Abstract: The invention provides a polymyxin compound of formula (1) and salts, solvates and protected forms thereof, pharmaceutical compositions comprising the compounds of formula (1), and the use of the compounds and compositions in methods of treatment, such as methods for the treatment of microbial infections. The compounds of formula (1) are represented thus: wherein —R15 is a group: and —R16 is hydrogen; —R17 is hydrogen -L- is a covalent bond or methylene; and —Ar is optionally substituted aryl. The groups —X—, —R1, —R2, —R3, —R4, and —R8 are as defined herein.

Abstract: The invention provides a polymyxin compound of formula (I) and salts, solvates and protected forms thereof, pharmaceutical compositions comprising the compounds of formula (I), and the use of the compounds and compositions in methods of treatment, such as methods for the treatment of microbial infections. The compounds of formula (I) are represented thus: wherein —R15 is a group: and —R16 is hydrogen; —R17 is hydrogen; -L- is a covalent bond or methylene; and —Ar is optionally substituted aryl. The groups —X—, —R1, —R2, —R3, —R4, and —R8 are as defined herein.

Abstract: A surface cleaner configured to distribute a liquid to a surface to be cleaned. The surface cleaner includes a supply tank and a recovery tank that are removable from the surface cleaner.

Abstract: An apparatus for use in turning steerable vehicle wheels includes a steering member which is axially movable relative to the vehicle to effect turning movement of the steerable vehicle wheels. A ball nut assembly is connected with an externally threaded portion of the steering member. A first motor connected with the ball nut assembly by a belt is operable to effect rotation of the ball nut assembly relative to the steering member. A second motor connected with the ball nut assembly and the first motor by the belt is operable to effect rotation of the ball nut assembly relative to the steering member.

Abstract: A floor cleaner including a including a body, a cleaning head pivotally coupled to the body, and a liquid distribution system. The cleaning head includes a first and a second cleaning roller for contacting a surface to be cleaned.

Abstract: The present invention provides a compound of formula (I), and its use in methods of treatment, including the treatment of bacterial infections. Methods for the preparation of the compound of formula (I) are also provided.

Abstract: A steer-by wire apparatus for use in turning steerable vehicle wheels includes a steering member which is axially movable relative to the vehicle to effect turning movement of the steerable vehicle wheels. A ball nut assembly is connected with an externally threaded portion of the steering member. The steering member moves axially in response to rotation of the ball nut assembly relative to the steering member. A first motor connected with the ball nut assembly is operable to effect rotation of the ball nut assembly relative to the steering member. A pinion is in meshing engagement with the steering member. The steering member moves axially in response to rotation of the pinion. A second motor connected with the pinion is operable to effect rotation of the pinion relative to the steering member.

Abstract: An apparatus for use in turning steerable vehicle wheels includes a steering member which is axially movable relative to the vehicle to effect turning movement of the steerable vehicle wheels. A ball nut assembly is connected with an externally threaded portion of the steering member. A first motor connected with the ball nut assembly by a belt is operable to effect rotation of the ball nut assembly relative to the steering member. A second motor connected with the ball nut assembly and the first motor by the belt is operable to effect rotation of the ball nut assembly relative to the steering member.

Abstract: A floor cleaner including a including a body, a cleaning head pivotally coupled to the body, and a liquid distribution system. The cleaning head includes a first and a second cleaning roller for contacting a surface to be cleaned.

Abstract: A surface cleaner configured to distribute a liquid to a surface to be cleaned. The surface cleaner includes a supply tank, a fluid distributor, a suction inlet aperture, a recovery tank and a tool removably connectable to the surface cleaner and configured to direct fluid from the fluid distributor into the suction inlet aperture to rinse the suction inlet aperture.

Abstract: A surface cleaner configured to distribute a liquid to a surface to be cleaned. The surface cleaner includes a supply tank and a recovery tank that are removable from the surface cleaner.

Abstract: An apparatus for use in turning steerable vehicle wheels includes a steering member which is axially movable relative to the vehicle to effect turning movement of the steerable vehicle wheels. A ball nut assembly is connected with an externally threaded portion of the steering member. A first motor is connected with the ball nut assembly. The first motor is operable to effect rotation of the ball nut assembly relative to the steering member. A second motor is connected with the ball nut assembly. The second motor is operable to effect rotation of the ball nut assembly relative to the steering member.

Abstract: A surface cleaner configured to distribute a liquid to a surface to be cleaned. The surface cleaner includes a supply tank, a fluid distributor, a suction inlet aperture, a recovery tank and a tool removably connectable to the surface cleaner and configured to direct fluid from the fluid distributor into the suction inlet aperture to rinse the suction inlet aperture.

Abstract: The present invention provides a compound of formula (I), and its use in methods of treatment, including the treatment of bacterial infections. Methods for the preparation of the compound of formula (I) are also provided.

Abstract: Provided are compounds of formula (III), and the use of compounds of formula (III) in methods of treatment, such as methods of treating a microbial infection. The compounds of formula (III) is: where —R15 is an amino-containing group: and —R1, —R2, —R3, —R4, —R8, —RA, Q, —R16, —R17 are as described in further detail in the description.

Abstract: A floor cleaner including a including a body, a cleaning head pivotally coupled to the body, and a liquid distribution system. The cleaning head includes a first and a second cleaning roller for contacting a surface to be cleaned.

Abstract: A smart contract clause can be generated with a processor communicatively coupled to a blockchain supported by a peer-to-peer network. The smart contract clause can be automatically invoked in response to a sensor-generated signal, wherein the sensor-generated signal corresponds to at least one or more predefined contract variance conditions. The smart contract clause can be embedded in a smart contract in the blockchain.

Abstract: A stator is described herein comprising a first longitudinally extending slot having a cavity defined by a first inwardly facing longitudinal surface and a second inwardly facing longitudinal surface; said stator further comprising a spacer provided in said cavity of said first slot, said spacer comprising a first spacer component that comprises a first sheet of material having a first sheet surface facing inwardly into said slot and an opposite sheet surface that is in contact with and extends along the first longitudinally extending inner surface of said slot and wherein said inwardly facing first sheet surface of said first spacer component comprises at least one ridge projection extending along its length L. Methods for assembling such stators are also described.

Abstract: The invention provides a polymyxin compound of formula (I) and salts, solvates and protected forms thereof, pharmaceutical compositions comprising the compounds of formula (I), and the use of the compounds and compositions in methods of treatment, such as methods for the treatment of microbial infections. The compounds of formula (I) are represented thus: wherein —R15 is a group: and —R16 is hydrogen; —R17 is hydrogen; -L- is a covalent bond or methylene; and —Ar is optionally substituted aryl. The groups —X—, —R1, —R2, —R3, —R4, and —R8 are as defined herein.