Abstract: Compounds that slow the ATP-hydrolysing mode of ATP synthase are useful for treating various diseases and disorders including cancer, particularly cancers that utilise the Warburg effect.

Abstract: Biomarkers of cancer susceptibility/resistance to almitrine treatment are disclosed.

Abstract: Hypoxemia is an abnormally low O2 concentration in the blood. It can be lethal. When vital organs don't get enough O2 to operate properly. A coronavirus infection can cause hypoxemia. Wherein this is probably the most common cause of coronavirus associated death. COVID-19 has killed millions of people to date. A method comprising the administration of a therapeutically effective amount of almitrine dimesylate to a subject with a coronavirus infection. To treat/ameliorate/reduce/prevent any coronavirus associated hypoxemia in the subject. Therein increasing the subject's chance of survival.

Abstract: Compounds of the following formula (I) slow the ATP-hydrolysing mode of ATP synthase and are useful for treating various diseases and disorders including cancer, particularly cancers that utilise the Warburg effect.

Abstract: Compounds of the following formula, and pharmaceutically-acceptable salts, solvates, hydrates and prodrugs thereof, formula (A) are useful to preferentially inhibit the ATP-hydrolysing mode of ATP synthase, and are thereby useful for treating various diseases and orders including cancer, particularly cancers that utilise the Warburg effect.