Abstract: A marine sonar system comprises a sonar transducer, an attitude sensor, and a processing element. The sonar transducer is configured to transmit a sonar beam into a body of water according to a transmit electronic signal, receive reflections of the sonar beam, and output a receive electronic signal according to the reflections of the sonar beam. The attitude sensor is configured to determine an attitude angle of a marine vessel with which the marine sonar system is utilized and to output an attitude electronic signal whose value varies according to the attitude angle. The processing element configured to receive the attitude electronic signal receive and, based on the attitude electronic signal, control the output of the transmit electronic signal to the sonar transducer.

Abstract: Embodiments disclosed in the present application relate to a composition that can include a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof. Additional embodiments disclosed relate to methods for treating a disease condition such as a hepatitis C virus infection, liver fibrosis and/or impaired liver function with a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof.

Abstract: Embodiments disclosed in the present application relate to a composition that can include a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof. Additional embodiments disclosed relate to methods for treating a disease condition such as a hepatitis C virus infection, liver fibrosis and/or impaired liver function with a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof.

Abstract: A variable resistance device comprises a resistive member having a resistive resilient material. A first conductor is configured to be electrically coupled with the resistive member at a first contact location over a first contact area. A second conductor is configured to be electrically coupled with the resistance member at a second contact location over a second contact area. The first contact location and second contact location are spaced from one another by a distance. The resistance between the first conductor at the first contact location and the second conductor at the second contact location is equal to the sum of a straight resistance component and a parallel path resistance component. At least one of the first location, the second location, the first contact area, and the second contact area is changed to produce a change in resistance between the first conductor and the second conductor.

Abstract: Embodiments disclosed in the present application relate to a composition that can include a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof. Additional embodiments disclosed relate to methods for treating a disease condition such as a hepatitis C virus infection, liver fibrosis and/or impaired liver function with a hepatitis C viral polymerase inhibitor, or pharmaceutically acceptable salt or prodrug thereof and a hepatitis C viral protease inhibitor, or pharmaceutically acceptable salt or prodrug thereof.

Abstract: A variable resistance device comprises a resistive member having a resistive resilient material. A first conductor is configured to be electrically coupled with the resistive member at a first contact location over a first contact area. A second conductor is configured to be electrically coupled with the resistance member at a second contact location over a second contact area. The first contact location and second contact location are spaced from one another by a distance. The resistance between the first conductor at the first contact location and the second conductor at the second contact location is equal to the sum of a straight resistance component and a parallel path resistance component. At least one of the first location, the second location, the first contact area, and the second contact area is changed to produce a change in resistance between the first conductor and the second conductor.

Abstract: A variable resistance device comprises a resistive member having a resistive resilient material. A first conductor is configured to be electrically coupled with the resistive member at a first contact location over a first contact area. A second conductor is configured to be electrically coupled with the resistance member at a second contact location over a second contact area. The first contact location and second contact location are spaced from one another by a distance. The resistance between the first conductor at the first contact location and the second conductor at the second contact location is equal to the sum of a straight resistance component and a parallel path resistance component. At least one of the first location, the second location, the first contact area, and the second contact area is changed to produce a change in resistance between the first conductor and the second conductor.

Abstract: A method of providing a variable resistance from a resistive member including a resistive resilient material comprises electrically coupling a first conductor with the resistive member at a first contact location over a first contact area; and electrically coupling a second conductor with the resistive member at a movable second contact location over a second contact area. The second contact location is movable relative to the resistive member to change the second contact location between the second conductor and the resistive member, the first contact location and the movable second contact location being spaced from one another by a distance.

Abstract: A pointing device comprises a substrate with an electrically conductive surface (36) and a resilient return member (12). The return member resiliently supports a resistive surface (20) to contact the electrically conductive surface (36) in a pressed mode when a force (23) is applied to push and deform the return member against the electrically conductive surface. The return member (12) is made of a resistive rubber material. The resistive surface (20) has a voltage variance and is curved to be rocked on the electrically conductive surface (36) in the pressed mode. The voltage variance is detected on the electrically conductive (20) surface and a variable signal is generated and processed. In a specific embodiment, a dome switch is disposed between the resistive surface and the electrically conductive surface to provide a drag function.

Abstract: Novel compounds, N,N′-bis(phosphonomethyl)-N,N′-bis(hydroxycarbonylmethyl)urea and N,N,N′,N′-tetrakis(hydroxycarbonylmethyl)urea, suitable for use in preparing N-acyl aminocarboxylic acids that can be readily converted to N-(phosphonomethyl)glycine are provided. The compounds may be formed by the reaction of bis-(phosophonomethyl)urea or urea respectively with carbon monoxide and formaldehyde in the presence of a carboxymethylation catalyst precursor and solvent.

Abstract: A pointing device comprises a substrate with an electrically conductive surface and a resilient boot. The resilient boot resiliently supports a resistive surface to contact the electrically conductive surface in a pressed mode when a force is applied to push and deform the resilient boot against the electrically conductive surface. The resilient boot is made of a resistive rubber material. The resistive surface has a voltage variance and is curved to be rocked on the electrically conductive surface in the pressed mode. The voltage variance is detected on the electrically conductive surface and a variable signal is generated and processed. At least one inner switch is provided near the center region of the electrically conductive surface and the inner switch is activated by the resistive surface in the pressed mode. When the force is removed, the resistive resilient boot returns to its undeformed state and the resistive surface is spaced from the electrically conductive surface in a rest mode.

Abstract: A variable resistance device comprises a resistive member having a resistive resilient material. A first conductor is configured to be electrically coupled with the resistive member at a first contact location over a first contact area. A second conductor is configured to be electrically coupled with the resistance member at a second contact location over a second contact area. The first contact location and second contact location are spaced from one another by a distance. The resistance between the first conductor at the first contact location and the second conductor at the second contact location is equal to the sum of a straight resistance component and a parallel path resistance component. At least one of the first location, the second location, the first contact area, and the second contact area is changed to produce a change in resistance between the first conductor and the second conductor.

Abstract: A variable resistance device comprises a resistive member having a resistive rubber material. A first conductor is configured to be electrically coupled with the resistive member at a first contact location over a first contact area. A second conductor is configured to be electrically coupled with the resistance member at a second contact location over a second contact area. The first contact location and second contact location are spaced from one another by a distance. The resistance between the first conductor at the first contact location and the second conductor at the second contact location is equal to the sum of a straight resistance component and a parallel path resistance component. At least one of the first location, the second location, the first contact area, and the second contact area is changed to produce a change in resistance between the first conductor and the second conductor.

Abstract: Novel compounds, N,N′-bis(phosphonomethyl)-N,N′-bis(hydroxycarbonylmethyl)urea and N,N,N′,N′-tetrakis(hydroxycarbonylmethyl)urea, suitable for use in preparing N-acyl aminocarboxylic acids that can be readily converted to N-(phosphonomethyl)glycine are provided. The compounds may be formed by the reaction of bis-(phosophonomethyl)urea or urea respectively with carbon monoxide and formaldehyde in the presence of a carboxymethylation catalyst precursor and solvent.

Abstract: A pointing device comprises a stick coupled to a resilient return member which is supported on a substrate along an outer edge to move relative to an upper substrate surface of the substrate. The upper substrate surface has conductive lines and resistive coatings formed thereon or embedded therein. The return member has a conductive surface which is biased with a voltage and is normally spaced from the upper substrate surface. When an user applies an external force to the stick to move the return member toward the substrate, the conductive surface makes electrical contact with the substrate surface and generates a digital signal. The conductive surface is convex to provide rolling contact with the substrate surface to change the contact location. The conductive surface is deformable to allow the area of contact to increase with an increased external force for a change in resistance.

Abstract: A process for the continuous production of N-(phosphonomethyl)glycine is provided. In the process, N-(acetyl)iminodiacetic acid is formed in an amidocarboxymethylation reactor system. The N-(acetyl)iminodiacetic acid product stream is either: (1) reacted with a source of phosphorous and a source of formaldehyde in the presence of an acid to form a phosphonomethylation reaction product stream containing N-(phosphonomethyl)iminodiacetic acid and acetic acid; or (2) deacylated and cyclized to form a 2,5-diketopiperazine, and then reacted with a source of phosphorous and a source of formaldehyde in the presence of an acid to form a phosphonomethylation reaction product stream containing N-(phosphonomethyl)iminodiacetic acid and acetic acid. In either case, the N-(phosphonomethyl)iminodiacetic acid product is recovered and converted to N-(phosphonomethyl)glycine.

Abstract: Novel compounds, N,N′-bis(phosphonomethyl)-N,N′-bis(hydroxycarbonylmethyl)urea and N,N,N′,N′-tetrakis(hydroxycarbonylmethyl)urea, suitable for use in preparing N-acyl aminocarboxylic acids that can be readily converted to N-(phosphonomethyl)glycine are provided. The compounds may be formed by the reaction of bis-(phosophonomethyl)urea or urea respectively with carbon monoxide and formaldehyde in the presence of a carboxymethylation catalyst precursor and solvent.

Abstract: An ergonomic pointing device comprises an orb controller coupled to a resilient return member which is supported on a substrate to move relative to an upper substrate surface of the substrate. The substrate surface has conductive lines and resistive coatings formed thereon or embedded therein. The return member has a conductive surface which is biased with a voltage and is spaced from the substrate surface at rest. When a user applies an external force to the orb controller to move the return member toward the substrate, the conductive surface makes electrical contact with the substrate surface and generates a digital signal. The conductive surface is convex to provide rolling contact with the substrate surface to change the contact location. The orb controller has a curved control surface which is contacted by a digit of a human hand to manipulate movement of the conductive surface relative to the substrate surface. The orb controller has a substantially smaller height than a joystick.

Abstract: A pointing device comprises a substrate with an electrically conductive surface and a resilient boot. The resilient boot resiliently supports a resistive surface to contact the electrically conductive surface in a pressed mode when a force is applied to push and deform the resilient boot against the electrically conductive surface. The resilient boot is made of a resistive rubber material. The resistive surface has a voltage variance and is curved to be rocked on the electrically conductive surface in the pressed mode. The voltage variance is detected on the electrically conductive surface and a variable signal is generated and processed. At least one inner switch is provided near the center region of the electrically conductive surface and the inner switch is activated by the resistive surface in the pressed mode. When the force is removed, the resistive resilient boot returns to its undeformed state and the resistive surface is spaced from the electrically conductive surface in a rest mode.

Abstract: Process for the preparation of an N-acyl amino carboxylic acid by means of a carboxymethylation reaction. In this reaction, a reaction mixture is formed which contains a base pair, carbon monoxide, hydrogen and an aldehyde with the base pair comprising a carbamoyl compound and a carboxymethylation catalyst precursor. In a preferred embodiment, the carbamoyl compound and aldehyde are selected to yield an N-acyl amino carboxylic acid which is readily converted to N-(phosphonomethyl)glycine, or a salt or ester thereof.