Abstract: Systems, methods, and computer program products are provided herein for dynamic access permissions to secure data resources in a distributed network. An example method includes identifying an application from amongst a plurality of applications with which the system interacts and determining one or more access permissions associated with secure interactions between the system and the identified application. The method further includes determining an absence of a least a first access permission from amongst the one or more access permissions with respect to the system and modifying a database of the system to register the at least first access permission. The one or more access permissions associated with the secure interactions between the system and the identified application define an interaction time period during which at least a first portion of the one or more access permissions were used.

Abstract: Provided herein are multi-chain chimeric polypeptides and use thereof in the treatment of liver diseases.

Abstract: An assembly for a watercraft according to an example of the present disclosure includes, among other things, a flotation device including an elongated slot and a mount that has first and second flanges extending outwardly from a bracket body. The first flange is configured to be mechanically attached to a frame, and the second flange is slideably received in the slot to secure the flotation device. A method of assembly for a watercraft is also disclosed.

Abstract: Provided herein are methods of stimulating or increasing the proliferation of a Treg cell, compositions including a population of Treg cells generated by these methods, and methods of treating a subject using these compositions.

Abstract: An assembly for a watercraft according to an example of the present disclosure includes, among other things, a flotation device including an elongated slot and a mount that has first and second flanges extending outwardly from a bracket body. The first flange is configured to be mechanically attached to a frame, and the second flange is slideably received in the slot to secure the flotation device. A method of assembly for a watercraft is also disclosed.

Abstract: An assembly for a watercraft according to an example of the present disclosure includes, among other things, a flotation device defining an elongated slot extending between opposed ends of the flotation device, and an elongated mount that has first and second flanges extending outwardly from a bracket body. The first flange is configured to be mechanically attached to a frame, and the second flange is slideably received in the elongated slot to secure the flotation device. A method of assembly for a watercraft is also disclosed.

Abstract: An assembly for a watercraft according to an example of the present disclosure includes, among other things, a flotation device defining an elongated slot extending between opposed ends of the flotation device, and an elongated mount that has first and second flanges extending outwardly from a bracket body. The first flange is configured to be mechanically attached to a frame, and the second flange is slideably received in the elongated slot to secure the flotation device. A method of assembly for a watercraft is also disclosed.

Abstract: A system comprising for communication medical data includes a patient data component, a provider component, a session component, an authorization component, and a communication component. The patient data component is configured to store patient medical data corresponding to one or more patients. The provider component is configured to store destination information corresponding to a plurality of health care providers that can receive the patient medical data from the system. The session component is configured to establish and validate communication with a first patient via a remote device. The authorization component is configured to receive, from the remote device, a message indicating authorization from the first patient to send the medical data for the first patient to a first health care provider. The communication component is configured to send the medical data for the first patient to the destination information corresponding to the first health care provider.

Abstract: A mobile computing device includes an authentication component, a destination component, a permission component, and a message component. The authentication component is configured to authenticate a user with an authentication server by providing authentication information to the authentication server. The destination component is configured to identify a health care provider available to provide health care for the user and to receive medical data. The permission component is configured to, in response to authenticating the user, receive input from a user indicating authorization to send medical data for the first patient to the health care provider. The message component is configured to send a message providing permission to a remote server to send medical data for the user stored in remote storage to the health care provider.

Abstract: Systems and methods for providing a multi-tier enterprise level application. In particular, the present invention relates to systems and methods for providing an architecture and interface for delivering customizable music and advertisements to remote retail locations. A client player computer device is located at the retail location and a server system is located at a remote location. The server system selectively provides broadcast information when an active contract, an active advertisement, and an active schedule are available. The client player computer device establishes a contact with a server at a predetermined time or upon request by the server or another source. The client player computer device executes a broadcast or program schedule that includes music content and advertisements, wherein the advertisements have been purchased as blocks of time by entities and are scheduled to be broadcast at particular times.

Abstract: The present application provides improved heat seal dies and methods of use thereof. The heat seal die includes a first heat seal jaw having a first heat sealing surface and a second heat seal jaw having a second heat sealing surface. The second heat seal jaw may have a plurality of channels and a plurality of resilient compressible members with each resilient compressible member being disposed within one of the channels. The plurality of resilient compressible members may form at least a portion of a second heat sealing surface.

Abstract: There is provided a series of substituted acyl guanidines of Formula (I) or a stereoisomer; or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, R7, and R8 as defined herein, their pharmaceutical compositions and methods of use. These compounds inhibit the processing of amyloid precursor protein (APP) by ?-secretase and, more specifically, inhibit the production of A?-peptide. The present disclosure is directed to compounds useful in the treatment of neurological disorders related to ?-amyloid production, such as Alzheimer's disease and other conditions affected by anti-amyloid activity.

Abstract: A germicidal method and apparatus for destroying airborne pathogenic bacteria such as tuberculosis bacteria using ultraviolet light. Air is drawn through a filter and into a sterilization chamber that is irradiated with ultraviolet light, and out through an exhaust opening. Consideration for the characteristics of the room in which the apparatus is installed and the positioning of the installation allows effective prevention of transmission of disease through expectoration and inhalation of airborne microdroplets of bacteria-containing sputum. The filter is of the low-density type which traps large particulates, but not small particulates of the size of the microdroplets, so that the filter does not become a bacteria colonization site. Baffles on the air intake opening and air exhaust opening to prevent ultraviolet light from escaping into the environment. The sterilization chamber is constructed such that the air passes the ultraviolet light bulbs twice as it circulates therethrough.

Abstract: Systems and methods for providing a multi-tier enterprise level application. In particular, the present invention relates to systems and methods for providing an architecture and interface for delivering customizable music and advertisements to remote retail locations. A client player computer device is located at the retail location and a server system is located at a remote location. The server system selectively provides broadcast information when an active contract, an active advertisement, and an active schedule are available. The client player computer device establishes a contact with a server at a predetermined time or upon request by the server or another source. The client player computer device executes a broadcast or program schedule that includes music content and advertisements, wherein the advertisements have been purchased as blocks of time by entities and are scheduled to be broadcast at particular times.

Abstract: A germicidal method and apparatus for destroying airborne pathogenic bacteria such as tuberculosis bacteria using ultraviolet light. Air is drawn through a filter and into a sterilization chamber that is irradiated with ultraviolet light, and out through an exhaust opening. Consideration for the characteristics of the room in which the apparatus is installed and the positioning of the installation allows effective prevention of transmission of disease through expectoration and inhalation of airborne microdroplets of bacteria-containing sputum. The filter is of the low-density type which traps large particulates, but not small particulates of the size of the microdroplets, so that the filter does not become a bacteria colonization site. Baffles on the air intake opening and air exhaust opening to prevent ultraviolet light from escaping into the environment.

Abstract: A germicidal method and apparatus for destroying airborne pathogenic bacteria such as tuberculosis bacteria using ultraviolet light. Air is drawn through a filter and into a sterilization chamber that is irradiated with ultraviolet light, and out through an exhaust opening. Consideration for the characteristics of the room in which the apparatus is installed and the positioning of the installation allows effective prevention of transmission of disease through expectoration and inhalation of airborne microdroplets of bacteria-containing sputum. The filter is of the low-density type which traps large particulates, but not small particulates of the size of the microdroplets, so that the filter does not become a bacteria colonization site. Baffles on the air intake opening and air exhaust opening to prevent ultraviolet light from escaping into the environment. The sterilization chamber is constructed such that the air passes the ultraviolet light bulbs twice as it circulates therethrough.

Abstract: A germicidal method and apparatus for destroying airborne pathogenic bacteria such as tuberculosis bacteria using ultraviolet light. Air is drawn through a filter and into a sterilization chamber that is irradiated with ultraviolet light, and out through an exhaust opening. Consideration for the characteristics of the room in which the apparatus is installed and the positioning of the installation allows effective prevention of transmission of disease through expectoration and inhalation of airborne microdroplets of bacteria-containing sputum. The filter is of the low-density type which traps large particulates, but not small particulates of the size of the microdroplets, so that the filter does not become a bacteria colonization site. Baffles on the air intake opening and air exhaust opening to prevent ultraviolet light from escaping into the environment. The sterilization chamber is constructed such that the air passes the ultraviolet light bulbs twice as it circulates therethrough.

Abstract: A germicidal method and apparatus for destroying airborne pathogenic bacteria such as tuberculosis bacteria using ultraviolet light. Air is drawn through a filter and into a sterilization chamber that is irradiated with ultraviolet light, and out through an exhaust opening. Consideration for the characteristics of the room in which the apparatus is installed and the positioning of the installation allows effective prevention of transmission of disease through expectoration and inhalation of airborne microdroplets of bacteria-containing sputum. The filter is of the low-density type which traps large particulates, but not small particulates of the size of the microdroplets, so that the filter does not become a bacteria colonization site. Baffles on the air intake opening and air exhaust opening to prevent ultraviolet light from escaping into the environment. The sterilization chamber is constructed such that the air passes the ultraviolet light bulbs twice as it circulates therethrough.

Abstract: The invention provides methods for identifying agents which modulate the interaction of a chemokine receptor of previously unknown function, Burkitt's Lymphoma Receptor 1 (BLR1), with its ligand, B Lymphocyte Chemoattractant (BLC). The methods find particular application in commercial drug screens.

Abstract: A transgenic, non-human animal is provided which overexpresses a gene responsible for the accumulation of monocytes and leukocytes. The animal is preferably a mammal and more preferably a mouse, rat or guinea pig. The transgenic animal is created by artificially inserting a transgene into a fertilized egg of the animal which egg is then inserted within a pseudo pregnant female where it is allowed to grow. The transgene preferably expresses human Monocyte Chemoattractant Protein-1 (MCP-1) and more preferably overexpresses MCP-1 in type II pulmonary epithelial cells. The invention includes DNA constructs and vectors containing the constructs with a particularly preferred vector being SPC-MCP-1. The plasmid SPC-MCP-1 includes a promoter operatively linked to a human MCP-1 coding sequence. The transgenic animal provides a useful animal model for testing drugs for their efficacy with respect to the treatment of diseases and conditions which result in an acceptable high accumulation of monocytes and/or lymphocytes.