Abstract: Bifunctional compounds, which find utility as modulators of leucine-rich repeat kinase 2 (LRRK2), are described herein. In particular, the hetero-bifunctional compounds of the present disclosure contain on one end a moiety that binds to the cereblon E3 ubiquitin ligase and on the other end a moiety which binds LRRK2, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The hetero-bifunctional compounds of the present disclosure exhibit a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aberrant regulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

Abstract: The pharmacokinetic profile of the SGLT2 inhibitor bexagliflozin can be improved by formulating it as an extended release tablet. Compared with standard immediate-release dosage forms these tablets can permit a lower peak plasma concentration, Cmax, while maintaining plasma concentrations at therapeutic levels for a desired period. This can be used, for instance, to administer lower doses while still providing the same pharmacological effect.

Abstract: Disclosed are compounds having the formula: wherein q, r, s, A, B, C, RA1, RA2, RB1, RB2, RC1, RC2, R3, R4, R5, R6, R14, R15, R16, and R17, are as defined herein, or a tautomer thereof, or a salt, particularly a pharmaceutically acceptable salt, thereof.

Abstract: The present disclosure relates to bifunctional compounds, which find utility as modulators of ?-synuclein (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a Von Hippel-Lindau, cereblon. Inhibitors of Apotosis Proteins or mouse double-minute homolog 2 ligand which binds to the respective E3 ubiquitin ligase and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

Abstract: Disclosed wherein stacked memory dies that utilize a mix of high and low operational temperature memory and non-volatile based memory dies, and chip packages containing the same. High temperature memory dies, such as those using non-volatile memory (NVM) technologies are in a memory stack with low temperature memory dies, such as those having volatile memory technologies. In some cases, the high temperature memory technologies could be used together, in some cases, on the same IC die as logic circuitry. In one example, a memory stack is provided that include a first memory IC die having high temperature memory circuitry, such as non-volatile memory, stacked below a second memory IC die. The second memory IC die has high temperature memory circuitry, such as volatile memory circuitry.

Abstract: Memory stacks having substantially vertical bitlines, and chip packages having the same, are disclosed herein. In one example, a memory stack is provided that includes a first memory IC die and a second memory IC die. The second memory IC die is stacked on the first memory IC die. Bitlines are routed through the first and second IC dies in a substantially vertical orientation. Wordlines within the first memory IC die are oriented orthogonal to the bitlines.

Abstract: A technique facilitates construction of a wire-wrapped screen. A wrapping machine is operated with a sensor, e.g. a camera, positioned adjacent the wrapping machine while wire is wrapped to create the wire-wrapped screen. The sensor is used to obtain data on at least one parameter of the wire-wrapped screen during creation of the wire-wrapped screen. Data is provided to a controller in communication with the wrapping machine to improve the quality of the wire-wrapped screen. For example, data from the images obtained via the camera may be provided to the controller which is configured to determine slot width as the wire is wrapped. The controller is then able to provide feedback in real time to the wrapping machine so as to adjust the wrapping machine for maintaining a desired slot width.

Abstract: Apparatus, methods, and systems for transducing measurements from medium of interest. One non-limiting example is in planta monitoring of plants. In one aspect, a micro- or nano-scale probe body includes one or more microprobes (e.g. microneedles or waveguides) to access desired plant tissue, and one or more microsensors on the probe body. A microcircuit on or in the probe body transduces relevant measurements from the microsensor(s). An output interface allows storage, communication, or transfer of the transduced measurement for further use. Non-limiting examples are processing into estimations of chemical concentrations or the like for biochemical sensing. As such, if used as in planta sensors, they can be minimally invasive and cost effective for both single use and use in sets for plural plants with one central station.

Abstract: Systems and methods for authenticating a user for a service provider system. A database including a list of device identifiers is maintained in an authentication management system. A request to authenticate a user is received from a service provider system in an authentication management system. The request includes a device identification of the device associated with the user. It is determined that the device identification is included in the list of device identifiers and an authentication verification is transmitted to the service provider system in response to determining the device identification is included in the list of device identifiers.

Abstract: Systems and methods for authenticating a user for a service provider system. A request to authenticate a user is received from a service provider system in an authentication management system. An authentication request is transmitted from the authentication management system to a registered device associated with the user. An authentication confirmation is received from the registered device in the authentication management system. An authentication verification is provided to the service provider system in response to receiving the authentication confirmation.

Abstract: Systems and methods for authenticating a user for a service provider system. A request to authenticate a user is received from a service provider system in an authentication management system. An authentication request is transmitted from the authentication management system to a registered device associated with the user. An authentication confirmation is received from the registered device in the authentication management system. An authentication verification is provided to the service provider system in response to receiving the authentication confirmation.

Abstract: A door assembly includes a monolithic base including a top panel having a first end and a second end opposite the first end. The monolithic base includes an attachment panel extending downwardly from the first end at an acute angle. The monolithic base includes an outer panel extending downwardly from the second end.

Abstract: A door assembly includes a monolithic base including a top panel having a first end and a second end opposite the first end. The monolithic base includes an attachment panel extending downwardly from the first end at an acute angle. The monolithic base includes an outer panel extending downwardly from the second end.

Abstract: Methods and systems are provided for authenticating a user with a service provider by implementing an independent authentication management server along with its accompanying cross-platform device application installed on a user's device which provides, among other things, a secure and seamless exchange of sensitive data between a user and the service provider. An authentication management server system may further create, store, and manage a user's sensitive data and securely manage exchange of various requests and corresponding approvals between a user and the service provider.

Abstract: A vehicle side impact airbag has an inflator, a main inflatable chamber disposed for contact with the side arm of the vehicle occupant when inflated, and a separate laterally extending thoracic chamber in metered fluid communication with the main inflatable chamber of the side airbag extending laterally into the passenger compartment. The laterally extending thoracic chamber of the airbag is disposed for contact with the lower thoracic region of the vehicle occupant below the occupant side arm when inflated, whereby the side airbag simultaneously engages the occupant lower thoracic region and side arm when inflated.

Abstract: A vehicle side impact airbag has an inflator, a main inflatable chamber disposed for contact with the side arm of the vehicle occupant when inflated, and a separate laterally extending thoracic chamber in metered fluid communication with the main inflatable chamber of the side airbag extending laterally into the passenger compartment. The laterally extending thoracic chamber of the airbag is disposed for contact with the lower thoracic region of the vehicle occupant below the occupant side arm when inflated, whereby the side airbag simultaneously engages the occupant lower thoracic region and side arm when inflated.

Abstract: An integrated combined extended map pocket close-out and pelvic bolster component for attachment to a door trim substrate used in a vehicle door is disclosed. The component comprises a map pocket close-out portion, a pelvic bolster portion, and a bridge connecting the map pocket close-out portion and the pelvic bolster portion. The pelvic bolster portion is substantially hollow and preferably defines a box. The component includes a plurality of walls and the thickness of some of the walls is greater than the thickness of other walls. One or more of the walls may be angled. The map pocket close-out portion has a depth and the pelvic bolster portion has a depth. The depth of the map pocket close-out portion is greater than the depth of the pelvic bolster portion. The one-piece component is a molded component formed from a polymerized material.

Abstract: An integrated combined extended map pocket close-out and pelvic bolster component for attachment to a door trim substrate used in a vehicle door is disclosed. The component comprises a map pocket close-out portion, a pelvic bolster portion, and a bridge connecting the map pocket close-out portion and the pelvic bolster portion. The pelvic bolster portion is substantially hollow and preferably defines a box. The component includes a plurality of walls and the thickness of some of the walls is greater than the thickness of other walls. One or more of the walls may be angled. The map pocket close-out portion has a depth and the pelvic bolster portion has a depth. The depth of the map pocket close-out portion is greater than the depth of the pelvic bolster portion. The one-piece component is a molded component formed from a polymerized material.