Abstract: The present disclosure relates inter alia to a new T-cell receptor (TCR), an immune cell, particularly a T-cell expressing said TCR; a vector encoding said TCR; a soluble version of said TCR; a pharmaceutical composition or bispecific comprising said TCR, and a method of treating cancer using said TCR, said cell, said vector, said pharmaceutical composition or bispecific comprising said TCR.

Abstract: The disclosed embodiments relate to systems/methods for data message matching in a peer-to-peer exchange system. Within the peer-to-peer exchange system, a dedicated processing instance attempts to match incoming data messages to resting message previously converted to the market data by other dedicated processing instances within the peer-to-peer exchange system. The market data stored within compartmentalized data structures on the dedicated processing instances. After establishing a preliminary match at the dedicated processing instance, the dedicated processing instance forwards the preliminary match to a global processing instance to attempt a confirmatory match.

Abstract: The present disclosure relates to systems, methods, and devices for controlling charging of vehicles, to avoid charging during charge-adverse time periods or during charge restriction events. This can advantageously reduce cost to vehicles owners, and or provide access to reward incentives. Further, power distribution entities (utility providers) advantageously have increased control over power distribution to avoid over-burdening of power distribution infrastructure. Further, systems and methods for determining or inferring whether a vehicle is connected to a charge station are described, which can be used to inform automatic restriction of vehicle charging.

Abstract: An endoscope system is provided with a graphical orientation indicator. An endoscope includes a flexible tubular body with a steerable distal end having a camera. A controller for the endoscope presents a user interface that displays a view from the camera and a graphical orientation indicator visually representing an orientation of the distal end of the endoscope.

Abstract: A system for energy conversion including a closed cycle engine containing a volume of working fluid is provided. The engine includes a double-ended piston assembly including a pair of pistons coupled to a connection member. An expansion chamber is separated from a compression chamber by the piston. The engine defines an outer end and an inner end relative to a lateral extension of the piston assembly. A heater body is positioned thermally proximal to the expansion chamber and thermally distal to the compression chamber, and the heater body is positioned at the outer end of the engine. A load device is operably coupled to the piston assembly at the inner end of the engine. The load device is positioned between the pair of pistons of the piston assembly.

Abstract: A wireless charging system for recharging batteries in a medical environment includes a charging station. The charging station may include an opening to receive batteries and an outlet for dispensing charged batteries, wherein the outlet comprises a slot in a front cover. The charging station also includes a wireless power transmitter having a transmitting antenna.

Abstract: Provided are novel Pyrazolopyrimidine Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and R4 are as defined herein. Also provided are compositions comprising at least one Pyrazolopyrimidine Derivative, and methods of using the Pyrazolopyrimidine Derivatives for treating or preventing a herpesvirus infection in a patient.

Abstract: A calibration apparatus for calibrating a laser Doppler vibrometer includes: a frequency shifter stage that: receives, from the laser Doppler vibrometer, primary laser light; produces frequency shifted light; communicates the frequency shifted light to a reflector; receives frequency shifted light reflected by the reflector; produces secondary light; and communicates the secondary light to the laser Doppler vibrometer, such that the laser Doppler vibrometer receives the secondary light from the frequency shifter stage and produces a synthetic velocity shift from the secondary light; and the reflector that receives and reflects the frequency shifted light back to the frequency shifter stage.

Abstract: In one embodiment, a method (236) of harvesting thermal energy and water from air, the method comprising: receiving a flow of water vapor containing air over a first heat exchanging contactor contained in a chamber in a non-sealed state, the first heat exchanging contactor coated with an adsorbent material that adsorbs water vapor (238); desorbing water vapor from a second adsorbent-coated heat exchanging contactor contained in a chamber in a sealed state under a partial vacuum (240); exchanging thermal energy between the first heat exchanging contactor and the second heat exchanging contactor, wherein heat gained by heat of adsorption in the first heat exchanging contactor transferred to heat the second heat exchanging contactor to aid desorption, wherein heat lost due to the heat of desorption in the second heat exchanging contactor is transferred to cool the first heat exchanging contactor to aid adsorption (242); drawing a vacuum in the sealed chamber to pull air out and desorb, compress, and heat the wat

Abstract: Computerized methods and apparatuses, including computer program products, for guided workflow processing include a server computing device which determines a guided workflow transaction path based upon input received from a first client device. The server initiates a transaction based upon the transaction path, including capturing data elements associated with a user of a second client device. The server stores the captured data elements, including a transaction identification token and a state of the transaction path. The server receives a request to continue the transaction from the second client device and retrieves the data elements. The server generates a user interface form based upon the state of the transaction path and displays the user interface form on the second client device. The server processes the transaction based upon input received from the second client device via the user interface form.

Abstract: Techniques for aligning image content are disclosed. The alignment occurs by concurrently identifying corner and line features and by aligning the images based on those features. As a result, relaxed constraints can be used during the alignment process as compared to constraints that are required when aligning images using only corner features. To achieve these benefits, first and second images are acquired. A first set of pixels that correspond to corner features are detected within the images. In parallel, a second set of pixels that correspond to line features are detected within the images. Image content is then aligned from the two images. The aligning process is performed using at least some of the pixels from the first and second sets.

Abstract: The present invention relates to compounds of formula I: in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Abstract: A heat exchanger is provided that can include furcating unit cells coupled with each other. Each of the unit cells can be elongated along an axis and include a sidewall that defines annular ring openings on opposite ends of the unit cell along the axis. The sidewall also can define undulating annular rings between the annular ring openings and axially separated from each other along the axis. The sidewall can further define angled openings into the unit cell both above and below each of the undulating annular rings. At least a first opening of the annular ring openings and the angled openings can be configured to be an inlet to receive a first fluid into the unit cell and at least a second opening of the annular ring openings and the angled openings configured to be an outlet through which the first fluid exits the unit cell.

Abstract: A system for obtaining color imagery using SPADs includes a SPAD array that has a plurality of SPAD pixels. Each of the plurality of SPAD pixels includes a respective color filter positioned thereover. The system is configurable to capture an image frame using the SPAD array and generate a filtered image by performing a temporal filtering operation using the image frame and at least one preceding image frame. The at least one preceding image frame is captured by the SPAD array at a timepoint that temporally precedes a timepoint associated with the image frame. The system is also configurable to, after performing the temporal filtering operation, generate a color image by demosaicing the filtered image.

Abstract: Implementations described and claimed herein provide systems and methods for evaporative cooling control. In one implementation, a humidity setpoint is received for a designated space, and at least one atmospheric condition of ambient air is received. The at least one atmospheric condition is measured using one or more ambient air sensors. A performance prediction of an evaporative cooler is generated by calculating a set of one or more predicted psychrometric properties of supply air leaving the evaporative cooler based on the at least one atmospheric condition. The humidity setpoint is compared to the set of one or more predicted psychrometric properties of the performance prediction in a setpoint comparison. A flow of fluid is controlled over evaporative media using one or more pumps of the evaporative cooler. The flow of the fluid is controlled based on the setpoint comparison such that the humidity setpoint is prevented from being exceeded.

Abstract: A system for facilitating intensity image capture and time of flight capture. The system includes an image sensor array comprising a plurality of image sensor pixels, one or more processors, and one or more hardware storage devices storing instructions that are executable by the one or more processors to configure the system to facilitate intensity image capture and time of flight capture by configuring the system to perform interleaved intensity image capture and time of flight capture operations using the image sensor array.

Abstract: A device includes an interface. The interface includes a plurality of terminals. The interface further includes first components configured to interpret signals received at the plurality of terminals according to a first protocol. The device further includes second components configured to the interpret signals received at the plurality of terminals according to a second protocol. The first components are configured to disable the second components in response to a determination that the signals received at the terminals correspond to the first protocol. Further, the second components are configured to disable the first components in response to a determination that the signals received at the terminals correspond to the second protocol.