Patents by Inventor Michael Doherty
Michael Doherty has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240375684Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for selecting a pull-over location using machine learning. One of the methods includes obtaining data specifying a target pull-over location for an autonomous vehicle travelling on a roadway. A plurality of candidate pull-over locations in a vicinity of the target pull-over location are identified. For each candidate pull-over location, an input that includes features of the candidate pull-over location is processed using a machine learning model to generate a respective likelihood score representing a predicted likelihood that the candidate pull-over location is an optimal location. The features of the candidate pull-over location include one or more features that compare the candidate pull-over location to the target pull-over location. Using the respective likelihood scores, one of the candidate pull-over locations is selected as an actual pull-over location for the autonomous vehicle.Type: ApplicationFiled: July 25, 2024Publication date: November 14, 2024Inventors: Jonathan Lee Pedersen, Yu Zheng, Eamonn Michael Doherty, Brian Clair Williammee, Kevin Joseph Malta, Chung Eun Kim, Xu Dong
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Publication number: 20240330581Abstract: A method includes: accessing a static visual objects, and media formats; defining a multi-dimensional feature space representing possible arrangements of combinations of the set of static visual objects within the set of media formats; generating a primary feature container distributed within the multi-dimensional feature space; generating a primary responsive media, by inserting the primary subset of static visual objects into the primary media format according to a primary arrangement of the primary subset of static visual objects represented in the feature container; presenting the primary responsive media to an operator; in response to receiving a selection of the primary responsive media generating a secondary feature container distributed within the multi-dimensional feature space proximal the primary feature container; generating a secondary responsive media, and serving the secondary responsive media to a first device for playback to a first user responsive to inputs by the first user at the first devType: ApplicationFiled: June 14, 2024Publication date: October 3, 2024Inventors: Connor Doherty, Farid Jawde, David Sebag, Michael Yavonditte
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Publication number: 20240308655Abstract: An aerial vehicle includes a fuselage supporting a pair of wings, with each of wings having a pair of booms attached thereto. A tilt rotor is positioned at each of the forward ends of each of the booms, to provide the aerial vehicle with at least four tilt rotors. A fixed rotor is positioned at and secured to the aft (or trailing) ends of each of the booms, to provide the aerial vehicle with at least four fixed rotors.Type: ApplicationFiled: May 10, 2024Publication date: September 19, 2024Inventors: Ian Andreas Villa, Jacek Kawecki, Jalen Christian Doherty, Ryan Naru, Mark Moore, Alex Michael Gary, Adam Chase, Matthew William Derkach, Philipp Haban
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Publication number: 20240294804Abstract: A method of bonding first and second substrates to each other the substrates having respective bonding surfaces to be bonded together, comprising: (a) applying to the bonding surface of at least the first substrate a redox-active metal catalyst primer to form a primed surface; (b) activating the primed bonding surface of the first substrate by exposing the primed bonding surface to actinic radiation; (c) applying, to the so activated bonding surface of the first substrate, and/or or to the bonding surface of the second substrate, a UV curable anaerobic adhesive; (d) mating the bonding surfaces together with the UV curable anaerobic adhesive therebetween; and (e) exposing the UV curable anaerobic adhesive between the mated surfaces to actinic UV radiation. The method is particularly suited for obtaining bonds with good tensile shear strength with electrical substrates coated with an insulating varnish.Type: ApplicationFiled: March 14, 2024Publication date: September 5, 2024Inventors: Michael Doherty, Brian Deegan, Stephen Fearon, David Condron, Barry Burns
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Publication number: 20240285550Abstract: The present invention relates to topical pharmaceutical emulsion compositions comprising a therapeutically effective amount of 3,5-Dihydroxy-4-isopropyl-trans-stilbene or a pharmaceutically acceptable salt thereof, an oil phase, a water phase, a surfactant, and an antioxidant, and wherein the emulsion composition is homogeneous and/or the active is solubilized in the oil phase. The invention also relates to methods of treating a dermatological condition or disorder in a patient by administering the present compositions to the skin of the patient.Type: ApplicationFiled: April 23, 2024Publication date: August 29, 2024Applicant: Dermavant Sciences GmbHInventors: Sujatha D. SONTI, Joey Roger THOMAS, Jon LENN, Leandro SANTOS, Justin WHITEMAN, Michael DOHERTY, Mary BEDARD, Piyush JAIN
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Publication number: 20240285611Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.Type: ApplicationFiled: August 15, 2023Publication date: August 29, 2024Applicant: ABBVIE INC.Inventors: Le WANG, George DOHERTY, Xilu WANG, Zhi-Fu TAO, Milan BRUNCKO, Aaron R. KUNZER, Michael D. WENDT, Xiaohong SONG, Robin FREY, Todd M. HANSEN, Gerard M. SULLIVAN, Andrew JUDD, Andrew SOUERS
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Patent number: 12071162Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for selecting a pull-over location using machine learning. One of the methods includes obtaining data specifying a target pull-over location for an autonomous vehicle travelling on a roadway. A plurality of candidate pull-over locations in a vicinity of the target pull-over location are identified. For each candidate pull-over location, an input that includes features of the candidate pull-over location is processed using a machine learning model to generate a respective likelihood score representing a predicted likelihood that the candidate pull-over location is an optimal location. The features of the candidate pull-over location include one or more features that compare the candidate pull-over location to the target pull-over location. Using the respective likelihood scores, one of the candidate pull-over locations is selected as an actual pull-over location for the autonomous vehicle.Type: GrantFiled: September 30, 2021Date of Patent: August 27, 2024Assignee: Waymo LLCInventors: Jonathan Lee Pedersen, Yu Zheng, Eamonn Michael Doherty, Brian Clair Williammee, Kevin Joseph Malta, Chung Eun Kim, Xu Dong
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Patent number: 12050863Abstract: A method includes: accessing a static visual objects, and media formats; defining a multi-dimensional feature space representing possible arrangements of combinations of the set of static visual objects within the set of media formats; generating a primary feature container distributed within the multi-dimensional feature space; generating a primary responsive media, by inserting the primary subset of static visual objects into the primary media format according to a primary arrangement of the primary subset of static visual objects represented in the feature container; presenting the primary responsive media to an operator; in response to receiving a selection of the primary responsive media generating a secondary feature container distributed within the multi-dimensional feature space proximal the primary feature container; generating a secondary responsive media, and serving the secondary responsive media to a first device for playback to a first user responsive to inputs by the first user at the first devType: GrantFiled: October 4, 2023Date of Patent: July 30, 2024Assignee: Yieldmo, Inc.Inventors: Connor Doherty, Farid Jawde, David Sebag, Michael Yavonditte
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Publication number: 20240241020Abstract: The present disclosure relates to methods for preparing extracellular vesicles (EVs). In particular, the methods provided herein comprise contacting a sample, which comprises EVs and one or more impurities, with a depth filter, wherein the depth filter is selected from a LA media grade depth filter, a SP media grade depth filter, or both. In some aspects, the methods further comprise one or more chromatography steps. The methods enable preparation of EVs for therapeutic and diagnostic applications, and isolation and/or sub-fractionation of EVs with desired properties for specific use.Type: ApplicationFiled: September 23, 2021Publication date: July 18, 2024Applicant: Lonza Sales AGInventors: Andrew WOOD, Michael DOHERTY, Aaron NOYES
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Publication number: 20240066433Abstract: The present disclosure relates to multistep chromatographic methods for preparing extracellular vesicles (EVs). The methods were demonstrated to be effective in preparing high-quality EVs in a large scale. The methods enable preparation of EVs for therapeutic and diagnostic applications, and isolation and/or sub-fractionation of EVs with desired properties for specific use.Type: ApplicationFiled: September 27, 2023Publication date: February 29, 2024Applicant: LONZA SALES AGInventors: Aaron NOYES, Michael DOHERTY, Kimberly ELLIS, Raymond BOURDEAU, Kayla DESANTY
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Publication number: 20240052219Abstract: An anaerobically curable composition comprising: a liquid anaerobically curable component; a solid anaerobically curable component; a solid polyether thermoplastic polyurethane resin; and a curing component for curing the anaerobically curable components. Advantageously, the compositions of the invention are substantially solid and may be used as threadlockers.Type: ApplicationFiled: October 19, 2023Publication date: February 15, 2024Inventors: Gavin Haberlin, Michael Doherty, Nigel Sweeney, Rory Barnes, David Condron, Barry Burns
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Publication number: 20230312800Abstract: The present invention relates to a curable composition comprising a curable cyanoacrylate component and at least one thermoplastic polyurethane (TPU) component. The compositions of the invention are non-flowable at room temperature (25° C.) and are suitable for use as adhesive compositions, for example in a tape form.Type: ApplicationFiled: June 8, 2023Publication date: October 5, 2023Inventors: Rory Barnes, Michael Doherty, Nigel Sweeney, Ciara Goff
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Publication number: 20230220254Abstract: A sealant material for sealing joints between male and female mating parts comprising: (a) an elongate flexible thread suitable for wrapping around at least one of the parts, and (b) a joint sealing composition comprising an anaerobically curable composition in solid form, the flexible thread being coated with the anaerobically curable composition. This provides a reactive composition on the thread for sealing joints.Type: ApplicationFiled: March 22, 2023Publication date: July 13, 2023Inventors: Deirdre Ledwith, Laura Vaissaud, Michael Doherty, James Houlihan, Brendan Kneafsey
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Publication number: 20230113686Abstract: An anaerobically curable composition comprising: a liquid anaerobically curable component; a solid anaerobically curable component; a solid thermoplastic polyurethane resin having a molecular weight in the range of from 40,000 g/mol to 100,000 g/mol and a melting point in the range of from 40° C. to 80° C.; and a curing component for curing the anaerobically curable components. Advantageously, the compositions of the invention are substantially solid and may be used as threadlockers.Type: ApplicationFiled: October 3, 2022Publication date: April 13, 2023Inventors: Nigel Sweeney, Brendan Kneafsey, Rory Barnes, Michael Doherty, James Anthony Houlihan
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Patent number: 11618841Abstract: A sealant material for sealing joints between male and female mating parts comprising: (a) an elongate flexible thread suitable for wrapping around at least one of the parts, and (b) a joint sealing composition comprising an anaerobically curable composition in solid form, the flexible thread being coated with the anaerobically curable composition. This provides a reactive composition on the thread for sealing joints.Type: GrantFiled: April 17, 2019Date of Patent: April 4, 2023Assignee: Henkel AG & Co. KGaAInventors: Deirdre Ledwith, Laura Vaissaud, Michael Doherty, James Houlihan, Brendan Kneafsey
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Publication number: 20230099334Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for selecting a pull-over location using machine learning. One of the methods includes obtaining data specifying a target pull-over location for an autonomous vehicle travelling on a roadway. A plurality of candidate pull-over locations in a vicinity of the target pull-over location are identified. For each candidate pull-over location, an input that includes features of the candidate pull-over location is processed using a machine learning model to generate a respective likelihood score representing a predicted likelihood that the candidate pull-over location is an optimal location. The features of the candidate pull-over location include one or more features that compare the candidate pull-over location to the target pull-over location. Using the respective likelihood scores, one of the candidate pull-over locations is selected as an actual pull-over location for the autonomous vehicle.Type: ApplicationFiled: September 30, 2021Publication date: March 30, 2023Inventors: Jonathan Lee Pedersen, Yu Zheng, Eamonn Michael Doherty, Brian Clair Williammee, Kevin Joseph Malta, Chung Eun Kim, Xu Dong
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Patent number: 11612573Abstract: The present invention relates to topical pharmaceutical emulsion compositions comprising a therapeutically effective amount of 3,5-Dihydroxy-4-isopropyl-trans-stilbene or a pharmaceutically acceptable salt thereof, an oil phase, a water phase, a surfactant, and an antioxidant, and wherein the emulsion composition is homogeneous and/or the active is solubilized in the oil phase. The invention also relates to methods of treating a dermatological condition or disorder in a patient by administering the present compositions to the skin of the patient.Type: GrantFiled: September 30, 2019Date of Patent: March 28, 2023Assignee: DERMAVANT SCIENCES GMBHInventors: Sujatha D. Sonti, Joey Roger Thomas, Jon Lenn, Leandro Santos, Justin Whiteman, Michael Doherty, Mary Bedard, Piyush Jain
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Publication number: 20220387906Abstract: The present disclosure relates to multistep chromatographic methods for preparing extracellular vesicles (EVs). The methods were demonstrated to be effective in preparing highquality EVs in a large scale. The methods enable preparation of EVs for therapeutic and diagnostic applications, and isolation and/or sub-fractionation of EVs with desired properties for specific use.Type: ApplicationFiled: March 20, 2020Publication date: December 8, 2022Applicant: Codiak BioSciences, Inc.Inventors: Aaron NOYES, Michael DOHERTY, Kimberly ELLIS, Raymond BOURDEAU, Kayla DESANTY
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Publication number: 20220390437Abstract: The present disclosure relates to high-throughput screening methods for identifying one or more chromatography operational parameters (e.g., binding parameters) and/or reagents for purifying EVs (e.g., exosomes) from a sample using chromatography. Also disclosed herein are methods for improving one or more aspects of EV (e.g., exosome) purification, e.g., improving EV yield, increasing EV ligand density, and/or reducing impurity recovery.Type: ApplicationFiled: November 5, 2020Publication date: December 8, 2022Applicant: Codiak BioSciences, Inc.Inventors: Michael DOHERTY, Aaron NOYES, Andrew WOOD
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Patent number: 11357824Abstract: Nutritive polypeptides are provided herein. Also provided are various other embodiments including nucleic acids encoding the polypeptides, recombinant microorganisms that make the polypeptides, vectors for expressing the polypeptides, methods of making the polypeptides using recombinant microorganisms, compositions and formulations that comprise the polypeptides, and methods of using the polypeptides, compositions and formulations.Type: GrantFiled: March 16, 2020Date of Patent: June 14, 2022Assignee: Axcella Health Inc.Inventors: Michael Hamill, Brett Boghigian, Caitlyn Harvey, David Berry, David Young, Geoffrey Von Maltzahn, John Kramarczyk, Jameson Rogers, Kathryn Heard, Michael Doherty, Nathaniel Silver, Phillip Samayoa, Subhayu Basu, Shaila Rahman, Vimal Vaidya, Ying-Ja Chen