Abstract: The present disclosure relates to bilayer tablets comprising a second layer comprising a ?-lactam compound or a pharmaceutically acceptable salt thereof; and a first layer comprising probenecid or a pharmaceutically acceptable salt thereof. The present disclosure also relates to methods of treating or preventing a disease using the bilayer tablets.

Abstract: Disclosed herein are systems and methods for locating submerged items using a ropeless fishing system. A surface subsystem installed on a vessel is configured to generate and omnidirectionally transmit an acoustic interrogation signal into a body of water and to directionally receive acoustic reply signals. A plurality of submerged subsystems, each including an underwater acoustic actuator-transponder unit, are configured to receive the interrogation signal and transmit reply signals in response. The surface subsystem processes the reply signals to determine relative bearing, slant range, and true bearing, calculate the submerged subsystem locations, and display the locations on a human machine interface. In some embodiments, the submerged subsystems may further include a compressed gas source and an enclosed flotation bag, and the surface subsystem may transmit a subsequent interrogation signal to actuate one or more submerged subsystems to inflate a flotation bag and enable recovery of the subsystem.

Abstract: Disclosed herein are systems and methods for ropeless fishing. The ropeless fishing system includes a surface subsystem installed on a vessel and at least one submerged subsystem submerged in a body of water. The surface subsystem includes acoustic transceiver and acoustic transducer units, which are configured to generate and omnidirectionally transmit an acoustic interrogation signal into the body of water surrounding the vessel and to directionally receive acoustic reply signals. The submerged subsystems include a compressed gas source and an enclosed flotation bag in fluid communication and an underwater acoustic actuator-transponder unit configured to receive the acoustic interrogation signal transmitted by the surface subsystem and to transmit an acoustic reply signal into the body of water. In addition, the submerged subsystem is further configured to control the flow of gas between the compressed gas source and the enclosed floatation bag to facilitate recovery of the submerged subsystem.

Abstract: Systems, methods and apparatus are provided for producing sand. Some embodiments include an agitator and dewatering screen. Some embodiments include a blending gate assembly configured to direct selected amounts of material to the agitator and to a crusher.

Abstract: The invention provides a method for maximising the production of recombinant proteins by generating the appropriate DNA, RNA, or protein sequence and/or genetic construct required for optimizing protein expression in the corresponding host organism.

Abstract: The present disclosure relates to combinations of a ?-lactam compound or a pharmaceutically acceptable salt thereof and probenecid or a pharmaceutically acceptable salt thereof. The present disclosure also relates to methods of treating or preventing a disease via administering to subjects in need thereof a ?-lactam compound or a pharmaceutically acceptable salt thereof and probenecid or a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure relates to combinations of valproic acid or a pharmaceutically acceptable salt thereof, a ?-lactam compound or a pharmaceutically acceptable salt thereof, and probenecid or a pharmaceutically acceptable salt thereof. The present disclosure also relates to methods of treating or preventing a disease using the combinations.

Abstract: An implantable fluid operated device includes a fluid control system to transfer fluid between a fluid reservoir and an inflatable member. The fluid control system includes at least one fluid control device including at least one pump and at least one valve, or at least one combination pump and valve device. A seal is provided in the at least one fluid control device. In a first mode, the seal provides a seal between a fluid passageway and a fluid chamber of the fluid control device, to close the fluid control device. In a second mode, the seal is disengaged to open the fluid control device and allow fluid to flow between the fluid passageway and the fluid chamber. A seal retention device maintains a position of the seal when the fluid control device is open and fluid is flowing through the fluid control device.

Abstract: The present disclosure relates to combinations of valproic acid or a pharmaceutically acceptable salt thereof, a ?-lactam compound or a pharmaceutically acceptable salt thereof, and probenecid or a pharmaceutically acceptable salt thereof. The present disclosure also relates to methods of treating or preventing a disease using the combinations.

Abstract: The present disclosure relates to combinations of a ?-lactam compound or a pharmaceutically acceptable salt thereof and probenecid or a pharmaceutically acceptable salt thereof. The present disclosure also relates to methods of treating or preventing a disease via administering to subjects in need thereof a ?-lactam compound or a pharmaceutically acceptable salt thereof and probenecid or a pharmaceutically acceptable salt thereof.

Abstract: An implantable medical device can include a housing including electronic devices within the housing, and a header attached to the housing. The header can include a first silicone portion configured to surround a first portion of internal electronics of the header, and a second silicone portion configured to surround a second portion of internal electronics of the header. The header can further include a splitline where the first silicone portion abuts the second silicone portion, wherein an outer edge of the first silicone portion and an outer edge of the second silicone portion are rounded at the splitline to prevent a sharp edge that may cause damage during assembly or insertion.

Abstract: An implantable medical device can include a housing including electronic devices within the housing, a header attached to the housing and including one or more bores, an antenna extending from the housing into the header, and an antenna clip configured to position and retain the antenna relative to the header.

Abstract: An implantable medical device can include a housing including electronic devices within the housing; a header attached to the housing and including one or more bores; a wire extending from the housing into the header and coupled to an electrical contact within the bore; and a wire clip configured to position and retain the wire relative to the header.

Abstract: The present disclosure relates to combinations of a ?-lactam compound or a pharmaceutically acceptable salt thereof and probenecid or a pharmaceutically acceptable salt thereof. The present disclosure also relates to methods of treating or preventing a disease via administering to subjects in need thereof a ?-lactam compound or a pharmaceutically acceptable salt thereof and probenecid or a pharmaceutically acceptable salt thereof.

Abstract: The present disclosure relates to bilayer tablets comprising a second layer comprising a ?-lactam compound or a pharmaceutically acceptable salt thereof; and a first layer comprising probenecid or a pharmaceutically acceptable salt thereof. The present disclosure also relates to methods of treating or preventing a disease using the bilayer tablets.

Abstract: The present disclosure relates to combinations of a ?-lactam compound or a pharmaceutically acceptable salt thereof and probenecid or a pharmaceutically acceptable salt thereof. The present disclosure also relates to methods of treating or preventing a disease via administering to subjects in need thereof a ?-lactam compound or a pharmaceutically acceptable salt thereof and probenecid or a pharmaceutically acceptable salt thereof.

Abstract: Disclosed herein are systems and methods for ropeless fishing. The ropeless fishing system includes a surface subsystem installed on a vessel and at least one submerged subsystem submerged in a body of water. The surface subsystem includes acoustic transceiver and acoustic transducer units, which are configured to generate and omnidirectionally transmit an acoustic interrogation signal into the body of water surrounding the vessel and to directionally receive acoustic reply signals. The submerged subsystems include a compressed gas source and an enclosed flotation bag in fluid communication and an underwater acoustic actuator-transponder unit configured to receive the acoustic interrogation signal transmitted by the surface subsystem and to transmit an acoustic reply signal into the body of water. In addition, the submerged subsystem is further configured to control the flow of gas between the compressed gas source and the enclosed floatation bag to facilitate recovery of the submerged subsystem.

Abstract: The present disclosure relates to bilayer tablets comprising a second layer comprising a ?-lactam compound or a pharmaceutically acceptable salt thereof; and a first layer comprising probenecid or a pharmaceutically acceptable salt thereof. The present disclosure also relates to methods of treating or preventing a disease using the bilayer tablets.

Abstract: The present disclosure relates to combinations of valproic acid or a pharmaceutically acceptable salt thereof, a ?-lactam compound or a pharmaceutically acceptable salt thereof, and probenecid or a pharmaceutically acceptable salt thereof. The present disclosure also relates to methods of treating or preventing a disease using the combinations.