Abstract: Methods and systems are provided for small molecule analyte detection using digital signals, key encryption, and communications protocols. The methods provide detection of a large numbers of proteins, peptides, RNA molecules, and DNA molecules in a single optical or electrical detection assay within a large dynamic range.

Abstract: Disclosed herein are methods and systems for detection and discrimination of optical signals from a densely packed substrate. These have broad applications for biomolecule detection near or below the diffraction limit of optical systems, including in improving the efficiency and accuracy of polynucleotide sequencing applications.

Abstract: Methods are provided for detecting a single compound analyte immobilized to a solid substrate by serially contacting and removing different probes to the same analyte.

Abstract: Electrical detection methods are used to identify and further characterize single-molecule target analytes such as proteins and nucleic acids. A composition including a probe region and a tail region is contacted with a target analyte. The probe region specifically binds to the target analyte. The tail region is coupled to the probe region, and includes a nucleic acid template for polynucleotide synthesis. When conditions are such that polynucleotide synthesis occurs along the tail region, one hydrogen ion is released for every nucleotide that is incorporated into the tail region. A transistor such as an ISFET detects and measures changes in ion concentration, and these measurements can be used to identify the tail region and thus characterize the corresponding target analyte.

Abstract: Electrical detection methods are used to identify and further characterize single-molecule target analytes such as proteins and nucleic acids. A composition including a probe region and a tail region is contacted with a target analyte. The probe region specifically binds to the target analyte. The tail region is coupled to the probe region, and includes a nucleic acid template for polynucleotide synthesis. When conditions are such that polynucleotide synthesis occurs along the tail region, one hydrogen ion is released for every nucleotide that is incorporated into the tail region. A transistor such as an ISFET detects and measures changes in ion concentration, and these measurements can be used to identify the tail region and thus characterize the corresponding target analyte.

Abstract: Methods are provided for detecting a single compound analyte immobilized to a solid substrate by serially contacting and removing different probes to the same analyte.

Abstract: Electrical detection methods are used to identify and further characterize single-molecule target analytes such as proteins and nucleic acids. A composition including a probe region and a tail region is contacted with a target analyte. The probe region specifically binds to the target analyte. The tail region is coupled to the probe region, and includes a nucleic acid template for polynucleotide synthesis. When conditions are such that polynucleotide synthesis occurs along the tail region, one hydrogen ion is released for every nucleotide that is incorporated into the tail region. A transistor such as an ISFET detects and measures changes in ion concentration, and these measurements can be used to identify the tail region and thus characterize the corresponding target analyte.

Abstract: Disclosed herein are methods and systems for detection and discrimination of optical signals from a densely packed substrate. These have broad applications for biomolecule detection near or below the diffraction limit of optical systems, including in improving the efficiency and accuracy of polynucleotide sequencing applications.

Abstract: Electrical detection methods are used to identify and further characterize single-molecule target analytes such as proteins and nucleic acids. A composition including a probe region and a tail region is contacted with a target analyte. The probe region specifically binds to the target analyte. The tail region is coupled to the probe region, and includes a nucleic acid template for polynucleotide synthesis. When conditions are such that polynucleotide synthesis occurs along the tail region, one hydrogen ion is released for every nucleotide that is incorporated into the tail region. A transistor such as an ISFET detects and measures changes in ion concentration, and these measurements can be used to identify the tail region and thus characterize the corresponding target analyte.

Abstract: Disclosed herein are methods and systems for detection and discrimination of optical signals from a densely packed substrate. These have broad applications for biomolecule detection near or below the diffraction limit of optical systems, including in improving the efficiency and accuracy of polynucleotide sequencing applications.

Abstract: Methods and systems are provided for small molecule analyte detection using digital signals, key encryption, and communications protocols. The methods provide detection of a large numbers of proteins, peptides, RNA molecules, and DNA molecules in a single optical or electrical detection assay within a large dynamic range.

Abstract: Disclosed herein are methods and systems for detection and discrimination of optical signals from a densely packed substrate. These have broad applications for biomolecule detection near or below the diffraction limit of optical systems, including in improving the efficiency and accuracy of polynucleotide sequencing applications.

Abstract: In one aspect, a device includes at least one processor, a display accessible to the at least one processor, and storage accessible to the at least one processor. The storage includes instructions executable by the at least one processor to present an image of an object on the display, and present a graphical user interface (GUI) on the display with the GUI indicating the object. The instructions are also executable by the processor to present, on the GUI, at least one link to content that an end-user may associate with the object or that an end-user has associated with the object.

Abstract: A method, electronic device, and accessory for carrying out functions based on reflected electromagnetic radiation are provided. According to one implementation, an electronic device transmits electromagnetic radiation (“EMR”) to an accessory and detects a reflection of the transmitted EMR off of the accessory. A characteristic of the reflected EMR maps to a predetermined function associated with the accessory, which the electronic device performs.

Abstract: An electronic device includes an analog connector and a digital connector. The analog connector has one or more analog signal contacts and at least one other contact. A signal detector detects signals at the other contact. A switch is coupled to the other contact to, where analog signals are at the other contact, to cause the switch to transition a connection to other contact from a common node of the device to a signal node of the device, thereby allowing a user to use either a four-wire accessory device or five-wire accessory device with a four-wire analog connector.

Abstract: In a first embodiment, a method includes: entering a reduced communications performance environment, wherein a mobile device connected to a network loses connection to the network; attempting to reconnect to the network in the reduced performance environment without success; recording network connection attempt information; entering an improved performance environment, wherein the mobile device is reconnected to the network; and transmitting the network connection attempt information to a remote server. In a second embodiment, a method includes: consulting a network reconnection attempts profile previously sent from a cloud server to a mobile device; based on the network reconnections attempts profile, determining a network reconnection attempt schedule; and attempting to reconnect to the network according to the network reconnection attempt schedule until the mobile device is reconnected to the network.

Abstract: In a first embodiment, a method includes: entering a reduced communications performance environment, wherein a mobile device connected to a network loses connection to the network; attempting to reconnect to the network in the reduced performance environment without success; recording network connection attempt information; entering an improved performance environment, wherein the mobile device is reconnected to the network; and transmitting the network connection attempt information to a remote server. In a second embodiment, a method includes: consulting a network reconnection attempts profile previously sent from a cloud server to a mobile device; based on the network reconnections attempts profile, determining a network reconnection attempt schedule; and attempting to reconnect to the network according to the network reconnection attempt schedule until the mobile device is reconnected to the network.

Abstract: A method, electronic device, and accessory for carrying out functions based on reflected electromagnetic radiation are provided. According to one implementation, an electronic device transmits electromagnetic radiation (“EMR”) to an accessory and detects a reflection of the transmitted EMR off of the accessory. A characteristic of the reflected EMR maps to a predetermined function associated with the accessory, which the electronic device performs.

Abstract: This disclosure is generally directed to a method for correcting the perspective of an image. According to various embodiments, the method, which is carried out on an electronic device having a display, involves mapping logical pixels of the image to physical pixels of the display based on the expected viewing angle of the location (e.g., the screen location) of the display at which the logical pixels are to be rendered. The effect of this mapping, according to various embodiments, is to make the apparent size of certain portions of the image larger in order to correct for perspective distortion caused by the viewing angle at which the image is viewed.

Abstract: Methods and systems are provided for small molecule analyte detection using digital signals, key encryption, and communications protocols. The methods provide detection of a large numbers of proteins, peptides, RNA molecules, and DNA molecules in a single optical or electrical detection assay within a large dynamic range.