Abstract: This disclosure relates to combination therapies targeting two or all of PD-1, TIM-3, and LAG-3 using antibodies specific for these targets in patients who are in need of enhanced immunity. Also included in the disclosure are compositions useful in the therapies. The therapies are useful in treating diseases such as cancers.

Abstract: Creating genetic devices for use in micro-organisms or other biological systems is described. In an embodiment a computer system receives at a program editor, input specifying a plurality of part designs, at least some of which comprise part properties expressed as logical variables; and the input also specifies constraints on the logical variables. For example, the input is a computer program which specifies constraints on the logical variables which, for example, relate to properties of the DNA sequences such as reactions and biological behaviors. In an example, a compiler resolves the constraints using a database of genetic parts in order to generate candidate parts for the proposed genetic device. In examples the sequences of genetic parts are translated into reactions and simulated using an automated simulator and/or implemented in a living cell or other biological system. In embodiments the compiler also uses a database of reactions.

Abstract: A method of operating a device includes sending to a server system a request for data relating to a particular number of elements in the vicinity of a location of the device, receiving a response with data relating to a set of elements, the data including data specifying a location associated with each of the elements, causing a user interface to provide an output representing data related to one or more of the elements, wherein the configuration of the output is dependent upon the location of the elements relative to the location of the device, and in response to a change in the location of the device, updating the output using the data in the response. A device is shown carrying out the method as well as a system including the device and a server.

Abstract: A system (1) includes a plurality of mobile devices (21 . . . 2N) connectable to a server system (3) via a network system (4), one or more computing devices (5) connectable to the server system (3). The system (1) also includes a global navigation satellite system (36) and a plurality of transmitters (371 . . . 37N?). For example, the system can be for providing location-based and/or social networking services to users of the mobile devices (21 . . . 2N). Improvements in aspects of the underlying technology are described.

Abstract: A system (1) includes a plurality of mobile devices (21 . . . 2N) connectable to a server system (3) via a network system (4), one or more computing devices (5) connectable to the server system (3). The system (1) also includes a global navigation satellite system (36) and a plurality of transmitters (371 . . . 37N?). For example, the system can be for providing location-based and/or social networking services to users of the mobile devices (21 . . . 2N). Improvements in aspects of the underlying technology are described.

Abstract: Creating genetic devices for use in micro-organisms or other biological systems is described. In an embodiment a computer system receives at a program editor, input specifying a plurality of part designs, at least some of which comprise part properties expressed as logical variables; and the input also specifies constraints on the logical variables. For example, the input is a computer program which specifies constraints on the logical variables which, for example, relate to properties of the DNA sequences such as reactions and biological behaviors. In an example, a compiler resolves the constraints using a database of genetic parts in order to generate candidate parts for the proposed genetic device. In examples the sequences of genetic parts are translated into reactions and simulated using an automated simulator and/or implemented in a living cell or other biological system. In embodiments the compiler also uses a database of reactions.