Patents by Inventor Michael David Thomas

Michael David Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250179528
    Abstract: The present invention relates to nucleobase editing complexes comprising a) a catalytically inactive RNA-guided endonuclease having a sequence identity of at least 60% to SEQ ID NO: 126 or SEQ ID NO: 155 and b) a nucleobase editing domain, as well as polynucleotides encoding said nucleobase editing complexes, nucleic acid constructs and expression vectors comprising said polynucleotides, host cells comprising said nucleobase editing complexes and/or polynucleotides, and methods for preparing and using said nucleobase editing complexes.
    Type: Application
    Filed: March 10, 2021
    Publication date: June 5, 2025
    Applicant: Novozymes A/S
    Inventors: Takashi Nakanishi, Michael David Thomas
  • Patent number: 7440610
    Abstract: An embodiment of the present invention utilizes the Precision Strike Suite (PSS). PSS performs tasks including but not limited to the generation of true geodetic coordinates and elevation of an item or a location, utilizing a stereo image database. PSS generates the precise true geodetic coordinates and elevation of any identifiable point or target contained within the area provided by the image database.
    Type: Grant
    Filed: March 25, 2004
    Date of Patent: October 21, 2008
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Michael Mathew Wirtz, Michael Robert Havlin, Diane Sue Tilley, Frank Joseph Modlinski, Michael David Thomas, Louis Christopher Miller, William Rodney Ditzler, James Edward McKnight
  • Patent number: 6988049
    Abstract: An embodiment of the present invention utilizes the Reference Point Method (RPM). RPM generates a local magnetic declination variance that is exact for the location of the OP, utilizing an optical stereo imagery database. RPM functions to determine true geodetic coordinates of a target position not available to be displayed in an image database, such as, for example, movable equipment.
    Type: Grant
    Filed: March 25, 2004
    Date of Patent: January 17, 2006
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Michael Mathew Wirtz, Michael Robert Havlin, Diane Sue Tilley, Frank Joseph Modlinski, Michael David Thomas, Louis Christopher Miller, William Rodney Ditzler, James Edward McKnight
  • Patent number: 6303382
    Abstract: The invention relates to a method for producing an integrant(s) of Bacillus thuringiensis which produces a larger quantity of a crystal delta-endotoxin with greater pesticidal activity as compared to the crystal delta-endotoxin produced by the corresponding parental strain. The crystal delta-endotoxin produced by the integrant Bacillus thuringiensis will have an activity directed towards the same pest(s) as its parent Bacillus thuringiensis crystal delta-endotoxin. The invention further relates to such integrants, compositions comprising such integrants, as well as methods for controlling a pest(s) using these compositions.
    Type: Grant
    Filed: December 20, 1996
    Date of Patent: October 16, 2001
    Inventors: Lee Fremont Adams, Michael David Thomas, Alan P. Sloma, William R. Widner
  • Patent number: 6280721
    Abstract: The invention relates to a method for producing an integrant(s) of Bacillus thuringiensis. The invention further relates to such integrants, compositions comprising such integrants, as well as methods for controlling a pest(s) using these compositions.
    Type: Grant
    Filed: January 25, 1995
    Date of Patent: August 28, 2001
    Assignee: Valent BioSciences, Inc.
    Inventors: Lee Fremont Adams, Michael David Thomas, Alan P. Sloma, William R. Widner, Steen Troels Jørgensen, Per Linå Jørgensen, Børge Krag Diderichsen
  • Patent number: 6280720
    Abstract: The invention relates to a method for producing an integrant(s) of Bacillus thuringiensis which produces a larger quantity of a crystal delta-endotoxin greater pesticidal activity as compared to the crystal delta-endotoxin produced by the corresponding parental strain. The crystal delta-endotoxin produced by the integrant Bacillus thuringiensis will have an activity directed towards the same pest(s) as its parent Bacillus thuringiensis crystal delta-endotoxin. The invention further relates to such integrants, compositions comprising such integrants, as well as methods for controlling a pest(s) using these compositions.
    Type: Grant
    Filed: July 13, 1994
    Date of Patent: August 28, 2001
    Assignees: Valant BioSciences, Inc., Libertyville, Inc.
    Inventors: Lee Fremont Adams, Michael David Thomas, Alan P. Sloma, William R. Widner
  • Patent number: 6270760
    Abstract: The invention relates to a method for producing an integrant(s) of Bacillus thuringiensis. The invention further relates to such integrants, compositions comprising such integrants, as well as methods for controlling a pest(s) using these compositions.
    Type: Grant
    Filed: June 10, 1997
    Date of Patent: August 7, 2001
    Assignee: Valent BioSciences, Inc.
    Inventors: Lee Fremont Adams, Michael David Thomas, Alan P. Sloma, William R. Widner, Steen Troels Jørgensen, Per Linå Jørgensen, Børge Krag Diderichsen
  • Patent number: 6156308
    Abstract: The invention is related to a novel biologically pure Bacillus thuringiensis (B.t.) strains active against lepidopteran and coleopteran pests which produces a bipyramidal crystal consisting essentially of at least two delta-endotoxins having a molecular weight of about 130,000 daltons and a rhomboidal crystal consisting essentially of two delta-endotoxins, each having a molecular weight of about 33,000 daltons, as well as spores, crystals, delta-endotoxins and/or mutants thereof. The invention also relates to insecticidal compositions obtainable therefrom. The invention further relates to methods of using the insecticidal compositions to control an insect pest(s) from the order Lepidoptera and/or Coleoptera. The invention also relates to isolated DNA sequences encoding the delta-endotoxins.
    Type: Grant
    Filed: March 2, 1998
    Date of Patent: December 5, 2000
    Assignee: Valent BioSciences, Inc.
    Inventors: Chi-Li Liu, Lee Fremont Adams, Patricia A. Lufburrow, Michael David Thomas
  • Patent number: 5955367
    Abstract: The invention relates to a method for producing an integrant(s) of Bacillus thuringiensis. The invention further relates to such integrants, compositions comprising such integrants, as well as methods for controlling a pest(s) using these compositions.
    Type: Grant
    Filed: April 14, 1998
    Date of Patent: September 21, 1999
    Assignee: Abbott Laboratories
    Inventors: Lee Fremont Adams, Michael David Thomas, Alan P. Sloma, William R. Widner, Steen Troels J.o slashed.rgensen, Per Lin.ang. J.o slashed.rgensen, B.o slashed.rge Krag Diderichsen
  • Patent number: 5879676
    Abstract: The invention is related to a novel biologically pure Bacillus thuringiensis (B.t.) strains active against lepidopteran and coleopteran pests which produces a bipyramidal crystal consisting essentially of at least two delta-endotoxins having a molecular weight of about 130,000 daltons and a rhomboidal crystal consisting essentially of two delta-endotoxins, each having a molecular weight of about 33,000 daltons, as well as spores, crystals, delta-endotoxins and/or mutants thereof. The invention also relates to insecticidal compositions obtainable therefrom. The invention further relates to methods of using the insecticidal compositions to control an insect pest(s) from the order Lepidoptera and/or Coleoptera. The invention also relates to isolated DNA sequences encoding the delta-endotoxins.
    Type: Grant
    Filed: November 10, 1994
    Date of Patent: March 9, 1999
    Assignee: Abbott Laboratories
    Inventors: Chi-Li Liu, Lee Fremont Adams, Patricia A. Lufburrow, Michael David Thomas
  • Patent number: 5770431
    Abstract: The invention is related to a novel biologically pure Bacillus thuringiensis (B.t.) strains active against lepidopteran and coleopteran pests which produces a bipyramidal crystal consisting essentially of at least two delta-endotoxins having a molecular weight of about 130,000 daltons and a rhomboidal crystal consisting essentially of two delta-endotoxins, each having a molecular weight of about 33,000 daltons, as well as spores, crystals, delta-endotoxins and/or mutants thereof. The invention also relates to insecticidal compositions obtainable therefrom. The invention further relates to methods of using the insecticidal compositions to control an insect pest(s) from the order Lepidoptera and/or Coleoptera. The invention also relates to isolated DNA sequences encoding the delta-endotoxins.
    Type: Grant
    Filed: May 3, 1995
    Date of Patent: June 23, 1998
    Assignee: Abbott Laboratories
    Inventors: Chi-Li Liu, Lee Fremont Adams, Patricia A. Lufburrow, Michael David Thomas