Abstract: The present invention relates to compounds of formula I: in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Abstract: Implementations described and claimed herein provide systems and methods for evaporative cooling control. In one implementation, a humidity setpoint is received for a designated space, and at least one atmospheric condition of ambient air is received. The at least one atmospheric condition is measured using one or more ambient air sensors. A performance prediction of an evaporative cooler is generated by calculating a set of one or more predicted psychrometric properties of supply air leaving the evaporative cooler based on the at least one atmospheric condition. The humidity setpoint is compared to the set of one or more predicted psychrometric properties of the performance prediction in a setpoint comparison. A flow of fluid is controlled over evaporative media using one or more pumps of the evaporative cooler. The flow of the fluid is controlled based on the setpoint comparison such that the humidity setpoint is prevented from being exceeded.

Abstract: A system for obtaining color imagery using SPADs includes a SPAD array that has a plurality of SPAD pixels. Each of the plurality of SPAD pixels includes a respective color filter positioned thereover. The system is configurable to capture an image frame using the SPAD array and generate a filtered image by performing a temporal filtering operation using the image frame and at least one preceding image frame. The at least one preceding image frame is captured by the SPAD array at a timepoint that temporally precedes a timepoint associated with the image frame. The system is also configurable to, after performing the temporal filtering operation, generate a color image by demosaicing the filtered image.

Abstract: A heat exchanger is provided that can include furcating unit cells coupled with each other. Each of the unit cells can be elongated along an axis and include a sidewall that defines annular ring openings on opposite ends of the unit cell along the axis. The sidewall also can define undulating annular rings between the annular ring openings and axially separated from each other along the axis. The sidewall can further define angled openings into the unit cell both above and below each of the undulating annular rings. At least a first opening of the annular ring openings and the angled openings can be configured to be an inlet to receive a first fluid into the unit cell and at least a second opening of the annular ring openings and the angled openings configured to be an outlet through which the first fluid exits the unit cell.

Abstract: A system for facilitating intensity image capture and time of flight capture. The system includes an image sensor array comprising a plurality of image sensor pixels, one or more processors, and one or more hardware storage devices storing instructions that are executable by the one or more processors to configure the system to facilitate intensity image capture and time of flight capture by configuring the system to perform interleaved intensity image capture and time of flight capture operations using the image sensor array.

Abstract: A device includes an interface. The interface includes a plurality of terminals. The interface further includes first components configured to interpret signals received at the plurality of terminals according to a first protocol. The device further includes second components configured to the interpret signals received at the plurality of terminals according to a second protocol. The first components are configured to disable the second components in response to a determination that the signals received at the terminals correspond to the first protocol. Further, the second components are configured to disable the first components in response to a determination that the signals received at the terminals correspond to the second protocol.

Abstract: A computer-implemented method includes accessing data descriptive of a plurality of freight lanes, each freight lane being associated with a pickup region and a dropoff region for one or more loads, wherein each of the plurality of freight lanes includes one or more lane attributes; determining that two or more freight lanes of the plurality of freight lanes satisfy at least one clustering criteria indicative of a similarity between the two or more freight lanes based at least in part on the one or more freight lane attributes; in response to determining that the two or more freight lanes meet the at least one clustering criteria, clustering the two or more freight lanes to generate a clustered freight lane including the two or more freight lanes; receiving a request from a carrier computing device to associate a carrier with the clustered freight lane; and assigning at least one load of the one or more loads associated with the two or more freight lanes including the clustered freight lane to the carrier bas

Abstract: The present disclosure relates to systems, methods, and devices for controlling charging of vehicles, to avoid charging during charge-adverse time periods or during charge restriction events. This can advantageously reduce cost to vehicles owners, and or provide access to reward incentives. Further, power distribution entities (utility providers) advantageously have increased control over power distribution to avoid over-burdening of power distribution infrastructure. Further, systems and methods for determining or inferring whether a vehicle is connected to a charge station are described, which can be used to inform automatic restriction of vehicle charging.

Abstract: Systems and methods for controlling a radiofrequency (RF) treatment are provided. In some embodiments, the method can include: performing, using a programmable controller, at least the following functions of: measuring an electrical energy flow through a grounding pad that is in contact with at least a portion of skin of a subject's skin; determining, based on the measured electrical energy flow, a heating factor that represents a measure of heat absorbed by the subject over a period of time in response to treatment of the subject with an electrical radiofrequency probe; and comparing the heating factor to a predetermined threshold. In response to determining from the comparison that the heating factor is approaching or greater than the predetermined threshold value, the method can include disabling the radiofrequency generator or changing the electrical energy flow such that the controller regulates the electrical energy flow using a closed loop feedback system.

Abstract: Systems and methods for testing a pump assembly for a cooled radiofrequency treatment procedure. In some embodiments, the pump assembly and at least one pump head are driven by at least one respective motor, where the at least one pump head is coupled to tubing for delivering a cooling fluid to a medical probe assembly. The at least one pump head is configured to pump the cooling fluid through the tubing for the cooled radiofrequency treatment procedure. The system can also include a programmable controller operatively connective to the pump assembly and configured to control the pump assembly, and one or more pump function sensors for sensing operation parameters associated with the pump assembly and communicating the pump operation parameters to the controller. The controller can determine that the pump assembly is operating properly based on the operation parameters and can adjust the operation of the motor or output an alert.

Abstract: A balloon catheter has a shaft having a Y-connector provided at the proximal end, and a balloon provided at the distal end, the balloon having a balloon body having opposing first and second ends, and a reinforcement fiber layer wrapped on the balloon body, the fiber layer formed from a single continuous fiber wrapped first radially around the balloon body in non-continuous rows, followed by a figure-8 wrap that continuously traverses from the first end to the second end, and the second end back to the first end.

Abstract: A device includes an interface. The interface includes a plurality of pins. The interface further includes first components configured to interpret signals received at the plurality of pins according to a first protocol. The device further includes second components configured to the interpret signals received at the plurality of pins according to a second protocol. The first components are configured to disable the second components in response to a determination that the signals received at the pins correspond to the first protocol. Further, the second components are configured to disable the first components in response to a determination that the signals received at the pins correspond to the second protocol.

Abstract: Described herein are compositions, and more particularly to alloy compositions, methods of using the alloy compositions, and articles formed from with the alloy compositions. The alloy compositions are broadly applicable in applications requiring superalloys, including welding processes, additive manufacturing processes, metal casting processes, coating processes, repairing processes, powder metallurgy, and/or combinations thereof.

Abstract: Compositions, and articles and methods for forming articles which include said compositions, are disclosed. The compositions include, by weight percent, 13.7% to 14.3% chromium (Cr), 9.0% to 9.9% cobalt (Co), 4.0% to 5.5% aluminum (Al), 0.5% to 3.0% titanium (Ti), 3.5% to 5.0% tungsten (W), 1.4% to 4.0% molybdenum (Mo), 1.8% to 4.2% niobium (Nb), 0.08% to 0.12% carbon (C), 0.005% to 0.04% zirconium (Zr), 0.010% to 0.014% boron (B), and balance nickel (Ni) and incidental impurities.

Abstract: A computer-implemented method includes accessing data descriptive of a plurality of freight lanes, each freight lane being associated with a pickup region and a dropoff region for one or more loads, wherein each of the plurality of freight lanes includes one or more lane attributes; determining that two or more freight lanes of the plurality of freight lanes satisfy at least one clustering criteria indicative of a similarity between the two or more freight lanes based at least in part on the one or more freight lane attributes; in response to determining that the two or more freight lanes meet the at least one clustering criteria, clustering the two or more freight lanes to generate a clustered freight lane including the two or more freight lanes; receiving a request from a carrier computing device to associate a carrier with the clustered freight lane; and assigning at least one load of the one or more loads associated with the two or more freight lanes including the clustered freight lane to the carrier bas

Abstract: Aspects are described herein that are capable of providing a vehicle configuration for a vehicle that is optimized to maximize the customer's performance priorities while additionally complying with regulatory emissions requirements and equipment regulations. A machine learning (ML) predictive model is trained based on simulations run on combinations of vehicle configurations and routes and on real-world telematics data, and used to determine a vehicle configuration optimized for a representative route.