Abstract: Provided herein is a method for treating cancer in a patient in need thereof, wherein said cancer has a tumor proportion score (TPS) for programmed death receptor-1 (PD-1) or programmed death-ligand-1 (PD-L1) of 50% or less and said patient is negative for lymphatic dysfunction, comprising administering a therapeutically effective amount of an antagonist for immune checkpoint inhibition.

Abstract: An apparatus and method are provided for configuring a communication link. The apparatus has a plurality of antenna elements to support RF communication over a communication link using a plurality of frequency channels, a plurality of RF processing circuits, and configuration circuitry to apply a selected configuration from a plurality of different configurations, where each configuration identifies which RF processing circuit each antenna element is coupled to, and which frequency channel is allocated to each RF processing circuit. The configuration circuitry is arranged to employ a reinforcement learning process in order to dynamically alter which of the plurality of different configurations to apply as a currently selected configuration.

Abstract: Disclosed herein are heteroduplex nucleic acid molecules, heteroduplex nucleic acid conjugates, and pharmaceutical compositions for modulating a protein expression. Also described herein include methods of treating a disease or indication which utilize a heteroduplex nucleic acid molecule, a heteroduplex nucleic acid conjugate, or a pharmaceutical composition that comprises a heteroduplex nucleic acid molecule.

Abstract: Pennycress (Thlaspi arvense) seed, seed lots, seed meal, and compositions with reduced glucosinolate content as well as plants that yield such seed, seed lots, seed meal, and compositions are provided. Methods of making and using the pennycress plants and/or seed that provide such seed, seed lots, seed meal, and compositions are also provided.

Abstract: A method for preventing the development of or treating GvHD complications in a mammalian patient which comprises administering to the mammal a population of cells enriched for STRO-1bright cells and/or progeny thereof and/or soluble factors derived therefrom.

Abstract: Embodiments of synthetic garnet materials having advantageous properties, especially for below resonance frequency applications, are disclosed herein. In particular, embodiments of the synthetic garnet materials can have high Curie temperatures and dielectric constants while maintaining low magnetization. These materials can be incorporated into isolators and circulators, such as for use in telecommunication base stations.

Abstract: Techniques for managing support computing services in computing systems are disclosed. One example technique includes analyzing data representing a service ticket having data representing multiple messages exchanged between the user and a support entity of a support tier in the computing system. Based on the analysis, an interaction pattern in the multiple messages can be identified. The interaction pattern includes a sequence of words or phrases arranged in a chronological order. The method can further include determining whether the identified interaction pattern matches one or more interaction patterns corresponding to previously escalated service tickets and triggering a notification of the immediate escalation of the service ticket to another support entity in another support tier in response to determining that the interaction pattern matches one of the one or more interaction patterns corresponding to previously escalated service tickets.

Abstract: Disclosed herein are methods and systems for detection and discrimination of optical signals from a densely packed substrate. These have broad applications for biomolecule detection near or below the diffraction limit of optical systems, including in improving the efficiency and accuracy of polynucleotide sequencing applications.

Abstract: This disclosure relates to a banknote validator. The banknote validator comprises a banknote path formed within an interior of the banknote validator to transport a banknote from an opening of the banknote path through the interior of the banknote validator, one or more banknote edge detection surfaces each configured to provide images of edges of a banknote in the banknote path, an image sensor configured to capture the images of the edges of the banknote provided by the one or more banknote edge detection surfaces, a steerable drive wheel at least partially disposed within the banknote path, the steerable drive wheel operable to reorient a banknote in the banknote path, and the steerable drive wheel operable to move from a first position to a second position to angle the steerable drive wheel in relation to the banknote path.

Abstract: Embodiments of a community-integrated smart playground of this disclosure and a method of its use include tracking geo-specific play data, populating a queue of digital notices, displaying one or more of the digital notices on a mobile device as a user plays on the playground and progresses through a virtual game dependent upon the playground activity, and producing revenue for the playground through the display or use of the digital notices. The playground includes at least one physical play structure containing a computer-readable identification tag, the at least one physical play structure representing a physical play activity. The virtual game may be non-analogous to the physical play but game progress is determined by the physical play. The system and method of its use may be executed by at least one mobile device having at least one microprocessor in network communication with the computer-readable identification tag and including associated software.

Abstract: An attenuator for high pressure fluid systems includes a shielding stud including first and second ends and a cylindrical space extending therebetween. The attenuator comprises a cylindrical, attenuator body disposed within the cylindrical space and defining a pressure chamber therein. First and second seal heads are positioned within first and second ends of said shielding stud and coupled to the attenuator body using a tensioner assembly and a plug threadingly coupled to first and second inner threaded surfaces of the shielding stud in first and second ends thereof.

Abstract: Point to point transmission holograms are used to provide a scene camera for an augmented reality glasses display system. A glass or plastic substrate acts as spectacle style lens. A holographic medium is applied to a surface of the substrate, within which is recorded a series of point to point transmission holograms. The construction points of the holograms are arranged at the eye and at the pupil of a camera placed, ideally, to the temple side of the user's eye. The recorded transmission holograms act by diffracting a portion of the light from the scene surrounding the user that is heading for the user's eye towards the scene camera. The hologram efficiency is balanced so that the user is still able to see the surrounding scene. The perspective of the view seen by the scene camera is substantially identical to that seen by the user through the lens.

Abstract: According to the present invention there is provided an aqueous concentrated cosmetic composition comprising at least 20% water, at least 4.5% by weight of the composition of humectant, at least 8% of the composition of a peptide and high levels of a skin benefit active(s).

Abstract: Methods and systems for creating a multi-applicant account profile are described. During a first remote session, a first applicant provides at least two pieces of contact data for second applicant. A unique link and a one-time password are transmitted to the second applicant using respective first and second pieces of contact data. A second remote session is initiated, in response to receipt of the one-time password, provided via the unique link. During the second remote session, identification information of the second applicant is provided. A new multi-applicant account profile is then created, after verifying the identification information of the first applicant and the second applicant.

Abstract: Systems, apparatus and methods are provided for measuring moving vehicle information. Moving vehicle information may be measured by a sensor configured to respond to one or more wheels of the moving vehicle, where one or more of the wheels change the characteristic impedance of the sensor at the wheel's contact location. An electrical time domain reflectometry signal processing system which is capable of measuring the change in the impedance of the sensor and converting the impedance change to a signal may be connected operatively to the sensor. A data-processing system receives the signal and extracts the moving vehicle information therefrom.

Abstract: Systems, programs, non-transitory computer readable mediums, and methods of managing multiple and concurrent online advertising campaigns to eliminate user fatigue are disclosed. In particular, a campaign management server generates multiple target lists of users from a data warehouse for a plurality of pre-defined online advertising campaigns. The users on the target lists are selected to receive electronic communications, such as email or text, containing advertisements based upon target profiles associated with the campaigns as determined by marketing objectives. The advertising campaigns are prioritized such that users on a target list of a higher prioritized campaign are suppressed from lower prioritized campaigns in order to insure that the users receive a predetermined number of electronic communications within a set time frame.

Abstract: A method enables the transmission of encrypted and unencrypted data over different channels. The method includes: receiving, at a first device, unencrypted data via a first channel; causing, by the first device, generating a data entry form at a second device based on the received unencrypted data; causing, by the first device, transmitting, from the second device, the generated data entry form to a third device via a second channel, the generated data entry to be displayed within a webpage on the third device; causing, by the first device, intercepting and encrypting data entered into the generated data entry from by a user; and receiving, by the first device, via the second channel the encrypted data.

Abstract: Systems, methods, apparatus and computer-readable medium are described for improving efficiency and robustness for configuring data-planes. Furthermore, systems, methods, and devices are provided for efficiently storing, maintaining and retrieving configuration information for data-planes. The configuration information may be stored and retrieved from a hierarchy of information stored in memory, such as a hierarchy of information in memory, wherein the hierarchy of information has configuration data for one or more data-planes and represents one or more command sequences issued by a controller of the control-plane to one or more data-planes. In certain implementations, the hierarchy of information comprises a plurality of nodes, wherein each node represents at least a portion of a command sequence issued by the controller. The command sequences may be configuration command sequences issued by the control plane to configure the data-planes.

Abstract: Methods and systems are provided for small molecule analyte detection using digital signals, key encryption, and communications protocols. The methods provide detection of a large numbers of proteins, peptides, RNA molecules, and DNA molecules in a single optical or electrical detection assay within a large dynamic range.

Abstract: A multimode clutch assembly is positioned in a powertrain of a rotorcraft. The clutch assembly includes a freewheeling unit having a driving mode in which torque applied to the input race is transferred to the output race and an overrunning mode in which torque applied to the output race is not transferred to the input race. A bypass assembly has an engaged position that couples the input and output races of the freewheeling unit. An actuator assembly shifts the bypass assembly between engaged and disengaged positions. An engagement status sensor is configured to determine the engagement status of the bypass assembly. In the disengaged position, the overrunning mode of the freewheeling unit is enabled such that the clutch assembly is configured for unidirectional torque transfer. In the engaged position, the overrunning mode of the freewheeling unit is disabled such that the clutch assembly is configured for bidirectional torque transfer.