Patents by Inventor Michael Dubrovsky

Michael Dubrovsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11891643
    Abstract: Aspects relate to systems and methods for high-contrast cleavage detection. An exemplary method includes a plurality of probes, wherein at least a probe of the plurality of probes comprises a high-contrast agent, a waveguide configured to propagate an electromagnetic (EM) wave, wherein the waveguide includes a surface upon which the plurality of probes are immobilized, wherein the surface is configured to provide communication between the EM wave and the high-contrast agent, a primary cleaving agent proximal the plurality of probes, wherein the primary cleaving agent and the plurality of probes are configured to selectively cleave the at least a probe as a result of the primary cleaving agent being in presence of an analyte, and a sensor in communication with the waveguide and configured to detect cleaving of the at least a probe by way of the EM wave.
    Type: Grant
    Filed: June 3, 2021
    Date of Patent: February 6, 2024
    Inventor: Michael Dubrovsky
  • Publication number: 20240004417
    Abstract: An apparatus for combined digital and optical processing of a cryptocurrency data block includes a digital processor that computes a hash vector from the cryptocurrency data block; a laser and splitter that produces optical input signals; optical modulators that binary phase-shift key modulate the optical input signals based on the hash vector; a photonic matrix multiplier circuit that performs an optically perform a discrete matrix-vector product operation on the modulated optical input signals to produce optical output signals, where the discrete matrix-vector product operation is defined by matrix elements limited to K discrete values, where 2?K?17; and photodetectors and comparators that perform optoelectronic conversions of the optical output signals to produce corresponding digital electronic output signals. The digital processor performs a second hash computation on an XOR result between the digital electronic output signals and the hash vector to produce a proof of work result.
    Type: Application
    Filed: March 25, 2023
    Publication date: January 4, 2024
    Inventors: Sunil K. Pai, David A.B. Miller, Olav Solgaard, Shanhui Fan, Michael Dubrovsky, Bogdan Penkovsky, Maynard Marshall Ball, JR.
  • Publication number: 20230393143
    Abstract: Disclosed herein are methods of allergen testing and IgG depletion. In some embodiments, testing for IgE antibodies specific for an allergen may be improved by first depleting IgG in a sample. In some embodiments, IgG may be depleted using Biotinylated Protein G (bPG) and streptavidin (SA).
    Type: Application
    Filed: May 18, 2023
    Publication date: December 7, 2023
    Applicant: SiPhox, Inc.
    Inventors: Michael Dubrovsky, Eric Hsu, Elaine Taine, Xabier Arias, Yulia Rybakova
  • Publication number: 20230384319
    Abstract: An apparatus for detecting an analyte, the apparatus includes a biosensor having at least a sensor surface functionalized with a binding ligand, wherein the at least a sensor surface is configured to selectively bind to an analyte, a microfluidic device configured to receive a sample fluid containing the analyte, incubate the biosensor with the sample fluid, and conjugate an anti-analyte molecule with a nanoparticle, wherein the nanoparticle is configured to provide a binding signal to the biosensor when the nanoparticle binds to the analyte bound to the binding ligand on the at least a sensor surface, and incubate the biosensor with the analyte bound to the binding ligand on the at least a sensor surface with the anti-analyte molecule conjugated with the nanoparticle, and a sensor circuit communicatively connected to the biosensor, wherein the sensor circuit is configured to detect at least an analyte characteristic of the analyte.
    Type: Application
    Filed: May 18, 2023
    Publication date: November 30, 2023
    Applicant: SiPhox, Inc.
    Inventors: Michael Dubrovsky, Eric Hsu, Elaine Taine, Xabier Arias, Yulia Rybakova
  • Publication number: 20230371869
    Abstract: Apparatus of a multipurpose fluid extraction device for diagnostics and method of use are disclosed. The apparatus includes a fluid extraction system, wherein the fluid extraction system is configured to extract a fluid from a user, a microfluidic assembly, wherein the microfluidic assembly is configured to provide a flow of extracted fluid, where the microfluidic assembly includes a microfluidic channel, a photonic sensor, wherein the photonic sensor is configured to output a sensor signal to a reader device that is configured to detect one or more characteristics of the extracted fluid as a function of the sensor signal, an assay component fluidically connected to the microfluidic assembly, wherein the assay component is configured for testing the extracted fluid and a fluid collecting reservoir fluidically connected to the microfluidic assembly, wherein the fluid collecting reservoir is configured to collect the extracted fluid from the microfluidic assembly.
    Type: Application
    Filed: May 18, 2023
    Publication date: November 23, 2023
    Applicant: SiPhox, Inc.
    Inventors: Michael Dubrovsky, Diedrik Rene Vermeulen
  • Publication number: 20230372934
    Abstract: An apparatus for controlling assay steps using active flow components, the apparatus includes a microfluidic device containing a reservoir configured to contain a fluid and microfluidic channels connected to the reservoir, wherein the microfluidic channels are configured to create a microfluidic environment for an assay, active flow components, a sensor device configured to detect a sensed property of the fluid, and an external device connected to the microfluidic device including actuators, wherein the actuators are configured to connect the active flow components using a mechanical interface and initiate active flow processes corresponds to assay steps of the assay based on the active flow components, and a reading device configured to read the sensed property of the fluid from the sensor device, wherein the active flow components are configured to flow the fluid bi-directionally through the sensor device within the microfluidic environment based on active flow processes.
    Type: Application
    Filed: May 18, 2023
    Publication date: November 23, 2023
    Applicant: SiPhox, Inc.
    Inventors: Michael Dubrovsky, Armando Paredes, Diedrik Rene Vermeulen
  • Publication number: 20230272456
    Abstract: The invention relates generally to systems and methods for assaying a biological sample suspected of comprising a target biomolecule using cascading amplification.
    Type: Application
    Filed: June 3, 2021
    Publication date: August 31, 2023
    Inventor: Michael Dubrovsky
  • Publication number: 20230236373
    Abstract: Systems and methods for coupling photonic integrated subcircuits are described herein. The example system can include a first cartridge (4702) including a first photonic integrated subcircuit (4706) and a first alignment feature (4720, 4722). The system can include a second cartridge (4704) including a second photonic integrated subcircuit (4708) and a second alignment feature (4724, 4726), where the first alignment feature (4720, 4722) and the second alignment feature (4724, 4726) can be configured to enable alignment between the first photonic integrated subcircuit (4706) and the second photonic integrated subcircuit (4708). When the first photonic integrated subcircuit (4706) is aligned to the second photonic integrated subcircuit (4708), a first light path of the first photonic integrated subcircuit (4706) can be optically coupled to a second light path of the second photonic integrated subcircuit (4708).
    Type: Application
    Filed: June 4, 2021
    Publication date: July 27, 2023
    Inventors: Diedrik Rene Vermeulen, Michael Whitson, Michael Dubrovsky, Azra Horowitz
  • Publication number: 20230186005
    Abstract: Systems and methods for generating a virtual environment for implementing an integrated photonics assembly are presented. An example system can include one or more processors and a memory coupled with the processors, where the processor executes a plurality of modules stored in the memory. The plurality of modules can include a user interface module for deploying one or more virtual photonic integrated subcircuits within the virtual environment, in which the virtual environment is configured to enable coupling of at least two virtual photonic integrated subcircuits. The coupling of the virtual photonic integrated subcircuits can form a virtual integrated photonics assembly. The modules can include a library module comprising a plurality of virtual photonic integrated subcircuits. One or more virtual photonic integrated subcircuits can include a performance characteristic.
    Type: Application
    Filed: April 29, 2021
    Publication date: June 15, 2023
    Inventors: Diedrik Rene Vermeulen, Michael Dubrovsky
  • Publication number: 20230133866
    Abstract: Disclosed herein are integrated photonics systems (3800) for biosensing including an interrogator photonic circuit (3802) and cartridge (3804) and methods using these systems. The cartridge (3804) comprises a sensor photonic integrated subcircuit. The cartridge (3804) is configured to receive a biological sample. The interrogator photonic circuit (3802) is optically coupled to the cartridge (3804) an comprises: (i) a light source (3806) configured to generate light; and (ii) one or more waveguides configured to carry the light, wherein the light is used to determine a characteristic of the biological sample in the cartridge (3804). A system can have an assembly of a plurality of modular photonic integrated subcircuits. Each subcircuit can be pre-fabricated and can be configured to transfer light to and receive light from another subcircuit based on the first functionality.
    Type: Application
    Filed: April 9, 2021
    Publication date: May 4, 2023
    Inventors: Diedrik Rene Vermeulen, Michael Dubrovsky, Sarat Gundararapu
  • Publication number: 20230012094
    Abstract: Aspects relate to systems and methods for fluid sensing using passive flow. An exemplary system includes a microfluidic device, the microfluidic device including at least a reservoir configured to contain at least a fluid and at least a passive flow component in fluidic communication with the at least a reservoir and configured to flow the at least a fluid with predetermined flow properties, at least an sensor device configured to be in sensed communication with the at least a fluid and detect at least a sensed property; and at least an sensor interface configured to wet at least a surface of the at least a sensor device with the at least a fluid.
    Type: Application
    Filed: July 7, 2022
    Publication date: January 12, 2023
    Applicant: SiPhox, Inc.
    Inventors: Michael Dubrovsky, Pengguan Yu, Diedrik Rene Vermeulen
  • Publication number: 20220049298
    Abstract: A method of tagged-base DNA sequencing readout on waveguide surfaces includes immobilizing, a surface of a waveguide, a nucleotide fragment, exposing the nucleotide fragment to a first plurality of capped nucleotides, wherein the first plurality of capped nucleotides include a first plurality of nucleotide types, each distinct nucleotide type has a distinct capping agent, and each distinct capping agent has a distinct optical signature, severing base pair connections between the at least a nucleotide fragment and the first plurality of capped nucleotides, wherein the nucleotide fragment remains attached and a first single nucleotide, of the first plurality of capped nucleotides, remains immobilized on a nucleotide binding locus adjacent to the first nucleotide sequence, and detecting a first distinct optical signature of a first distinct capping agent of the first single nucleotide using the waveguide.
    Type: Application
    Filed: August 16, 2021
    Publication date: February 17, 2022
    Applicant: SiPhox, Inc.
    Inventors: Michael Dubrovsky, Diedrik Rene Vermeulen
  • Publication number: 20210382515
    Abstract: Aspects relate to methods and systems for optical matrix calculation. An exemplary system includes at least a first light source configured to output at least a first optical output having a first wavelength, at least a second light source configured to output at least a second optical output having a second wavelength substantially different from the first wavelength, at least an optical modulator configured to modulate the at least a first optical output, at least an optical matrix multiplier configured to perform at least two matrix multiplications, a first matrix multiplication as a function of the first optical output and a second matrix multiplication as a function of the second optical output, and at least a photodetector configured to measure the at least a first optical output and the at least a second optical output.
    Type: Application
    Filed: June 3, 2021
    Publication date: December 9, 2021
    Applicant: SiPhox, Inc.
    Inventors: Michael Dubrovsky, Diedrik Rene Vermeulen
  • Publication number: 20210381018
    Abstract: Aspects relate to systems and methods for high-contrast cleavage detection. An exemplary method includes a plurality of probes, wherein at least a probe of the plurality of probes comprises a high-contrast agent, a waveguide configured to propagate an electromagnetic (EM) wave, wherein the waveguide includes a surface upon which the plurality of probes are immobilized, wherein the surface is configured to provide communication between the EM wave and the high-contrast agent, a primary cleaving agent proximal the plurality of probes, wherein the primary cleaving agent and the plurality of probes are configured to selectively cleave the at least a probe as a result of the primary cleaving agent being in presence of an analyte, and a sensor in communication with the waveguide and configured to detect cleaving of the at least a probe by way of the EM wave.
    Type: Application
    Filed: June 3, 2021
    Publication date: December 9, 2021
    Applicant: SiPhox, Inc.
    Inventor: Michael Dubrovsky
  • Publication number: 20170341525
    Abstract: The Anti-idling System for Ambulances and Other Vehicles is a novel system for making electricity available to vehicles which idle curbside in urban and suburban environments. The invention comprises a pedestal with a specialized electricity plug, a cord and cord reel, an onboard microcontroller with GSM and RFID card reader which controls the flow of electricity and communicates with a cloud-based management system, and a cloud-based management system which controls user authentication. This enables an ambulance or other vehicle operator to approach the pedestal, access the plug and cord and turn on the flow of electricity using an RFID card or mobile phone, and use the pedestal to power their vehicle while in proximity to the pedestal. When the vehicle engine is started, the system detects the auto-ejection of the plug from the vehicle, turns off the flow of electricity, and automatically retracts the plug and cord into the pedestal.
    Type: Application
    Filed: August 17, 2017
    Publication date: November 30, 2017
    Inventors: Michael Dubrovsky, Cody Rickman, Azra Horowitz, Yelizaveta Kholodkova, Tome Rey Verissimo, Jeffrey Hoffman
  • Patent number: 9776525
    Abstract: The Anti-idling System for Ambulances and Other Vehicles is a novel system for making electricity available to vehicles which idle curbside in urban and suburban environments. The invention comprises a pedestal with a specialized electricity plug, a cord and cord reel, an onboard microcontroller with GSM and RFID card reader which controls the flow of electricity and communicates with a cloud-based management system, and a cloud-based management system which controls user authentication. This enables an ambulance or other vehicle operator to approach the pedestal, access the plug and cord and turn on the flow of electricity using an RFID card or mobile phone, and use the pedestal to power their vehicle while in proximity to the pedestal. When the vehicle engine is started, the system detects the auto-ejection of the plug from the vehicle, turns off the flow of electricity, and automatically retracts the plug and cord into the pedestal.
    Type: Grant
    Filed: September 2, 2014
    Date of Patent: October 3, 2017
    Assignee: Move Systems International, LLC
    Inventors: Michael Dubrovsky, Cody Rickman, Azra Horowitz, Yelizaveta Kholodkova, Tome Rey Verissimo, Jeffrey Hoffman
  • Publication number: 20160059804
    Abstract: The Anti-idling System for Ambulances and Other Vehicles is a novel system for making electricity available to vehicles which idle curbside in urban and suburban environments. The invention comprises a pedestal with a specialized electricity plug, a cord and cord reel, an onboard microcontroller with GSM and RFID card reader which controls the flow of electricity and communicates with a cloud-based management system, and a cloud-based management system which controls user authentication. This enables an ambulance or other vehicle operator to approach the pedestal, access the plug and cord and turn on the flow of electricity using an RFID card or mobile phone, and use the pedestal to power their vehicle while in proximity to the pedestal. When the vehicle engine is started, the system detects the auto-ejection of the plug from the vehicle, turns off the flow of electricity, and automatically retracts the plug and cord into the pedestal.
    Type: Application
    Filed: September 2, 2014
    Publication date: March 3, 2016
    Inventors: Michael Dubrovsky, Cody Rickman, Azra Horowitz, Yelizaveta Kholodkova, Tomé Rey Veríssimo, Jeffrey Hoffman
  • Patent number: 8834725
    Abstract: A process for treating acid mine drainage containing heavy metals and soluble contaminants is provided. In one embodiment, at least a metal cation is added to the acid mine drainage at a pre-select pH to form insoluble heavy metal complexes. In one embodiment, the metal cation is a trivalent metal ion, e.g., ferric iron such as in ferric sulfate. In another embodiment, a divalent metal ion such as in ferrous sulfate is used. After the removal of the heavy metal complexes, the effluent water is treated with at least a phosphate additive to remove remaining soluble contaminants, thus producing a treated water stream with reduced levels of contaminants.
    Type: Grant
    Filed: January 31, 2011
    Date of Patent: September 16, 2014
    Assignee: Chevron U.S.A. Inc.
    Inventors: Rahul Shankar Bhaduri, Alexander Kuperman, Michael Dubrovsky
  • Patent number: 8449931
    Abstract: The present invention relates to a chewing gum base formulation comprising a biocompatible particulate polymer having an average particle size of from about 200 ?m to about 2000 ?m wherein the polymer fibrillates when subjected to a shear stress such as that encountered during chewing.
    Type: Grant
    Filed: August 28, 2006
    Date of Patent: May 28, 2013
    Inventor: Michael Dubrovsky
  • Publication number: 20120193296
    Abstract: A process for treating acid mine drainage containing heavy metals and soluble contaminants is provided. In one embodiment, at least a metal cation is added to the acid mine drainage at a pre-select pH to form insoluble heavy metal complexes. In one embodiment, the metal cation is a trivalent metal ion, e.g., ferric iron such as in ferric sulfate. In another embodiment, a divalent metal ion such as in ferrous sulfate is used. After the removal of the heavy metal complexes, the effluent water is treated with at least a phosphate additive to remove remaining soluble contaminants, thus producing a treated water stream with reduced levels of contaminants.
    Type: Application
    Filed: January 31, 2011
    Publication date: August 2, 2012
    Inventors: Rahul Shankar Bhaduri, Alexander Kuperman, Michael Dubrovsky