Patents by Inventor Michael Denis Johnston

Michael Denis Johnston has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • RECOVERY OF VIRUS FROM CELL CULTURE USING HYPERTONIC SALT SOLUTION
    Publication number: 20090042273
    Abstract: A process of harvesting a herpesvirus from a cell culture infected therewith comprises treating said culture with a hypertonic aqueous salt solution to yield a virus suspension, e.g. to give improved yield of virus for live virus vaccine where otherwise cell-disruption might be used to harvest the virus by disrupting virus-infected cells. The harvesting step can be followed e.g. by nuclease treatment, diafiltration and lyophilisation.
    Type: Application
    Filed: September 11, 2008
    Publication date: February 12, 2009
    Inventors: Michael Denis Johnston, Roderic Simon O'Keeffe
  • Recovery of virus from cell culture using a hypertonic salt solution
    Publication number: 20030224502
    Abstract: A process of harvesting a herpesvirus from a cell culture infected therewith comprises treating said culture with a hypertonic aqueous salt solution to yield a virus suspension, e.g. to give improved yield of virus for live virus vaccine where otherwise cell-disruption might be used to harvest the virus by disrupting virus-infected cells. The harvesting step can be followed e.g. by nuclease treatment, diafiltration and lyophilisation.
    Type: Application
    Filed: May 30, 2003
    Publication date: December 4, 2003
    Applicant: Xenova Research Limited
    Inventors: Michael Denis Johnston, Roderic Simon O'Keeffe
  • Purification of biological preparations
    Patent number: 6310186
    Abstract: This invention relates to the purification of biological preparations such as proteins and nucleic acids, especially for example proteins that have been produced by recombinant DNA techniques in bacteria. In a particular embodiment, the invention concerns improved methods for reducing the content of contaminants in biological preparations, e.g. recombinant proteins produced in host bacteria.
    Type: Grant
    Filed: April 3, 2000
    Date of Patent: October 30, 2001
    Inventors: Mark Jonathon Wilson, Michael Denis Johnston, Deirdre Anne Glenn, Sean Patrick Gallagher
  • Virus preparations and methods
    Patent number: 6267967
    Abstract: Herpesvirus preparations, e.g. cultured HSV type 2, e.g. genetically disabled virus for vaccine use, can be purified, e.g. for subsequent pharmaceutical formulation, with solid phase affinity reagents containing sulfate- or sulfonate-comprising binding groups, e.g. sulfated polysacharide groups, e.g. heparin or dextran sulfate, and eluting e.g. with salt solutions. The process can be combined with other culture and harvesting steps.
    Type: Grant
    Filed: March 5, 1999
    Date of Patent: July 31, 2001
    Assignee: Cantab Pharmaceuticals Research Limited
    Inventors: Michael Denis Johnston, Roderic Simon O'Keeffe, Nigel Kenneth Harry Slater