Abstract: Hierarchical storage of files is described. An example method includes determining an input/output (IO) mode, a file size, and a file access frequency of a target file, and determining IO mode performances of the IO mode at different tiers of a storage system. The method further includes determining, based on the file size of the target file, respective storage costs when the target file is stored at the different tiers of the storage system. In addition, the method further includes determining a target tier at which the target file is stored based on the IO mode performances, the respective storage costs, the file size, and the file access frequency. In this way, it is possible to make full use of less expensive storage tiers and save the cost of the storage system, as well as to reduce the response time and improve the performance of the storage system.

Abstract: The present invention pertains to the pharmaceutical field, and particularly relates to a pharmaceutical combination comprising a Bcl-2 inhibitor or a Bcl-2/Bcl-xL inhibitor and one or more anticancer reagents, and the use of the combination to treat a disease such as cancer, specifically acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL) or multiple myeloma (MM) resistant or insensitive to Bcl-2 inhibitors and/or carrying Bcl-2 mutation and/or TP53 mutation. The invention also relates to a pharmaceutical composition or kit comprising the combination.

Abstract: A sensor may include a sensing element retained within a storage compartment filled with a storage medium, which may also be used as a calibration medium. The sensing element can include a sensing surface located away from the distal end of the sensing element, such that an inactive section of the sensing element can cooperate with a sealing member such as an O-ring to form part of the seal retaining the storage/calibration medium. The sensing element can be extended and retracted from the storage compartment to expose the sensing surface to a process medium, while preserving the storage medium within the storage compartment for post-measurement validation.

Abstract: An analog-to-digital converter is provided. An analog-to-digital converter comprises an interleaver receiving and processing an input signal that is an analog signal and a plurality of sub-ADCs, wherein the interleaver includes a reference circuit outputting a second voltage based on a first voltage, a high-pass filter receiving the second voltage and outputting a first signal obtained by changing a common mode voltage of the input signal to the second voltage, a sampling circuit generating a second signal obtained by sampling an alternate current component of the first signal, and a buffer outputting a third signal obtained by buffering the second signal by using a buffering circuit, and the sub-ADC converts the third signal into a digital signal by using the first voltage.

Abstract: Described herein are liquid, organosilicon compounds that including a substituent that is a cyano (—CN), cyanate (—OCN), isocyanate (—NCO), thiocyanate (—SCN) or isothiocyanate (—NCS). The organosilicon compounds are useful in electrolyte compositions and can be used in any electrochemical device where electrolytes are conventionally used.

Abstract: A heat exchange apparatus includes a heat exchanger, a refrigerant adjustment component, and a first connecting member. The heat exchanger includes a first pipe, a second pipe, a plurality of heat exchange tubes connecting the first pipe and the second pipe, and an edge plate located on an outer side of the plurality of heat exchange tubes in a length direction of the first pipe. At least part of the refrigerant adjustment component is located on an outer side of the edge plate in the length direction of the first pipe. An included angle between an axis in a length direction of at least part of an outer wall of the refrigerant adjustment component and an axis in the length direction of the first pipe is greater than 0° and less than or equal to 90°.

Abstract: The present disclosure relates to bifunctional compounds, which find utility to degrade (and inhibit) Androgen Receptor. In particular, the present disclosure is directed to compounds, which contain on one end a cereblon ligand which binds to the E3 ubiquitin ligase and on the other end a moiety which binds Androgen Receptor, such that Androgen Receptor is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of Androgen Receptor. The present disclosure exhibits a broad range of pharmacological activities associated with compounds according to the present disclosure, consistent with the degradation/inhibition of Androgen Receptor.

Abstract: A sensor may include a sensing element retained within a storage compartment filled with a storage medium, which may also be used as a calibration medium. The sensing element can be moved from a first position in which the sensing element is exposed to the storage compartment, and a second position in which the sensing element can be exposed to a process medium. An actuator mechanism may be configured to engage a portion of the sensor to move the sensing element between the first position and the second position. The actuator mechanism may be controlled by an external system, and may include a rotary actuator such as a servomotor or a stepper motor to move the sensing element between the first position and the second position.

Abstract: In various embodiments, a system can: access a failure image on which a first model has inaccurately performed an inferencing task; train, on a set of dummy images, a second model to learn a visual variety of the failure image, based on a loss function having a first term and a second term, the first term quantifying visual content dissimilarities between the set of dummy images and outputs predicted during training by the second model, and the second term quantifying, at a plurality of different image scales, visual variety dissimilarities between the failure image and the outputs predicted during training by the second model; and execute the second model on each of a set of training images on which the first model was trained, thereby yielding a set of first converted training images that exhibit the visual variety of the failure image.

Abstract: Systems and methods for authenticating a user for a service provider system. A database including a list of device identifiers is maintained in an authentication management system. A request to authenticate a user is received from a service provider system in an authentication management system. The request includes a device identification of the device associated with the user. It is determined that the device identification is included in the list of device identifiers and an authentication verification is transmitted to the service provider system in response to determining the device identification is included in the list of device identifiers.

Abstract: Systems and methods for authenticating a user for a service provider system. A request to authenticate a user is received from a service provider system in an authentication management system. An authentication request is transmitted from the authentication management system to a registered device associated with the user. An authentication confirmation is received from the registered device in the authentication management system. An authentication verification is provided to the service provider system in response to receiving the authentication confirmation.

Abstract: Systems and methods for authenticating a user for a service provider system. A request to authenticate a user is received from a service provider system in an authentication management system. An authentication request is transmitted from the authentication management system to a registered device associated with the user. An authentication confirmation is received from the registered device in the authentication management system. An authentication verification is provided to the service provider system in response to receiving the authentication confirmation.

Abstract: A door assembly includes a monolithic base including a top panel having a first end and a second end opposite the first end. The monolithic base includes an attachment panel extending downwardly from the first end at an acute angle. The monolithic base includes an outer panel extending downwardly from the second end.

Abstract: A door assembly includes a monolithic base including a top panel having a first end and a second end opposite the first end. The monolithic base includes an attachment panel extending downwardly from the first end at an acute angle. The monolithic base includes an outer panel extending downwardly from the second end.

Abstract: Methods and systems are provided for authenticating a user with a service provider by implementing an independent authentication management server along with its accompanying cross-platform device application installed on a user's device which provides, among other things, a secure and seamless exchange of sensitive data between a user and the service provider. An authentication management server system may further create, store, and manage a user's sensitive data and securely manage exchange of various requests and corresponding approvals between a user and the service provider.

Abstract: A vehicle side impact airbag has an inflator, a main inflatable chamber disposed for contact with the side arm of the vehicle occupant when inflated, and a separate laterally extending thoracic chamber in metered fluid communication with the main inflatable chamber of the side airbag extending laterally into the passenger compartment. The laterally extending thoracic chamber of the airbag is disposed for contact with the lower thoracic region of the vehicle occupant below the occupant side arm when inflated, whereby the side airbag simultaneously engages the occupant lower thoracic region and side arm when inflated.

Abstract: A vehicle side impact airbag has an inflator, a main inflatable chamber disposed for contact with the side arm of the vehicle occupant when inflated, and a separate laterally extending thoracic chamber in metered fluid communication with the main inflatable chamber of the side airbag extending laterally into the passenger compartment. The laterally extending thoracic chamber of the airbag is disposed for contact with the lower thoracic region of the vehicle occupant below the occupant side arm when inflated, whereby the side airbag simultaneously engages the occupant lower thoracic region and side arm when inflated.

Abstract: An integrated combined extended map pocket close-out and pelvic bolster component for attachment to a door trim substrate used in a vehicle door is disclosed. The component comprises a map pocket close-out portion, a pelvic bolster portion, and a bridge connecting the map pocket close-out portion and the pelvic bolster portion. The pelvic bolster portion is substantially hollow and preferably defines a box. The component includes a plurality of walls and the thickness of some of the walls is greater than the thickness of other walls. One or more of the walls may be angled. The map pocket close-out portion has a depth and the pelvic bolster portion has a depth. The depth of the map pocket close-out portion is greater than the depth of the pelvic bolster portion. The one-piece component is a molded component formed from a polymerized material.