Abstract: The present disclosure provides pyrimidine dione compounds of Formula I and pharmaceutical compositions thereof, for treating cancer, including solid tumors either-used alone or in combination with other anti-cancer agents.

Abstract: Compounds and methods of using said compounds, singly or in combination with additional agents, and pharmaceutical compositions of said compounds for the treatment of viral infections are disclosed.

Abstract: A system for querying disparate, heterogeneous data sources over a network, where at least some of the data sources are World Wide Web pages or other semi-structured data sources, includes a query converter, a command transmitter, and a data retriever. The query converter produces, from at least a portion of a query, a set of commands which can be used to interact with a semi-structured data source. The query converter may accept a request in the same form as normally used to access a relational data base, therefore increasing the number of data bases available to a user in a transparent manner. The command transmitter issues the produced commands to the semi-structured data source. The data retriever then retrieves the desired data from the data source. In this manner, structured queries may be used to access both traditional, relational data bases as well as non-traditional semi-structured data bases such as web sites and flat files.

Abstract: A system for querying disparate, heterogeneous data sources over a network includes a request translator and a data translator. The request translator translates a request having an associated data context declared by the requester into a query having a second data context associated with it. The second context is also associated with, and is declared by, at least one of the disparate data sources. This system also includes a data translator, which translates received data from the data context declared by the data source queried into the data context associated with the request.

Abstract: A system for querying disparate, heterogeneous data sources over a network, where at least some of the data sources are World Wide Web pages or other semi-structured data sources, includes a query converter, a command transmitter, and a data retriever. The query converter produces, from at least a portion of a query, a set of commands which can be used to interact with a semi-structured data source. The query converter may accept a request in the same form as normally used to access a relational data base, therefore increasing the number of data bases available to a user in a transparent manner. The command transmitter issues the produced commands to the semi-structured data source. The data retriever then retrieves the desired data from the data source. In this manner, structured queries may be used to access both traditional, relational data bases as well as non-traditional, semi-structured data bases such as web sites and flat files.