Patents by Inventor Michael D. Ruff

Michael D. Ruff has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Coated dibasic calcium phosphate
    Publication number: 20040091544
    Abstract: An oral formulation containing an active pharmaceutical ingredient, for instance a peptide pharmaceutical, such as insulin, coated onto a suitable particulate substrate, such as dibasic calcium phosphate. The oral formulation may be a modified release formulation, for instance a controlled release formulation or a sustained release formulation, or may be an immediate release formulation. Also, the formulation may be encapsulated in gelatin capsules or may be compressed into tablets.
    Type: Application
    Filed: August 19, 2003
    Publication date: May 13, 2004
    Inventors: Michael D. Ruff, Joseph E. Cobb
  • Stabilized pharmaceutical
    Patent number: 5763493
    Abstract: This application discloses a method of inhibiting degradation of the antidepressant bupropion hydrochloride in a solid pharmaceutical formulation, so that the pharmaceutical formulation will maintain at least 80% of its initial bupropion potency after one year.
    Type: Grant
    Filed: June 21, 1996
    Date of Patent: June 9, 1998
    Assignee: Glaxo Wellcome Inc.
    Inventors: Michael D. Ruff, Sanvasi R. Kalidindi, Joel Elmore Sutton, Jr.
  • Isolated protein from Eimeria useful as a cross species vaccine
    Patent number: 5709862
    Abstract: A cloned gene or fragment thereof encodes antigenic proteins that bind with a monoclonal or polyvalent antibody that is directed against an antigenic protein of avian coccidia.
    Type: Grant
    Filed: November 8, 1993
    Date of Patent: January 20, 1998
    Assignees: British Technology Group USA Inc., The United States of America as represented by the Department of Agriculture
    Inventors: David M. Anderson, Russell J. McCandliss, Susan Lee Strausberg, Robert L. Strausberg, Michael D. Ruff, Harry D. Danforth, Patricia C. Augustine
  • Eimeria antigenic composition which elicits antibodies against avian coccidiosis
    Patent number: 5656485
    Abstract: This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.
    Type: Grant
    Filed: August 2, 1996
    Date of Patent: August 12, 1997
    Assignee: BTG USA Inc.
    Inventors: James W. Jacobson, Robert L. Strausberg, Susan D. Wilson, Sharon H. Pope, Susan Lee Strausberg, Michael D. Ruff, Patricia C. Augustine, Harry D. Danforth
  • Eimeria antigenic composition which elicits antibodies against avian coccidiosis
    Patent number: 5597571
    Abstract: This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 28, 1997
    Assignee: British Technology Group USA Inc.
    Inventors: James W. Jacobson, Robert L. Strausberg, Susan D. Wilson, Sharon H. Pope, Susan L. Strausberg, Michael D. Ruff, Patricia C. Augustine, Harry D. Danforth
  • Stabilized Pharmaceutical
    Patent number: 5541231
    Abstract: This application discloses a method of inhibiting degradation of the antidepressant bupropion hydrochloride in a solid pharmaceutical formulation, so that the pharmaceutical formulation will maintain at least 80% of its initial bupropion potency after one year.
    Type: Grant
    Filed: August 25, 1994
    Date of Patent: July 30, 1996
    Assignee: Glaxo Wellcome Inc.
    Inventors: Michael D. Ruff, Sanvasi R. Kalidindi, Joel E. Sutton, Jr.
  • Eimeria antigenic composition which elicits antibodies against avian coccidiosis
    Patent number: 5482709
    Abstract: This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.
    Type: Grant
    Filed: November 8, 1993
    Date of Patent: January 9, 1996
    Assignees: British Technology Group USA Inc., The United States of America as represented by the Dept. of Agriculture
    Inventors: James W. Jacobson, Robert L. Strausberg, Susan D. Wilson, Sharon H. Pope, Susan L. Strausberg, Michael D. Ruff, Patricia C. Augustine, Harry D. Danforth
  • Pharmaceutical composition containing bupropion hydrochloride and a stabilizer
    Patent number: 5358970
    Abstract: This application discloses a method of inhibiting degradation of the antidepressant bupropion hydrochloride in a solid pharmaceutical formulation, so that the pharmaceutical formulation will maintain at least 80% of its initial bupropion potency after one year.
    Type: Grant
    Filed: August 12, 1993
    Date of Patent: October 25, 1994
    Assignee: Burroughs Wellcome Co.
    Inventors: Michael D. Ruff, Sanyasi R. Kalidindi, Joel E. Sutton, Jr.
  • 25 KD coccidial antigen of eimeria tenella
    Patent number: 5279960
    Abstract: A cloned gene or fragment thereof encodes antigenic proteins that bind with a monoclonal or polyvalent antibody that is directed against an antigenic protein of avian coccidia.
    Type: Grant
    Filed: May 5, 1992
    Date of Patent: January 18, 1994
    Assignees: Enzon Corp., U.S.A. Dept. of Agriculture
    Inventors: David M. Anderson, Russell J. McCandliss, Susan L. Strausberg, Robert L. Strausberg, Michael D. Ruff, Harry D. Danforth, Patricia C. Augustine
  • Genetically engineered coccidiosis sporozoite 21.5 Kb antigen, ac-6b
    Patent number: 5273901
    Abstract: This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.
    Type: Grant
    Filed: September 12, 1990
    Date of Patent: December 28, 1993
    Assignees: Enzon Corp., U.S. Dept. of Agriculture
    Inventors: James W. Jacobson, Robert L. Strausberg, Susan D. Wilson, Sharon H. Pope, Susan L. Strausberg, Michael D. Ruff, Patricia C. Augustine, Harry D. Danforth
  • Cloned genes coding for avian coccidiosis antigens which induce a cell-mediated immune response
    Patent number: 5122471
    Abstract: Disclosed are DnA sequences which code for antigenic proteins, methods for identifying such DNA sequences, and antigens coded for by such DNA sequences.The first step of the method is to provide a multiplicity of DNA sequences. These sequences are then inserted into DNA expression vectors to form recombinant expression vectors. The expression vectors are inserted into suitable hosts to form transformants which express the DNA sequences. The transformants are then contacted with antibodies directed against Eimeria antigens to identify transformants containing DNA sequences which code for Eimeria antigens. These antigens are then produced from the DNA sequences identified as coding for the antigens. The antigens so produced are contacted with white blood cells which effect a cell-mediated immune response, which white blood cells are sensitized to an antigenic Eimeria protein, to thereby identify DNA sequences which code for antigens that induce a cell-mediated immune response to avian coccidiosis.
    Type: Grant
    Filed: February 9, 1989
    Date of Patent: June 16, 1992
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Mark C. Jenkins, Hyun S. Lillehoj, John B. Dame, Harry D. Danforth, Michael D. Ruff