Patents by Inventor Michael D. Tufano

Michael D. Tufano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-viral compounds
    Patent number: 7763731
    Abstract: Compounds effective in inhibiting replication of Hepatitis C virus (“HCV”) or other viruses are disclosed. This invention is also directed to compositions comprising such compounds, co-formulation or co-administration of such compounds with other anti-viral or therapeutic agents, processes and intermediates for the syntheses of such compounds, and methods of using such compounds for the treatment of HCV or other viral infections.
    Type: Grant
    Filed: December 20, 2006
    Date of Patent: July 27, 2010
    Assignee: Abbott Laboratories
    Inventors: Todd W. Rockway, David A. Betebenner, Allan C. Krueger, Nobuhiko Iwasaki, Curt S. Cooper, David D. Anderson, Dale J. Kempf, Darold L. Madigan, Christopher E. Motter, Jason P. Shanley, Michael D. Tufano, Rolf Wagner, Rong Zhang, Akhteruzzaman Molla, Hongmei Mo, Tami J. Pilot-Matias, Sherie VL. Masse, Robert J. Carrick, Wenping He, Liangjun Lu
  • Peptide analog type-B CCK receptor ligands
    Patent number: 5340802
    Abstract: Peptide analog type-B CCK receptor ligands or pharmaceutically-acceptable salts thereof, which are useful for treating central nervous system disorders, substance abuse, gastrointestinal disorders, endocrine disorders, eating-related disorders and for the treatment of shock, respiratory and cardiocirculatory insufficiencies.
    Type: Grant
    Filed: January 29, 1993
    Date of Patent: August 23, 1994
    Assignee: Abbott Laboratories
    Inventors: Kazumi Shiosaki, Alex M. Nadzan, David S. Garvey, Youe-Kong Shue, Mark S. Brodie, Mark W. Holladay, John Y.-L. Chung, Michael D. Tufano, Paul D. May
  • Chiral supports for resolution of racemates
    Patent number: 4318820
    Abstract: An inorganic oxide impregnated with poly(aminostyrene) whose amino groups are covalently bonded to carboxyl groups of chiral organic hydroxy acids may be used as the solid stationary phase in the chromatographic separation of racemic mixtures.
    Type: Grant
    Filed: February 25, 1980
    Date of Patent: March 9, 1982
    Assignee: UOP Inc.
    Inventors: Thomas P. Malloy, Michael D. Tufano
  • Chiral supports for resolution of racemates
    Patent number: 4318819
    Abstract: Material which can be utilized as the stationary phase in liquid-solid chromatography for the resolution of racemic mixtures comprises an inorganic oxide silylated with a reagent whose remaining terminus is covalently bonded to a chiral hydroxy acid. For example, a 3-aminopropylsilylated silica gel may be reacted with a chiral tartaric anhydride to form a carboxamide linkage by which the chiral acid is covalently bound to the support.
    Type: Grant
    Filed: February 25, 1980
    Date of Patent: March 9, 1982
    Assignee: UOP Inc.
    Inventors: Thomas P. Malloy, Michael D. Tufano
  • Preparation of p-aminodiphenylamines
    Patent number: 4313002
    Abstract: A method of preparing p-aminodiphenylamines from diphenylamines is described whereby neither the N-nitrosodiphenylamine or the p-nitrosodiphenylamine need be isolated. The method rests on the discovery that alkali metal salts of p-nitrosodiphenylamines are soluble in non-aqueous organic solvent systems consisting of certain aromatic hydrocarbons and saturated aliphatic alcohols, and that such salts can be readily hydrogenated in their non-aqueous solution to the corresponding p-aminodiphenylamine.
    Type: Grant
    Filed: October 29, 1980
    Date of Patent: January 26, 1982
    Assignee: UOP Inc.
    Inventors: Ted Symon, Paul R. Kurek, Michael D. Tufano
  • Preparation of nitro-substituted diphenyl ethers
    Patent number: 4287372
    Abstract: A method of preparing nitro-substituted diphenyl ethers comprises contacting a salt of a phenol with a nitro-substituted halobenzene in the presence of a phase-transfer reagent under reaction conditions and recovering the reaction product.
    Type: Grant
    Filed: October 11, 1979
    Date of Patent: September 1, 1981
    Assignee: UOP Inc.
    Inventor: Michael D. Tufano