Abstract: A cutting and scrap ejector system for a panel includes a lower post, a main pad, a cutting member and a plunger. The main pad is configured to cooperate with the lower post to grip the panel. The cutting member is movable between a non-cutting position in which the cutting member is configured to be spaced apart from the panel and a cutting position in which the cutting member is configured to trim the panel. The plunger is movably coupled to the main pad between a first position in which the plunger is configured to be spaced apart from the panel and a second position in which the plunger is configured to contact a portion of the panel to eject the portion of the panel from the system. The plunger is inhibited from contacting the portion of the panel prior to the cutting member being moved to the cutting position.

Abstract: A system and method to train one or more components of a search algorithm based on feedback received from a user system. The system and method provide, via an interface, a first search query comprising one or more terms and a first query response generated by a component of the search algorithm. The system and method receive, via the interface, a label corresponding to the query response. An override action is generated in view of the label. In response to a second query comprising the one or more terms, generating a second query response in accordance with the override action.

Abstract: Compositions and methods related to the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) including viral pneumonia through the pharmaceutical manipulation of calcium signaling are disclosed. Such compositions and methods may be used to reduce pro-inflammatory cytokine releases that may lead to ALI and/or ARDS.

Abstract: Provided herein is an improved synthetic method for the production of CRAC channel inhibitors. The synthetic method provides a method for producing highly pure CRAC channel inhibitors for clinical testing.

Abstract: A method for fabricating a resorbable scaffold for regeneration of meniscal tissue is disclosed. The method includes fabricating a polymer filament network using 3D printing in accordance with a digital model of the polymer filament network, such that the polymer filament network will include a first plurality of layers comprising the circumferentially-oriented filaments alternating with a second plurality of layers comprising the radially-oriented filaments, the polymer filament network having a three-dimensional shape and geometry between a first layer and a second layer which is substantially the same as a three-dimensional shape and geometry of the resorbable scaffold.

Abstract: Compositions and methods related to the treatment of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) including viral pneumonia through the pharmaceutical manipulation of calcium signaling are disclosed. Such compositions and methods may be used to reduce pro-inflammatory cytokine releases that may lead to ALI and/or ARDS.

Abstract: A system and method to receive a search query input from an end user system, wherein the search query input relates to information associated with a merchant system. In view of the search query, a document associated with the merchant system is identified. A set of portions of the document are identified. A keyword-matching density level is determined for each portion of the set of portions of the document. A selected portion of the set of portions having a highest relative keyword-matching density level is identified. A graphical user interface including a search result responsive to the search query is generated, the graphical user interface including the selected portion of the document.

Abstract: A system and method to receive a search query input from an end user system, wherein the search query input relates to information associated with a merchant system. In view of the search query, a document associated with the merchant system is identified. A set of portions of the document are identified. A keyword-matching density level is determined for each portion of the set of portions of the document. A selected portion of the set of portions having a highest relative keyword-matching density level is identified. A graphical user interface including a search result responsive to the search query is generated, the graphical user interface including the selected portion of the document.

Abstract: A system and method to generate search results in response to a search query based on comparisons of embedding vectors. The system and method receive, from an end user system, a search query including a set of keywords associated with the entity. Using a neural network, an embedding vector is identified based on the set of keywords of the search query. The system and method compares the embedding vector associated with the search query to a set of embedding vectors associated with a set of structured data elements relating to the entity. Based on the comparison, a set of matching structured data elements is identified. The system and method generate a search result in response to the search query, wherein the search result includes at least a portion of the set of matching structured data elements. The search result is displayed via an interface of the end user system.

Abstract: Compositions and methods related to the amelioration of pancreatitis through the pharmaceutical manipulation of calcium signaling are disclosed. Such compositions and methods may be used to ameliorate symptoms of acute or chronic pancreatitis or to reduce the chance or severity of pancreatitis in an individual at risk of the condition. In other embodiments, disclosed herein are compositions and methods related to the amelioration of viral diseases through the pharmaceutical manipulation of calcium signaling. In further embodiments, disclosed herein are compositions and methods related to the amelioration of Th17-induced diseases through the pharmaceutical manipulation of calcium signaling.

Abstract: A system and method to generate search results in response to a search query based on comparisons of embedding vectors. The system and method receive, from an end user system, a search query including a set of keywords associated with the entity. Using a neural network, an embedding vector is identified based on the set of keywords of the search query. The system and method compares the embedding vector associated with the search query to a set of embedding vectors associated with a set of structured data elements relating to the entity. Based on the comparison, a set of matching structured data elements is identified. The system and method generate a search result in response to the search query, wherein the search result includes at least a portion of the set of matching structured data elements. The search result is displayed via an interface of the end user system.

Abstract: Methods are provided for the synthesis of a compound of formula (X). R2 is selected from —H, —C1-C4-alkyl, —C2-C4-alkenyl and C1-C4-aryl; R3 is selected from —C(O)H and —C(O)C1-C4-alkyl; and A is a pharmaceutically acceptable anion (e.g. a halide). Also provided are intermediate compounds formed during the synthesis.

Abstract: A system and method to receive a search query including a set of search terms associated with a merchant system. A machine-learning model is executed to identify a first subset of one or more multi-term phrases associated with one or more named entity types. A set of tokens corresponding to the search query is generated, wherein the set of tokens comprises a token associated with each of the first subset of one or more multi-term phrases. A comparison of the set of tokens to a document index associated with the merchant system is executed to identify one or more matching documents. Based on the comparison, a set of search results comprising the one or more matching documents is generated.

Abstract: Apparatus and associated methods relate to a pick & place system that uses a magnetic core for both magnetic coupling with an assembly component and heating of the assembly component. The magnetic core has a component engagement surface configured to magnetically and thermally engage the component. A controller is configured to provide both AC current and DC current to an inductive coil wound about the magnetic core. DC current provided to the inductive coil induces a magnetic field within the magnetic core, thereby magnetically attracting the component when engaged with the component engagement surface. AC current provided to the magnetic core inductively heats the magnetic core, thereby heating the component when engaged with the component engagement surface.

Abstract: Provided herein are pharmaceutical compositions, such as emulsions and nanosuspensions, comprising a CRAC channel inhibitor. Also provided herein are methods of treating pancreatitis, viral infections, stroke, traumatic brain injury, fibrosis, inflammation, and autoimmune diseases by administering such pharmaceutical compositions.

Abstract: Provided herein is an improved synthetic method for the production of CRAC channel inhibitors. The synthetic method provides a method for producing highly pure CRAC channel inhibitors for clinical testing.

Abstract: A locking plate for a locking arrangement includes a body that is defined by a first planar surface and a second planar surface that is opposite the first planar surface. The body has an arcuate shape that extends from a first lateral end to a second lateral end and extends from a radially inward facing edge to a radially outward facing edge. A single elongated curved opening extends through the body from the first planar surface to the second planar surface and extends an intermediate arc length in the body. An anti-rotation feature extends radially inward from the radially inward facing edge. The body has an anti-tilt lobe located proximate one or more of the first lateral end and the second lateral end.

Abstract: Compositions and methods related to the amelioration of pancreatitis through the pharmaceutical manipulation of calcium signaling are disclosed. Such compositions and methods may be used to ameliorate symptoms of acute or chronic pancreatitis or to reduce the chance or severity of pancreatitis in an individual at risk of the condition. In other embodiments, disclosed herein are compositions and methods related to the amelioration of viral diseases through the pharmaceutical manipulation of calcium signaling. In further embodiments, disclosed herein are compositions and methods related to the amelioration of Th17-induced diseases through the pharmaceutical manipulation of calcium signaling.

Abstract: The present disclosure provides monoclonal antibodies that bind to the natriuretic peptide receptor 1 (NPR1) protein, and methods of use thereof. In various embodiments of the disclosure, the antibodies are fully human antagonist antibodies that bind to NPR1. In some embodiments, the antibodies of the disclosure are useful for blocking NPR1 signaling and/or activity, thus providing a means of treating or preventing a disease, disorder, or condition associated with NPR1, including hypotension, in humans.

Abstract: Compositions and methods related to the treatment of acute kidney injury (AKI) through the pharmaceutical manipulation of calcium signaling are disclosed. Such compositions and methods may be used to reduce inflammatory responses that may lead to AKI, or the progression of AKI to CKD.