on one or more target mental states to be assessed. The query may be configured to elicit at least one response from the subject. The query may be transmitted in an audio, visual, and/or textual format to the subject to elicit the response. Data comprising the response from the subject can be received. The data can be processed using one or more individual, joint, or fused models. One or more assessments of the mental state associated with the subject can be generated for the single session, for each of the multiple different sessions, or upon completion of one or more sessions of the multiple different sessions.

Abstract: A system and method for balancing flows of renal replacement fluid is disclosed. The method uses pressure controls and pressure sensing devices to more precisely meter and balance the flow of fresh dialysate and spent dialysate. The balancing system may use one or two balancing devices, such as a balance tube, a tortuous path, or a balance chamber.

Abstract: An aerosol delivery device having a detachable power source is provided. A control body may be coupleable with a cartridge to form an aerosol delivery device. The cartridge may contain an aerosol precursor composition and be equipped with a heating element configured to activate and vaporize components of the aerosol precursor composition. The control body may comprise a housing and a power source detachably coupled to an outer surface of the housing. A control component may be contained within the housing and configured to operate in an active mode in which the control body is coupled with the cartridge. The control component in the active mode may be configured to direct power from the power source to the heating element to activate and vaporize components of the aerosol precursor composition.

Abstract: A marine sonar system comprises a sonar transducer, an attitude sensor, and a processing element. The sonar transducer is configured to transmit a sonar beam into a body of water according to a transmit electronic signal, receive reflections of the sonar beam, and output a receive electronic signal according to the reflections of the sonar beam. The attitude sensor is configured to determine an attitude angle of a marine vessel with which the marine sonar system is utilized and to output an attitude electronic signal whose value varies according to the attitude angle. The processing element configured to receive the attitude electronic signal receive and, based on the attitude electronic signal, control the output of the transmit electronic signal to the sonar transducer.

Abstract: Embodiments disclosed in the present application relate to a composition that can include a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof. Additional embodiments disclosed relate to methods for treating a disease condition such as a hepatitis C virus infection, liver fibrosis and/or impaired liver function with a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof.

Abstract: Embodiments disclosed in the present application relate to a composition that can include a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof. Additional embodiments disclosed relate to methods for treating a disease condition such as a hepatitis C virus infection, liver fibrosis and/or impaired liver function with a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof.

Abstract: A variable resistance device comprises a resistive member having a resistive resilient material. A first conductor is configured to be electrically coupled with the resistive member at a first contact location over a first contact area. A second conductor is configured to be electrically coupled with the resistance member at a second contact location over a second contact area. The first contact location and second contact location are spaced from one another by a distance. The resistance between the first conductor at the first contact location and the second conductor at the second contact location is equal to the sum of a straight resistance component and a parallel path resistance component. At least one of the first location, the second location, the first contact area, and the second contact area is changed to produce a change in resistance between the first conductor and the second conductor.

Abstract: Embodiments disclosed in the present application relate to a composition that can include a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof. Additional embodiments disclosed relate to methods for treating a disease condition such as a hepatitis C virus infection, liver fibrosis and/or impaired liver function with a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof.

Abstract: A variable resistance device comprises a resistive member having a resistive resilient material. A first conductor is configured to be electrically coupled with the resistive member at a first contact location over a first contact area. A second conductor is configured to be electrically coupled with the resistance member at a second contact location over a second contact area. The first contact location and second contact location are spaced from one another by a distance. The resistance between the first conductor at the first contact location and the second conductor at the second contact location is equal to the sum of a straight resistance component and a parallel path resistance component. At least one of the first location, the second location, the first contact area, and the second contact area is changed to produce a change in resistance between the first conductor and the second conductor.

Abstract: A variable resistance device comprises a resistive member having a resistive resilient material. A first conductor is configured to be electrically coupled with the resistive member at a first contact location over a first contact area. A second conductor is configured to be electrically coupled with the resistance member at a second contact location over a second contact area. The first contact location and second contact location are spaced from one another by a distance. The resistance between the first conductor at the first contact location and the second conductor at the second contact location is equal to the sum of a straight resistance component and a parallel path resistance component. At least one of the first location, the second location, the first contact area, and the second contact area is changed to produce a change in resistance between the first conductor and the second conductor.

Abstract: A method of providing a variable resistance from a resistive member including a resistive resilient material comprises electrically coupling a first conductor with the resistive member at a first contact location over a first contact area; and electrically coupling a second conductor with the resistive member at a movable second contact location over a second contact area. The second contact location is movable relative to the resistive member to change the second contact location between the second conductor and the resistive member, the first contact location and the movable second contact location being spaced from one another by a distance.

Abstract: A pointing device comprises a substrate with an electrically conductive surface (36) and a resilient return member (12). The return member resiliently supports a resistive surface (20) to contact the electrically conductive surface (36) in a pressed mode when a force (23) is applied to push and deform the return member against the electrically conductive surface. The return member (12) is made of a resistive rubber material. The resistive surface (20) has a voltage variance and is curved to be rocked on the electrically conductive surface (36) in the pressed mode. The voltage variance is detected on the electrically conductive (20) surface and a variable signal is generated and processed. In a specific embodiment, a dome switch is disposed between the resistive surface and the electrically conductive surface to provide a drag function.

Abstract: Novel compounds, N,N′-bis(phosphonomethyl)-N,N′-bis(hydroxycarbonylmethyl)urea and N,N,N′,N′-tetrakis(hydroxycarbonylmethyl)urea, suitable for use in preparing N-acyl aminocarboxylic acids that can be readily converted to N-(phosphonomethyl)glycine are provided. The compounds may be formed by the reaction of bis-(phosophonomethyl)urea or urea respectively with carbon monoxide and formaldehyde in the presence of a carboxymethylation catalyst precursor and solvent.

Abstract: A pointing device comprises a substrate with an electrically conductive surface and a resilient boot. The resilient boot resiliently supports a resistive surface to contact the electrically conductive surface in a pressed mode when a force is applied to push and deform the resilient boot against the electrically conductive surface. The resilient boot is made of a resistive rubber material. The resistive surface has a voltage variance and is curved to be rocked on the electrically conductive surface in the pressed mode. The voltage variance is detected on the electrically conductive surface and a variable signal is generated and processed. At least one inner switch is provided near the center region of the electrically conductive surface and the inner switch is activated by the resistive surface in the pressed mode. When the force is removed, the resistive resilient boot returns to its undeformed state and the resistive surface is spaced from the electrically conductive surface in a rest mode.

Abstract: A variable resistance device comprises a resistive member having a resistive resilient material. A first conductor is configured to be electrically coupled with the resistive member at a first contact location over a first contact area. A second conductor is configured to be electrically coupled with the resistance member at a second contact location over a second contact area. The first contact location and second contact location are spaced from one another by a distance. The resistance between the first conductor at the first contact location and the second conductor at the second contact location is equal to the sum of a straight resistance component and a parallel path resistance component. At least one of the first location, the second location, the first contact area, and the second contact area is changed to produce a change in resistance between the first conductor and the second conductor.

Abstract: A variable resistance device comprises a resistive member having a resistive rubber material. A first conductor is configured to be electrically coupled with the resistive member at a first contact location over a first contact area. A second conductor is configured to be electrically coupled with the resistance member at a second contact location over a second contact area. The first contact location and second contact location are spaced from one another by a distance. The resistance between the first conductor at the first contact location and the second conductor at the second contact location is equal to the sum of a straight resistance component and a parallel path resistance component. At least one of the first location, the second location, the first contact area, and the second contact area is changed to produce a change in resistance between the first conductor and the second conductor.

Abstract: Novel compounds, N,N′-bis(phosphonomethyl)-N,N′-bis(hydroxycarbonylmethyl)urea and N,N,N′,N′-tetrakis(hydroxycarbonylmethyl)urea, suitable for use in preparing N-acyl aminocarboxylic acids that can be readily converted to N-(phosphonomethyl)glycine are provided. The compounds may be formed by the reaction of bis-(phosophonomethyl)urea or urea respectively with carbon monoxide and formaldehyde in the presence of a carboxymethylation catalyst precursor and solvent.

Abstract: A pointing device comprises a stick coupled to a resilient return member which is supported on a substrate along an outer edge to move relative to an upper substrate surface of the substrate. The upper substrate surface has conductive lines and resistive coatings formed thereon or embedded therein. The return member has a conductive surface which is biased with a voltage and is normally spaced from the upper substrate surface. When an user applies an external force to the stick to move the return member toward the substrate, the conductive surface makes electrical contact with the substrate surface and generates a digital signal. The conductive surface is convex to provide rolling contact with the substrate surface to change the contact location. The conductive surface is deformable to allow the area of contact to increase with an increased external force for a change in resistance.