Abstract: Provided herein are inhibitors of AKT1, pharmaceutical compositions comprising the inhibitory compounds, and methods for using the AKT1 inhibitory compounds for the treatment of disease.

Abstract: A solid state light sheet and method of fabricating the sheet are disclosed. In one embodiment, bare LED chips have top and bottom electrodes, where the bottom electrode is a large reflective electrode. The bottom electrodes of an array of LEDs (e.g., 500 LEDs) are bonded to an array of electrodes formed on a flexible bottom substrate. Conductive traces are formed on the bottom substrate connected to the electrodes. A transparent top substrate is then formed over the bottom substrate. Various ways to connect the LEDs in series are described along with many embodiments. In one method, the top substrate contains a conductor pattern that connects to LED electrodes and conductors on the bottom substrate.

Abstract: Systems and methods are disclosed herein for adjusting flash intensity based on retinal pigmentation. In an embodiment, a processor determines a retinal pigmentation of a retina of an eye positioned at an imaging device. The processor commands the imaging device to adjust an intensity of a flash component from a first intensity to a second intensity based on the retinal pigmentation. The processor commands the imaging device to capture an image that is lit by the flash component at the second intensity, and receives the image from the imaging device.

Abstract: A blower includes a housing including an inlet and an outlet, a bearing-housing structure provided to the housing and adapted to rotatably support a rotor, a motor provided to the bearing-housing structure and adapted to drive the rotor, and an impeller provided to the rotor. The bearing-housing structure includes a bearing shaft having a bearing surface that rotatably supports the rotor. The bearing shaft provides only a single bearing of the non-ball bearing type for the rotor.

Abstract: A method for developing a containerized application using a pipeline platform consisting of a plurality of stages with associated development tools, the method comprising the steps of: receiving application parameters and a check-in code for the containerized application; generating a configuration file based on the application parameters, the configuration file containing configuration content including insert code; embedding the insert code into the check-in code; dynamically provisioning an opinionated pipeline based on contents of the configuration file, the opinionated pipeline including the plurality of stages with the associated development tools; setting up one or more control gates in one or more of the plurality of stages; receiving customized code for the containerized application, the customized code representing modifications of the insert code; and packaging the containerized application to include code contents of the check-in code, the customized code, and the insert code; wherein the containe

Abstract: A plating solution for electroless plating is disclosed, the solution including a metal salt, a reducing agent, a complexing agent, and a dispersion including polytetrafluoroethylene (PTFE) particulate matter and at least one particulate matter stabilizer, where said dispersion includes 400 parts per million or less of perfluorooctanoic acid (PFOA), and said dispersion is usable for an electroless plating bath to form a coating including PTFE particulate matter on an article.

Abstract: An enclosure system for a building includes an entryway for the building defined by opposing left and right frame-side jambs and a frame-side transom extending between the left and right frame-side jambs, and a temporary enclosure system removably installable within the entryway. After removing the temporary enclosure system from the entryway, the enclosure system further includes a left door-side jamb attachable to the left frame-side jamb to form an assembled left jamb, a right door-side jamb attachable to the right frame-side jamb to form an assembled right jamb, and a door-side transom attachable to the frame-side transom to form an assembled transom. One or more doors are hung within the entryway and extend laterally between the assembled left and right jambs and vertically to the assembled transom.

Abstract: Aspects of the disclosure relate to a method, apparatus, and system for restraining a passenger in a ride vehicle. The system includes a ride seat and a restraint system configured to restrain the passenger against the ride seat. The restraint system includes a crossbar for placing against the passenger, a support bar having a first support bar end coupled to the crossbar and a second support bar end rotatably coupled to a pivot mounted to an upper-rear portion of the ride seat, and a flap coupled to the support bar. The flap is configured to insert into, or extract from, a slot formed within a seat side structure when the support bar is rotated about the pivot and indicate whether the crossbar has attained a minimum closed position for restraining the passenger based on a position of a marking on the flap relative to the slot.

Abstract: An impact driver separation device for spacecraft and other vehicular separation mechanisms including a first element, second element, first connector, second connector, and impact actuator. The first element and the second element are joined by the first connector and the second connector. The impact actuator connects to the first connector or the second connector. In one example, the first connector is a bolt, and the second connector is a nut. In another example, the first connector is a nut, and the second connector is a bolt. When the impact actuator connects to the first connector, the impact actuator permits removal of the first connector from the second connector for separation of the first element and the second element. When the impact actuator connects to the second connector, the impact actuator permits removal of the second connector from the first connector for separation of the first element and the second element.

Abstract: Systems, devices, media, and methods are presented for assigning configuration parameters to unknown devices by comparing characteristics of unknown devices to characteristics of known devices. Characteristics of an unknown device are compared to characteristics of known devices to identify a similar device having known configuration parameters. The unknown devise is then assigned the configuration parameters of the identified similar device.

Abstract: Various examples described herein are directed to systems and methods that retrieve data from an information source. The data includes a first data set for a party and a second data set. The second data set has an entity associated with the party and a role of the party at the entity. The first data set is stored at a database and the second data set is stored at a cross-reference table associated with the database. A data request for requested information is received and the first data set is retrieved from the database. The second data set is retrieved from the cross-reference table based on the first data set. A hierarchical structure is created based on the second data set, where the hierarchical structure has different lists based on one of the entity and the role of the party at the entity.

Abstract: Clustering a plurality of client devices running an application as a function of a data structure such that the plurality of client devices are each assigned a cluster. Client devices having similar performance metrics are assigned the same cluster. An operation of the application is modified as a function of the performance metrics of the client device. The modification of application operation is performed by turning certain features of the application on and off using a rule based on device cluster.

Abstract: The present disclosure relates, in general, to improved processes for the preparation of 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)-benzamide, particularly large-scale processes for manufacturing 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide and intermediates used in such processes.

Abstract: An apparatus for promoting vascular circulation, including a garment configured to at least partially surround an anatomical structure of a patient. A compression element is coupled to the garment and configured to compress at least a portion of the anatomical structure when the compression element is actuated. A controller is configured to selectively actuate the compression element over a plurality of cycles. Each cycle has an actuated time during which the compression element is arranged to exert a first pressure and an unactuated time during which the compression element is arranged to exert a second pressure different than the first pressure, and the controller is configured to use a random value in determining the deflated time of one or more of the cycles.

Abstract: Pennycress seed, seed lots, and seed meal having reduced fiber content and improved suitability for use in producing animal feed are provided.

Abstract: An anti-rollout assembly may comprise: a housing defining a cavity; a guide/restraint head pivotably coupled to the housing at a first end of the cavity; an overridable trigger pivotably coupled to the housing at a second end of the cavity, the second end opposite the first end; and a locking system operably coupled to the guide/restraint head and the overridable trigger, the locking system configured to bias the guide/restraint head into an upright position, the locking system configured to retract the guide/restraint head into the cavity in response to a first lateral force driving the overridable trigger. The locking system may comprise a drive link and a locking link and be configured to lock the guide/restraint head in a raised state.

Abstract: There is provided a semiconductor device 1 which comprises: a housing comprising a first housing electrode 5 and a second housing electrode 4 which are arranged at opposite sides of the housing; a plurality of semiconductor units 30 arranged within the housing between the first and second housing electrodes 4, 5; a plurality of pressure means 40 for applying pressure to the plurality of semiconductor units 30, respectively, wherein the plurality of pressure means 40 are arranged between the plurality of semiconductor units 30 and the first housing electrode 5; a first conductive structure 14 arranged between the plurality of pressure means 40 and the plurality of semiconductor units 30, wherein the plurality of semiconductor units 30 are electrically connected in parallel between the second housing electrode 4 and the first conductive structure 14; and a second conductive structure 18 configured to provide a current flow path from the first conductive structure 14 to the first housing electrode 5, the second

Abstract: Freshening composition having at least 85% by weight of the freshening composition of water; at least 0.0015% of by weight of the freshening composition of alkoxylated phenol; and a perfume having at least 60% by weight of the perfume, Perfume Raw Materials having ClogP greater than 1.0. The alkoxylated phenol is according to Formula (I): wherein a is a value selected from 3 to 15; b is a value selected from 0 to 12; wherein the value of a+b, the degree of alkoxylation is from 3 to 15.

Abstract: A transaction is detected on a transaction terminal. A first code is presented on a display of the transaction terminal that is encoded with an identifier and a passcode for a wireless connection between the transaction terminal and a mobile device operated by a customer. The mobile device processes the code to wirelessly connect to the transaction terminal using the identifier and the passcode. A second code is presented on a display of the transaction terminal. The second code when captured by the mobile device causes a transaction interface to be remoted from the transaction terminal to the mobile device over the wireless connection. The transaction continues with interactions provided on the mobile device and processed on the transaction terminal without any customer touching of the display of the transaction terminal and without any customer touching of any keys or keypad of the transaction terminal.

Abstract: A transaction is detected on a transaction terminal. A first code is presented on a display of the transaction terminal that is encoded with an identifier and a passcode for a wireless connection between the transaction terminal and a mobile device operated by a customer. The mobile device processes the code to wirelessly connect to the transaction terminal using the identifier and the passcode. A second code is presented on a display of the transaction terminal. The second code when captured by the mobile device causes a transaction interface to be remoted from the transaction terminal to the mobile device over the wireless connection. The transaction continues with interactions provided on the mobile device and processed on the transaction terminal without any customer touching of the display of the transaction terminal and without any customer touching of any keys or keypad of the transaction terminal.