Abstract: Multi-phase oral care compositions for whitening teeth including hydrophilic bleaching agent particles in a hydrophobic phase with a cone penetration consistency value of from about 25 to about 300. The hydrophilic bleaching agent particles can include peroxide compounds and/or hydrogen peroxide adducts. The hydrophilic bleaching agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water.

Abstract: Semisolid oral dispersions for whitening teeth comprising a hydrophilic discontinuous phase and a hydrophobic continuous phase. The semisolid oral dispersions include a hydrophilic discontinuous phase comprising bleaching agent particles. The semisolid oral dispersions also include a hydrophobic continuous phase comprising petrolatum. The h bleaching agent particles can include peroxide compounds and/or hydrogen peroxide adducts. The bleaching agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water.

Abstract: Multi-phase oral care compositions for whitening teeth, including hydrophilic bleaching agent particles in a hydrophobic phase with a melting point of from about 40° C. to about 80° C. The hydrophilic bleaching agent particles can include peroxide compounds and/or hydrogen peroxide adducts. The hydrophilic bleaching agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water.

Abstract: Semisolid oral dispersions for whitening teeth including hydrogen peroxide adducts in petrolatum. The hydrogen peroxide adduct can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water. The semisolid oral dispersion and/or the petrolatum can have a cone penetration consistency value of from about 25 to about 300.

Abstract: An applicator device for the application of hydrophobic compositions to hydrophilic surfaces. An applicator device for the application of an emulsion composition to wetted teeth. An applicator tip with at least one external ridge, a plurality of internal ridges, and a plurality of internal channels between the plurality of internal ridges.

Abstract: A kit for the application of hydrophobic compositions to hydrophilic surfaces with an applicator device and a container for the hydrophobic composition. An applicator device for the application of an emulsion composition to wetted teeth. An applicator tip with at least one external ridge, a plurality of internal ridges, and a plurality of internal channels between the plurality of internal ridges. A container with a ribbon orifice for the dispensing of the emulsion composition.

Abstract: Multi-phase oral care compositions for whitening teeth. including hydrophilic bleaching agent particles in a hydrophobic phase with a melting point of from about 40° C. to about 80° C. The hydrophilic bleaching agent particles can include peroxide compounds and/or hydrogen peroxide adducts. The hydrophilic bleaching agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water.

Abstract: The semisolid oral dispersions include hydrophilic active agent particles in hydrophobic phase. The hydrophilic active agent particles can include bleaching agents, antimicrobial agents, anticalculus agents, and/or combinations thereof. The hydrophilic active agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water.

Abstract: Multi-phase oral care compositions for whitening teeth. including hydrophilic bleaching agent particles in a hydrophobic phase with a melting point of from about 40° C. to about 80° C. The hydrophilic bleaching agent particles can include peroxide compounds and/or hydrogen peroxide adducts. The hydrophilic bleaching agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water.

Abstract: Semisolid oral dispersions for whitening teeth. The semisolid oral dispersions include hydrophilic bleaching agent particles in a hydrophobic phase. The hydrophilic bleaching agent particles can include peroxide compounds and/or hydrogen peroxide adducts. The hydrophilic bleaching agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water.

Abstract: Semisolid oral dispersions for improving the health and/or appearance of the oral cavity. The semisolid oral dispersions include hydrophilic active agent particles in hydrophobic phase. The hydrophilic active agent particles can include bleaching agents, antimicrobial agents, anticalculus agents, and/or combinations thereof. The hydrophilic active agent particle can have a solubility in water of at least about 20 parts, by weight of the particles, in about 100 parts, by weight, of water.

Abstract: An oral care composition with one or more polyphosphates with about 20 wt % or more of water at a pH of about 5 or less. A dentifrice composition with one or more polyphosphates with about 20 wt % or more of water at a pH of about 5 or less. A mouth rinse composition with one or more polyphosphates with about 20 wt % or more of water at a pH of about 5 or less.

Abstract: A system and method of determining biomechanical properties of a cell. A cell is introduced into a multiport flow device, the device being configured such that during fluid flow at least one stagnation zone arises in an expected location within the device. The cell is trapped in the stagnation zone of the device. A selected physical stimulus is applied to the cell, such as rotation, stretching or time-varying shear rate. The cell is observed while trapped to detect an absolute, differential and/or transient effect of the applied physical stimulus and to thereby determine biomechanical properties of the cell. Disease diagnosis may follow, by comparison to a normal control. Selectively directing the cell to a chosen outlet based on observed properties provides cell sorting, which may be implemented in parallel to increase throughput and/or in series to enlarge sorting criteria. Micro-particles may be investigated by use of appropriate particle model.

Abstract: 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile substantially free of 2,3,7-triamino-4,6-dimethyl-1,9-phenazinedicarbonitrile, and the anhydrous monoacetate salt thereof, are useful in the treatment of alpha-2 mediated disorders such as ocular hypertension.

Abstract: 6-[(4,5-Dihydro-1H-imidazol-2-yl)amino-]-7-methyl-1H-benzimidazole-4-carbonitrile substantially free of 2,3,7-triamino-4,6-dimethyl-1,9-phenazinedicarbonitrile, and the anhydrous monoacetate salt thereof, are useful in the treatment of alpha-2 mediated disorders such as ocular hypertension.